.... (A) Mechanism of estrogen signaling and action in zebrafish sex differentiation. The ovarian aromatase ( cyp19a1a ) plays a crucial role via nuclear estrogen receptors (nERs) in driving ovarian differentiation by suppressing the expression of dmrt1 , which by default directs all individuals towards males. (B...

... Oogenesis p53 Zebrafish Translational control ER stress Unfolded protein response Apoptosis Sex differentiation In contrast to spermatogenesis, oogenesis is associated with increasing cell volume and accumulating maternal molecules such as RNAs and proteins, which are essential for oogenesis...

... by The Company of Biologists Ltd Male germ cells Nodal/activin signaling Nanos2 Sex differentiation Nodal conditional knockout Smad4 conditional knockout Mouse Testicular differentiation in the mouse is triggered by transient expression of the Sry gene in pre-Sertoli...

... ) Competing interests statement The authors declare no competing financial interests. 25 4 2012 © 2012. AMH Gonad Medaka Germ cells Sex differentiation Sex reversal Anti-Müllerian hormone (AMH) is a highly conserved member of the TGFβ superfamily of proteins...

... for correspondence ( aykanai@mail.ecc.u-tokyo.ac.jp ) 10 11 2009 © 2010. 2010 Sry Sox9 Fgf9 Sertoli cell Sex differentiation Gonad Anteroposterior axis Mouse In mammals, Sry (sex determining region of Chr Y) is cell-autonomously essential in the supporting cells...

... Wnt4 Sertoli cells Sex differentiation Mouse Surprisingly, in genital ridges explanted at 18 to 21 ts, a stage at which all explants display ovarian development at later stages, SOX9-positive cells were detectable after 6 hours in culture and had increased in number by 9 hours ( Fig. 3A...

... their differentiation. Fig. 7. Proposed mechanism of the role of Dax1 in sex differentiation. Expression of Dax1 (red) in relation to dividing cells (BrdU, green) at 12.5 dpc. Broken line reflects the coelomic surface. TC, testis cords. Arrow indicates Dax1-positive cells below the coelomic surface. Dax1...

... since this gene has a conserved Ad4-binding site within the promoter, which is recognized by Ad4BP expressed in the fetal testes. * Author for correspondence 23 06 1994 © 1994 by Company of Biologists 1994 Ad4BP steroidogenic cell P-450 sex differentiation Müllerian...

... birth, concurrent with the onset of spermatogenesis. * Author for correspondence 22 09 1993 © 1994 by Company of Biologists 1994 anti-müllerian hormone activin TGF-β receptor sex differentiation testis ovary The cloning of receptors for the peptide growth factors...

... ( Prokop and Technau, 1991 ). The majority of the embryonic neuroblasts in thoracic segments but only a few abdominal neuroblasts engage in postembryonic neurogenesis ( Booker and Truman, 1987 ; Truman and Bate, 1988 ). neural development Drosophila sex differentiation © 1992 by Company...

... that in this marsupial species gonadal differentiation may be initiated in utero . © 1990 by Company of Biologists 1990 marsupials sex differentiation gonads testis development In eutherian mammals the sexual differentiation of the gonads occurs prenatally and the newborn are anatomi cally...