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Keywords: splotch
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Journal Articles
Journal: Development
Development (2004) 131 (14): 3367–3379.
Published: 15 July 2004
... pathway was significantly reduced in Sp 2H /Sp 2H embryos. To resolve current controversy over the cell autonomy of the splotch cardiac neural crest defect, we performed reciprocal grafts of premigratory neural crest between wild type and splotch embryos. Sp 2H /Sp 2H cells migrated normally...
Journal Articles
Journal: Development
Development (2002) 129 (2): 527–538.
Published: 15 January 2002
... of cranial neural crest migrate from the hindbrain into the outflow tract of the heart where they contribute to the septum that divides the pulmonary and aortic channels. In Splotch mutant mice, which lack a functional Pax3 gene, migration of cardiac neural crest is deficient and aorticopulmonary septation...