...Stephanie Hilz; Andrew J. Modzelewski; Paula E. Cohen; Andrew Grimson MicroRNAs and siRNAs, both of which are AGO-bound small RNAs, are essential for mammalian spermatogenesis. Although their precise germline roles remain largely uncharacterized, recent discoveries suggest that they function...

...@wi.mit.edu ; laie@mskcc.org ) Competing interests statement The authors declare no competing financial interests. © 2011. microRNA piRNA siRNA Central to understanding the process of development is knowledge of how gene activity can be controlled precisely and robustly...

...Nayoung Suh; Robert Blelloch Small non-coding RNAs, including microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs) and Piwi-interacting RNAs (piRNAs), play essential roles in mammalian development. The function and timing of expression of these three classes of small RNAs differ...

... of trans-acting (ta) siRNAs, but is required for the production and/or stability of tasiR-ARF , a ta-siRNA that targets both ETT/ARF3 and ARF4. tasiR-ARF is absent in zip-2 , and overexpression of a tasiR-ARF -insensitive form of ETT mimics the zip phenotype. We conclude that the precocious phenotype...