..., the expanded amnion and serosa anlage correlates with a broader domain of Dpp signaling as compared with the D. melanogaster embryo. Evidence is presented that this expanded signaling is due to altered expression of the sog gene. The loss of dpp ( Fig. 5A ), tkv ( Fig. 5C ), Doc1 ( Fig. 4E ), Doc2...

...Yasuko Akiyama-Oda; Hiroki Oda The mechanism by which Decapentaplegic (Dpp) and its antagonist Short gastrulation (Sog) specify the dorsoventral pattern in Drosophila embryos has been proposed to have a common origin with the mechanism that organizes the body axis in the vertebrate embryo. However...

... inhibitor Short gastrulation (Sog). In this study, we provide evidence that Tlr also contributes to Sog processing. Tlr cleaves Sog in vitro in a Bmp-dependent manner at the same three major sites as does Tld. However, Tlr shows different site selection preferences and cleaves Sog with slower kinetics...

...Helena Araujo; Erika Negreiros; Ethan Bier Morphogenesis of the Drosophila wing depends on a series of cell-cell and cell-extracellular matrix interactions. During pupal wing development, two secreted proteins, encoded by the short gastrulation ( sog ) and decapentaplegic ( dpp ) genes, vie...

... to reductions in Dpp and Gbb signaling. The hypomorphic gbb 4 mutation shows complete loss of the cross veins (CVs), but only slight loss of the ends of the LVs ( Khalsa et al., 1998 ). Sog encodes a Chordin-like molecule that inhibits BMP-like signaling; both Sog and Chordin are thought to bind...

...H. Araujo; E. Bier ABSTRACT The short gastrulation (sog) and decapentaplegic (dpp ) genes function antagonistically in the early Drosophila zygote to pattern the dorsoventral (DV) axis of the embryo. This interplay between sog and dpp determines the extent of the neuroectoderm and subdivides...

... inhibitor, Short gastrulation (Sog) and a newly identified transcriptional repressor, Brinker (Brk), which are expressed in neurogenic regions that abut the dorsal ectoderm. Here we examine the expression of a number of Dpp target genes in transgenic embryos that contain ectopic stripes of Dpp, Sog and Brk...

... ( sog ) in ventrolateral regions of the embryo abutting the dpp domain. Here, both brk and sog antagonize the antineurogenic activity of Dpp so that only in brk sog double mutants is the neuroectoderm completely deleted. * Authors for correspondence (e-mail: chris.rushlow@nyu.edu ; sroth...