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Keywords: transcription
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Journal Articles
Journal: Development
Development (2023) 150 (21): dev202024.
Published: 6 November 2023
...Michael F. Rogers; Owen J. Marshall; Julie Secombe ABSTRACT Histone-modifying proteins play important roles in the precise regulation of the transcriptional programs that coordinate development. KDM5 family proteins interact with chromatin through demethylation of H3K4me3 as well as demethylase...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (15): dev201548.
Published: 2 August 2023
...Min Tang; Isabel Regadas; Sergey Belikov; Olga Shilkova; Lei Xu; Erik Wernersson; Xuewen Liu; Hongmei Wu; Magda Bienko; Mattias Mannervik ABSTRACT The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex, and its canonical function is in transcriptional repression...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (16): dev200398.
Published: 30 August 2022
...Laura J. Harrison; Daniel Bose ABSTRACT Enhancers confer precise spatiotemporal patterns of gene expression in response to developmental and environmental stimuli. Over the last decade, the transcription of enhancer RNAs (eRNAs) – nascent RNAs transcribed from active enhancers – has emerged...
Journal Articles
Journal: Development
Development (2022) 149 (11): dev200153.
Published: 6 June 2022
...Cai-Li Bi; Qian Cheng; Ling-Yue Yan; Hong-Yan Wu; Qiang Wang; Ping Wang; Lin Cheng; Rui Wang; Lin Yang; Jian Li; Feng Tie; Hao Xie; Ming Fang ABSTRACT The evolutionarily conserved C-terminal binding protein (CtBP) has been well characterized as a transcriptional co-repressor. Herein, we report...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200074.
Published: 9 February 2022
... mouse oocyte transcription network, including reproduction and chromatin genes, through unexpected promoter localization of TAF4b at Sp/Klf- and NFY-binding sites. Transcription Oogenesis Oocytes Meiosis I TFIID TAF4b POI Fetal oocyte attrition Mouse National Institute of Child...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199991.
Published: 17 December 2021
.... First, activation of target-gene expression expands over time from the ventral-most region of high nuclear Dorsal to lateral regions, where the levels are lower, as a result of a Dorsal-dependent activation probability of transcription sites. Thus, sites that are activated earlier will exhibit more mRNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199744.
Published: 7 September 2021
... underlying gene regulation. This Review covers core technologies, concepts, recent advances and applications of in vivo single-molecule tracking. Fluorescence Gene regulation Light-sheet Single-molecule microscopy Single-molecule tracking Transcription Children's Hospital...
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... represses the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina. Cell fate Mouse Photoreceptors Retina Temporal patterning Transcription The generation of neuronal diversity is crucial to building a functional nervous system. Classical studies have shown...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190231.
Published: 11 June 2020
... silencing complex (RISC). The mechanism for growth inhibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 controls cell and tissue growth by functioning as a direct transcriptional repressor of the master regulator of growth, Myc. AGO1 depletion in wing imaginal discs drives...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev179069.
Published: 27 April 2020
.... Additionally, there is emerging evidence that the rate of shuttling, independent of the total nuclear pool, may be important for the transcriptional function of YAP ( Franklin et al., 2019 preprint), and that it is possible for Yki/YAP/TAZ to localise to the nucleus but be transcriptionally inactive ( Parker...
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
..., which is different from somatic cells. Together, our single cyst-resolution, genome-wide transcriptional profile analyses provide an unprecedented resource to understand many questions in both germ cell biology and stem cell biology fields. * Present address: Geometrix Tech, 433 Guo Shoujing Road...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev180018.
Published: 22 January 2020
... describes roles for the RNA processing factor Ars2 in diverse aspects of mammalian neurogenesis, and reveals its broad role as a chromatin factor in this context. Ars2 SRRT SOX2 Neurogenesis Mouse Transcription ChIP-seq Proper regulation of neural stem cell (NSC) lineage progression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev182568.
Published: 20 December 2019
... and cellular pathways that regulate prothoracic gland function are relatively well studied, the transcriptional regulators that orchestrate the activity of this tissue remain less characterized. Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic gland function. Indeed, restoring kdm5...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev182766.
Published: 25 September 2019
... in regulating gene expression at a workshop organized by The Company of Biologists titled ‘Chromatin-based regulation of development’. Chromatin topology Condensates Gene regulation Genome organization Phase separation Transcription The cell nucleus is a crowded environment. This is easily...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev180190.
Published: 24 June 2019
... expression patterns ( Fig. 1 , Fig. S1 and Table S1 ) supports our conclusions that these markers are associated with the pluripotent epiblast. It might be that changes in the transcription of these genes happens abruptly at ∼E8.25 and that there is a difficulty in staging the embryos. The transition from...
Includes: Supplementary data