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Keywords: transcription
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Journal Articles
Journal: Development
Development (2022) 149 (11): dev200153.
Published: 6 June 2022
...Cai-Li Bi; Qian Cheng; Ling-Yue Yan; Hong-Yan Wu; Qiang Wang; Ping Wang; Lin Cheng; Rui Wang; Lin Yang; Jian Li; Feng Tie; Hao Xie; Ming Fang ABSTRACT The evolutionarily conserved C-terminal binding protein (CtBP) has been well characterized as a transcriptional co-repressor. Herein, we report...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200074.
Published: 9 February 2022
... of Biologists Ltd 2022 We previously identified an essential function of TBP-associated factor 4b (TAF4b) in the establishment of the ovarian reserve in the embryonic mouse ovary ( Grive et al., 2014 , 2016 ). TAF4b is a germ cell-enriched subunit of the transcription factor TFIID complex, which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199991.
Published: 17 December 2021
... alleles are transcriptionally active. The median fluorescence intensity of twi TSs along the DV axis was also uniform, indicating a similar rate of Pol II loading onto all twi loci throughout the mesodermal domain ( Fig. 2 D). The uniform activation of twi transcription is also corroborated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199744.
Published: 7 September 2021
... in transcription-dependent condensates . Science 361 , 412 - 415 . 10.1126/science.aar4199 Cisse , I. I. , Izeddin , I. , Causse , S. Z. , Boudarene , L. , Senecal , A. , Muresan , L. , Dugast-Darzacq , C. , Hajj , B. , Dahan , M. and Darzacq , X. ( 2013...
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199477.
Published: 6 September 2021
...Margherita Peron; Alberto Dinarello; Giacomo Meneghetti; Laura Martorano; Riccardo M. Betto; Nicola Facchinello; Annachiara Tesoriere; Natascia Tiso; Graziano Martello; Francesco Argenton ABSTRACT The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... that Pou2f2 functions by binding a POU-binding motif located 55 bp upstream of the transcription start site of Nrl. As Pou2f1 and Pou2f2 are co-expressed in RPCs, we posit that Pou2f1 induces Pou2f2 expression prior to cell cycle exit, which may lead to sufficient levels of Pou2f2 expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev190330.
Published: 24 July 2020
...Brett R. Lancaster; James D. McGhee ABSTRACT We define a quantitative relationship between the affinity with which the intestine-specific GATA factor ELT-2 binds to cis -acting regulatory motifs and the resulting transcription of asp-1 , a target gene representative of genes involved...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190231.
Published: 11 June 2020
... silencing complex (RISC). The mechanism for growth inhibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 controls cell and tissue growth by functioning as a direct transcriptional repressor of the master regulator of growth, Myc. AGO1 depletion in wing imaginal discs drives...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev179069.
Published: 27 April 2020
... transcriptional co-activators Yorkie, YAP and TAZ is far more dynamic than previously appreciated, and YAP and TAZ are also regulated by liquid-liquid phase separation. Here, we review our current understanding of Yorkie, YAP and TAZ regulation, with a focus on recent microscopy-based studies...
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
... ( Fig. 3 ), it appears that gene activation is likely to be the major mode of differential gene expression during Drosophila spermatogenesis. On the other hand, genes with stable levels of transcripts ( Fig. S7 ) could still be regulated post-transcriptionally, which is extensively used...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev180018.
Published: 22 January 2020
... with CHR2 ( Wang et al., 2018 ). CHR2 is an ATPase in the SWI2/SNF2 nucleosome remodeling complex, and affects miRNA expression not only through transcription, but also via an inhibitory role in remodeling primary(pri)-miRNAs to prevent their processing ( Wang et al., 2018 ). The mechanistic crossover...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev182568.
Published: 20 December 2019
... and cellular pathways that regulate prothoracic gland function are relatively well studied, the transcriptional regulators that orchestrate the activity of this tissue remain less characterized. Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic gland function. Indeed, restoring kdm5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev182766.
Published: 25 September 2019
... Genome organization Phase separation Transcription The cell nucleus is a crowded environment. This is easily appreciated by considering that the almost 2 m long DNA polymer that comprises the human genome is packaged into a ∼6-10 µm diameter cell nucleus along with all the biological...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev180190.
Published: 24 June 2019
... patterns ( Fig. 1 , Fig. S1 and Table S1 ) supports our conclusions that these markers are associated with the pluripotent epiblast. It might be that changes in the transcription of these genes happens abruptly at ∼E8.25 and that there is a difficulty in staging the embryos. The transition from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (10): dev173112.
Published: 22 May 2019
...Elena Sena; Nathalie Rocques; Caroline Borday; Harem Sabr Muhamad Amin; Karine Parain; David Sitbon; Albert Chesneau; Béatrice C. Durand ABSTRACT A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on the cell and developmental...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (8): dev162628.
Published: 23 April 2019
...Berta Terré; Michael Lewis; Gabriel Gil-Gómez; Zhiyuan Han; Hao Lu; Mònica Aguilera; Neus Prats; Sudipto Roy; Haotian Zhao; Travis H. Stracker ABSTRACT GEMC1 and MCIDAS are geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including Foxj 1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev170498.
Published: 1 April 2019
... early mesoderm cell fate decisions. We found that Cdx2 occupies a number of transcription factor loci during embryogenesis, including key regulators of both cardiac and blood development, and that Cdx function is required for normal expression of the cardiogenic transcription factors Nkx2-5 and Tbx5...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2018) 145 (24): dev158352.
Published: 10 December 2018
... of the meristem marker SHOOT MERISTEMLESS ( STM ) in the leaf axil. Here, we show that modules of interacting transcriptional regulators control STM expression and AM initiation. Two redundant AP2-type transcription factors, DORNRÖSCHEN ( DRN ) and DORNRÖSCHEN-LIKE ( DRNL ), control AM initiation by regulating...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev164384.
Published: 22 October 2018
...Mathieu Tremblay; Oraly Sanchez-Ferras; Maxime Bouchard ABSTRACT The GATA family of transcription factors is of crucial importance during embryonic development, playing complex and widespread roles in cell fate decisions and tissue morphogenesis. GATA proteins are essential for the development...
Journal Articles
Journal: Development
Development (2018) 145 (6): dev137729.
Published: 22 March 2018
... transcriptional and chromatin states; and loop domains, which depend on the occupancy of architectural proteins such as CTCF and cohesin. See also Box 2. The full spectrum of genes that can be transcriptionally regulated by CTCF also seems to depend on the cell type being analyzed. For example, inactivation...