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Keywords: regulation
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Journal Articles
Journal: Development
Development (2017) 144 (17): 3007–3011.
Published: 1 September 2017
... Review highlights the novel insights into stem cell regulation, new technologies aiding in discovery and exciting breakthroughs in the field of regenerative medicine that emerged from the meeting. While studies on the developing embryo are commonly conducted by stem cell researchers with a view...
Journal Articles
Journal: Development
Development (2017) 144 (6): 942–945.
Published: 15 March 2017
... Regulation Chimera Considerable research activity is currently focused on a variety of human organoids and similar self-organizing structures such as gastruloids (hereafter collectively referred to as ʻorganoids', unless otherwise specified). Such research has already led to an enhanced...
Journal Articles
Journal: Development
Development (2016) 143 (11): 1838–1847.
Published: 1 June 2016
...) was shown to be a transcriptional product in thousands of human and mouse genes and in hundreds of cases constituted the dominant RNA isoform. Subsequent studies revealed that the expression of circRNAs is developmentally regulated, tissue and cell-type specific, and shared across the eukaryotic tree...
Journal Articles
Journal: Development
Development (2008) 135 (19): 3197–3207.
Published: 1 October 2008
... the specification of the pronephric territory and define its size. This seems to occur, at least in part, through positive regulation of Bmp signalling. Subsequently, Irx genes are required for proper formation of the intermediate tubule. Finally, we find that retinoic acid signalling activates both Irx1 and Irx3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 829–839.
Published: 15 February 2005
..., we describe at least two modes of regulating the expression of Ath5 during retinal development. We have found that a proximal cis-regulatory region of the Xenopus Ath5 gene ( Xath5 ) is highly conserved across vertebrate species and is sufficient to drive retinal-specific reporter gene expression...
Journal Articles
Journal: Development
Development (2002) 129 (15): 3545–3553.
Published: 1 August 2002
... it is displaced from its normal position to the C terminus of Engrailed 2, leading to a constitutive blockage of Engrailed 2 intercellular transfer. This indicates that intercellular transfer of Engrailed 2 is a highly regulated process. References Allende, J. E. and Allende, C. C. ( 1995 ). Protein kinase...
Journal Articles
Journal: Development
Development (2001) 128 (5): 767–777.
Published: 1 March 2001
...Hong Zhang; Scott W. Emmons ABSTRACT We describe the properties of a new gene, sop-3 , that is required for the regulated expression of a C. elegans Hox gene, egl-5 , in a postembryonic neuroectodermal cell lineage. Regulated expression of egl-5 in this cell lineage is necessary for development...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (2): 217–224.
Published: 15 January 2000
.... In the mesenchyme Dlx2 is expressed proximally, whereas in oral epithelium it is expressed distally. Dlx2 has been shown to be involved in the patterning of the murine dentition, since loss of function of Dlx1 and Dlx2 results in early failure of development of upper molar teeth. We have investigated the regulation...
Journal Articles
Journal: Development
Development (1999) 126 (23): 5523–5531.
Published: 1 December 1999
... ‡ These authors contributed equally to this work 15 09 1999 09 11 1999 © 1999 by Company of Biologists 1999 Hindbrain Mouse Rhombomere 4 Motor Neurons Hoxb1 GATA2 GATA3 Regulation GATA3 is a member of the family of transcription factors that have recently emerged...
Journal Articles
Journal Articles
Journal: Development
Development (1998) 125 (6): 1095–1101.
Published: 15 March 1998
...George N. Serbedzija; Jau-Nian Chen; Mark C. Fishman ABSTRACT In many vertebrates, removal of early embryonic heart precursors can be repaired, leaving the heart and embryo without visible deficit. One possibility is that this ‘regulation’ involves a cell fate switch whereby cells, perhaps...
Journal Articles
Journal Articles
Journal: Development
Development (1998) 125 (2): 201–213.
Published: 15 January 1998
... the reconstituted Hensen’s node and, therefore, acts like a Nieuwkoop Center. These findings increase our understanding of the mechanism of notochord reconstitution, provide new information and a novel model system for studying the induction of the organizer and reveal the potential of the epiblast to regulate its...
Journal Articles
Journal: Development
Development (1996) 122 (10): 3095–3105.
Published: 1 October 1996
... unilaterally by micro-surgery. Of the embryos that survived, about 35% exhibited regulative regeneration, wherein the missing hemi-rhombomere was reconstituted to normal size and morphology through compensatory proliferation and migration from adjacent tissue. The capacity for regener-ation depended...
Journal Articles
Journal: Development
Development (1995) 121 (6): 1691–1703.
Published: 1 June 1995
... that poly-homeotic activation in germ-band-elongated embryos could be mediated by Engrailed-binding to these sites. * Author for correspondence 06 03 1995 © 1995 by Company of Biologists 1995 Several observations support the proposal that ph is a direct target of en regulation...
Journal Articles
Journal: Development
Development (1993) 118 (4): 1049–1062.
Published: 1 August 1993
... bordering the ablated region demonstrate that cells at the same axial level, in the lateral and ventral neural tube, regulate to reconstitute a population of neural crest cells. These cells emigrate from the neural tube, migrate along normal pathways according to their axial level of origin and appear...
Journal Articles
Journal: Development
Development (1993) 117 (3): 977–991.
Published: 1 March 1993
... in this respect, also fails to fulfil some of the predictions of the autoregulatory model ( Katz et al., 1990 ). Although this yeast does down-regulate tubulin accumulation in response to increased gene dosage, there is no corresponding up-regulatory response when gene dosage is decreased. The relevance...
Journal Articles
Journal: Development
Development (1993) 117 (1): 283–291.
Published: 1 January 1993
... that requires the activity of other segment polarity genes including patched ( ptc ) and hedgehog ( hh ). Here we present further evidence that ptc and hh encode components of a signal transduction pathway that regulate the expression of wg transcription following its activation by pair-rule genes. We also show...
Journal Articles