... conferred by segment polarity genes and dorsoventral patterning genes. We have studied mechanisms leading to the fate specification of a set of late delaminating neuroblasts, NB 6-4 and NB 7-3, both of which arise from the engrailed ( en ) expression domain, with NB 6-4 delaminating first. In contrast...

... by Company of Biologists 2000 Armadillo Dorsal closure Segment polarity Puckered Wingless JNK Wnt β-catenin Drosophila Proper patterning of multicellular organisms depends on stringent regulation of cell-cell signaling. Members of the Wnt/Wingless (Wg) family of secreted...

... the whole denticle pattern. Author for correspondence (e-mail: JP.Vincent@nimr.mrc.ac.uk ) 24 11 1999 05 10 1999 © 1999 by Company of Biologists 1999 Drosophila Denticle pattern Segment polarity Hedgehog Wingless Egfr Notch The situation with Hedgehog is clearer...

... of sequences from wingless segment polarity gene in Drosophila: the spatial distribution of the transcript in embryos . EMBO J . 6 , 1765 – 1774 . 10.1002/j.1460-2075.1987.tb02429.x Baker , N. ( 1988 ). Localisation of transcripts from the wingless gene in whole Drosophila embryos...

... 1997 by Company of Biologists 1997 hedgehog engrailed pattern formation segment polarity gradient compartment Drosophila The epidermis of the embryonic segments and imaginal discs of Drosophila is organized into lineage compartments defined by expression of selector genes...

... 1997 © 1997 by Company of Biologists 1997 optomotor-blind hedgehog pattern formation segment polarity Drosophila The epidermis of each segment in Drosophila is subdivided into anterior and posterior lineage compartments defined by expression of the engrailed ( en...

... and that they account for the main difference in shape between abdominal and thoracic denticle belts. * Author for correspondence (e-mail: mb2@mrc-lmb.cam.ac.uk ) 18 06 1997 © 1997 by Company of Biologists 1997 EGFR signalling Wingless segment polarity larval cuticle faint little ball...

.... ( 1988 ). Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila . Dev. Biol . 125 , 96 – 108 . 10.1016/0012-1606(88)90062-0 Baylies , M. K. , Martinez Arias , A. and Bate , M. ( 1995 ). wingless is required for the formation of a subset...

... a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo . Genes Dev . 8 , 2588 – 2601 . 10.1101/gad.8.21.2588 Baker , N. E. ( 1987 ). Molecular cloning of sequences from wingless a segment polarity gene in Drosophila...

... as a means of altering cell fates and generating dominant phenotypes . Development 118 , 401 – 415 . 10.1242/dev.118.2.401 Capdevila , J. , M. P. Estrada , E. Sánchez-Herrero and I. Guerrero ( 1994 ) The Drosophila segment polarity gene patched interacts...

...Armen S. Manoukian; Kenneth B. Yoffe; Elizabeth L. Wilder; Norbert Perrimon ABSTRACT The Drosophila segment polarity gene wingless (wg) is required in the regulation of engrailed (en) expression and the determination of cell fates in neighboring cells. This paracrine wg activity also regulates...

.... 18 wheeler transcripts accumulate in embryos in a pattern reminiscent of segment polarity genes. Mutations in 18w cause death during larval development and early adulthood. Escaping mutant adults often display leg, antenna, and wing deformities, presumably resulting from improper eversion of imaginal...

...Marcel van de Heuvel; John Klingensmith; Norbert Perrimon; Roel Nusse ABSTRACT By a complex and little understood mechanism, segment polarity genes control patterning in each segment of the Drosophila embryo. During this process, cell to cell communication plays a pivotal role and is under direct...

...Naren R. Ramakrishna; Anthony M. C. Brown ABSTRACT The segment polarity gene wingless is the Drosophila ortholog of mouse Wni-1, a proto-oncogene capable of causing transformation of mammary epithelial cells. These two genes presently represent the best studied members of the Wnt gene family...

...Amy Bejsovec; Eric Wieschaus ABSTRACT Each segment of a Drosophila larva shows a precisely organized pattern of cuticular structures, indicating diverse cellular identities in the underlying epidermis. Mutations in the segment polarity genes alter the cuticle pattern secreted by the epidermal cells...

... of transcripts encoded by the pair-rule genes fushi tarazu ( ftz ) and even-skipped ( eve ) and later by stripes encoded by the segment polarity genes engrailed ( en ) and wingless . Here, we show that the runt gene ( run ) is required to generate asymmetries within these parasegmental domains. Using a heat...

... development by the engrailed gene of Drosophila Nature 255 , 614 – 617 10.1038/255614a0 Ormk , T. V. , Slusarski , D. C. , Kroll , K. L. and Ho\ mgrffl , R. A. ( 1990 ) Clomng and charactenzat10n of the segment polarity gene cub1tus mterruptus Dominant of Drosophila...

... wingless segment polarity Drosophila segmentation pattern formation The larval epidermis of insects secretes a highly patterned array of cuticular structures, revealing an underlying pattern of differences in the epidermal cells within each segment ( Wigglesworth, 1940 ; 1973 ). For example...

...Roger G. Phillips; Ian J. H. Roberts; Philip W. Ingham; J. Robert S. Whittle We demonstrate the role of the segment polarity gene patched (ptc) in patterning in the cuticle of the adult fly. Genetic mosaics of a lethal allele of patched show that the contribution of patched varies in a position...

...A. Martinez Arias; N. E. Baker; P. W. Ingham Segment polarity genes are expressed and required in restricted domains within each metameric unit of the Drosophila embryo. We have used the expression of two segment polarity genes engrailed (en) and wingless (wg) to monitor the effects of segment...