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Keywords: stem cells
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Journal Articles
Journal: Development
Development (2022) 149 (22): dev191957.
Published: 28 November 2022
... element activities that, if left uncontrolled, create an insurmountable barrier to tissue repair. Transposable elements Regenerative biology Inflammation Proliferation Stem cells Empire State Stem Cell Fund C30293GG National Institutes of Health http://dx.doi.org/10.13039...
Journal Articles
Journal: Development
Development (2022) 149 (21): dev200899.
Published: 9 November 2022
... the RAM of mto2-2 is represented solely by the TD, the known factors of RAM maintenance and auxin signaling are expressed in the mutant. Mathematical modeling predicts that the stem cell niche depends on Thr metabolism and that, when disturbed, the normal continuum of cell states becomes aborted...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201004.
Published: 31 October 2022
... organoids in vitro from embryonic, fetal and adult cells, as well as pluripotent stem cells. We discuss how these systems have been used to learn new aspects of pancreas development, regeneration and disease, as well as their limitations and potential for future discoveries. * Author for correspondence...
Journal Articles
Journal: Development
Development (2022) 149 (20): dev201070.
Published: 11 October 2022
...Fiona M. Bain; James L. C. Che; Maria Jassinskaja; David G. Kent ABSTRACT Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC...
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200831.
Published: 30 August 2022
... the underlying gene regulatory networks and signalling pathways, have been for the most part characterised in animal models. In this Review, we describe how placode development can be recapitulated by the differentiation of human pluripotent stem cells towards placode progenitors and their derivatives...
Journal Articles
Journal: Development
Development (2022) 149 (20): dev199914.
Published: 6 July 2022
..., inherited neurometabolic disorder that presents with bilateral brain lesions caused by defects in the mitochondrial respiratory chain and associated nuclear-encoded proteins. We generated human induced pluripotent stem cells (iPSCs) from three LS patient-derived fibroblast lines. Using whole-exome...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (13): dev200797.
Published: 1 July 2022
... Embryogenesis Evolution Stem cells Regeneration Animal-microbe Symbiosis Alexander von Humboldt-Stiftung Deutsche Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 261376515 Collaborative Research Centre 1182 Canadian Institute for Advanced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199903.
Published: 3 May 2022
... the ability of cells outside of the adaptive immune system to respond to recurring infections through the lens of evolution and cellular memory. With this in mind, we then discuss the bidirectional crosstalk between the immune cells and stem cells and present examples where these interactions regulate tissue...
Journal Articles
Journal: Development
Development (2022) 149 (7): dev197947.
Published: 31 March 2022
... to constrain cells and tissues. Recent work using micropatterning has demonstrated that a combination of geometric confinement and small molecule induction can steer the development of human stem cell sheets from 2D to 3D neural tubes ( Karzbrun et al., 2018 , 2021 ; Warmflash et al., 2014 ) ( Fig. 6 B...
Journal Articles
Journal: Development
Development (2022) 149 (7): dev200115.
Published: 31 March 2022
...Viju Vijayan Pillai; Tiffany G. Kei; Shailesh Gurung; Moubani Das; Luiz G. B. Siqueira; Soon Hon Cheong; Peter J. Hansen; Vimal Selvaraj ABSTRACT Exponential proliferation of trophoblast stem cells (TSC) is crucial in Ruminantia to maximize numerical access to caruncles, the restricted uterine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev192914.
Published: 15 December 2021
... stem cells that are easy to access, track, manipulate and scale. Here, we explain how unlocking distinct levels of embryo-like architecture through controlled modulations of the cellular environment enables the identification of minimal sets of mechanical and biochemical inputs necessary to pattern...
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199683.
Published: 9 November 2021
... stem cells of small intestinal (SI) crypts. To examine NF–κB functions in SI epithelial self-renewal, mice or SI crypt organoids (‘mini-guts’) with ubiquitously suppressed NF-κB activity were used. We show that NF-κB activity is dispensable for maintaining SI epithelial proliferation, but is essential...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199909.
Published: 28 October 2021
...: from fertilisation to blastocyst. Furthermore, we highlight current advances in elucidating the significance of specific microtubule arrays in in vitro culture systems of pluripotent stem cells and how the microtubule cytoskeleton serves as a highway for the precise intracellular movement of organelles...
Journal Articles
Journal: Development
Development (2021) 148 (15): dev186387.
Published: 3 August 2021
...-organisation Stem cells University of Edinburgh http://dx.doi.org/10.13039/501100000848 Wellcome Trust http://dx.doi.org/10.13039/100010269 IS3-R1.16 19/20 Technology development is motivated by the need to overcome specific problems. In vivo , the native environment...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev186106.
Published: 9 March 2021
...Meghan Ferguson; Kristina Petkau; Minjeong Shin; Anthony Galenza; David Fast; Edan Foley ABSTRACT Microbial factors influence homeostatic and oncogenic growth in the intestinal epithelium. However, we know little about immediate effects of commensal bacteria on stem cell division programs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev189753.
Published: 9 March 2021
...Liang Zhang; Daniel DeGennaro; Guangzhong Lin; Jijie Chai; Elena D. Shpak ABSTRACT The shoot apical meristem (SAM) is a reservoir of stem cells that gives rise to all post-embryonic above-ground plant organs. The size of the SAM remains stable over time owing to a precise balance of stem cell...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev165084.
Published: 8 February 2021
...Noelia Urbán; Tom H. Cheung ABSTRACT Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for life-long tissue homeostasis and regenerative capacity. Quiescence has...
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193458.
Published: 18 January 2021
.... Elucidating the cellular players and their regulation mechanisms provides fundamental information to deepen understanding about the responses and contributions of lung stem cells. This Review focuses on advances in our understanding of mammalian alveolar epithelial stem cell subpopulations and discusses...
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (24): dev189746.
Published: 24 December 2020
... series of events. However, the human retina shows many differences from that of other organisms and the investigation of human eye development now benefits from stem cell-derived organoids. Retinal differentiation methods have progressed from simple 2D adherent cultures to self-organising micro...
Journal Articles
Journal: Development
Development (2020) 147 (22): dev194100.
Published: 15 November 2020
...Pooja Flora; Elena Ezhkova ABSTRACT Cell divisions and cell-fate decisions require stringent regulation for proper tissue development and homeostasis. The mammalian epidermis is a highly organized tissue structure that is sustained by epidermal stem cells (ESCs) that balance self-renewal and cell...