... Review highlights the novel insights into stem cell regulation, new technologies aiding in discovery and exciting breakthroughs in the field of regenerative medicine that emerged from the meeting. From the presentations at this meeting it is evident that the field of stem cell biology...

... Regulation Chimera Scientific work to date hints at possible moral concerns about the ‘creation of life’ and/or the acquisition of human qualities in research involving human organoids. Accordingly, it is important to consider potential ethical issues that may become relevant depending...

...) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree...

... the specification of the pronephric territory and define its size. This seems to occur, at least in part, through positive regulation of Bmp signalling. Subsequently, Irx genes are required for proper formation of the intermediate tubule. Finally, we find that retinoic acid signalling activates both Irx1 and Irx3...

..., we describe at least two modes of regulating the expression of Ath5 during retinal development. We have found that a proximal cis-regulatory region of the Xenopus Ath5 gene ( Xath5 ) is highly conserved across vertebrate species and is sufficient to drive retinal-specific reporter gene expression...

... it is displaced from its normal position to the C terminus of Engrailed 2, leading to a constitutive blockage of Engrailed 2 intercellular transfer. This indicates that intercellular transfer of Engrailed 2 is a highly regulated process. *Author for correspondence (e-mail: joliot@biologie.ens.fr ) 30 4...

...Hong Zhang; Scott W. Emmons ABSTRACT We describe the properties of a new gene, sop-3 , that is required for the regulated expression of a C. elegans Hox gene, egl-5 , in a postembryonic neuroectodermal cell lineage. Regulated expression of egl-5 in this cell lineage is necessary for development...

...John F. Rawls; Stephen L. Johnson ABSTRACT Fin regeneration in adult zebrafish is accompanied by reestablishment of the pigment stripes. To understand the mechanisms underlying fin stripe regeneration and regulation of normal melanocyte stripe morphology, we investigated the origins of melanocytes...

.... In the mesenchyme Dlx2 is expressed proximally, whereas in oral epithelium it is expressed distally. Dlx2 has been shown to be involved in the patterning of the murine dentition, since loss of function of Dlx1 and Dlx2 results in early failure of development of upper molar teeth. We have investigated the regulation...

... ‡ These authors contributed equally to this work 15 09 1999 09 11 1999 © 1999 by Company of Biologists 1999 Hindbrain Mouse Rhombomere 4 Motor Neurons Hoxb1 GATA2 GATA3 Regulation GATA3 is a member of the family of transcription factors that have recently emerged...

..., the complex spatial pattern of CyIIa expression is completely reproduced by a compact upstream regulatory element <450 bp in length. We found no evidence anywhere in the 4.4 kb sequence examined for negative regulators required to repress ectopic expression. The specific site that mediates CyIIa expression...

... crest and phenocopies a retinoic acid -induced phenotype . Development 122 , 735 – 746 . 10.1242/dev.122.3.735 Ang , S.-L. , Conlon , R. A. , Jin , O. and Rossant , J. ( 1994 ). Positive and negative signals from mesoderm regulate the expression of mouse Otx2...

...George N. Serbedzija; Jau-Nian Chen; Mark C. Fishman ABSTRACT In many vertebrates, removal of early embryonic heart precursors can be repaired, leaving the heart and embryo without visible deficit. One possibility is that this ‘regulation’ involves a cell fate switch whereby cells, perhaps...

... the reconstituted Hensen’s node and, therefore, acts like a Nieuwkoop Center. These findings increase our understanding of the mechanism of notochord reconstitution, provide new information and a novel model system for studying the induction of the organizer and reveal the potential of the epiblast to regulate its...

... unilaterally by micro-surgery. Of the embryos that survived, about 35% exhibited regulative regeneration, wherein the missing hemi-rhombomere was reconstituted to normal size and morphology through compensatory proliferation and migration from adjacent tissue. The capacity for regener-ation depended...

... bordering the ablated region demonstrate that cells at the same axial level, in the lateral and ventral neural tube, regulate to reconstitute a population of neural crest cells. These cells emigrate from the neural tube, migrate along normal pathways according to their axial level of origin and appear...

... for the normal function of a microtubule array. * Author for correspondence 17 09 1992 © 1993 by Company of Biologists 1993 tubulin isotype regulation meiosis mitosis spindles Drosophila Morphogenesis requires the microtubule cytoskeleton to undergo continual...

... that requires the activity of other segment polarity genes including patched ( ptc ) and hedgehog ( hh ). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show...

... that the accessory axons are thought to play in respect of the later developing fibres of the main bulb. * Author for correspondence 14 05 1990 © 1990 by Company of Biologists 1990 neuronal differentiation axonogenesis dendrogenesis olfactory system Thy-1 glycoprotein regulation...

..., but MBP Polypeptide was not detectable even under conditions where MBP RNA was induced. The results with this clonal model suggest that cAMP plays a pivotal role in regulation of growth and gene expression during Schwann cell differentiation. 27 03 1989 © 1989 by Company of Biologists 1989...