... in adult zebrafish. Using a newly generated CreER T2 transgenic line, we show that the cells directing expression of the bridging glial marker ctgfa give rise to regenerating glia after injury, with negligible contribution to either neuronal or oligodendrocyte lineages. A 1 kb sequence upstream...

... provided that the original work is properly attributed. Highlighted Article: Relative intercellular asymmetry is a crucial factor underlying the robustness of persistently directional collective cell rotations in vivo . Multicellular rotations Patterning Regeneration Symmetry breaking...

...Sorrel Tran; Yun-Fan Stephanie Chen; Dawei Xu; Madalene Ison; Li Yang ABSTRACT De novo root regeneration (DNRR) is a developmental process that regenerates adventitious roots from wounded tissues. Phytohormone signaling pathways involved in microbial resistance are mobilized after cutting...

... on cardiomyocyte proliferation during postnatal development, we sought to evaluate whether Runx1 can similarly induce cardiomyocyte proliferation and myocardial regeneration in an injury context. Here, we simulated myocardial infarction (MI) by permanent ligation of the left anterior descending (LAD) artery...

... ;HoxA flox/flox and HoxA flox/flox control mice 3 days after tibial defect repair. (J) Experimental plan to test the requirement of multiple posterior Hox genes to generate osteoblasts during bone regeneration of Col1a1 CreERT ;Rosa Tomato mice. (K) The frequency of Tomato + , osteo-lineage...

...Aldine R. Amiel; Stephanie L. Tsai; Daniel Wehner ABSTRACT The eighth EMBO conference in the series ‘The Molecular and Cellular Basis of Regeneration and Tissue Repair’ took place in Barcelona (Spain) in September 2022. A total of 173 researchers from across the globe shared their latest advances...

... and increased cell death leading to IVD degeneration. Moreover, Ccn2a overexpression promotes regeneration through accelerating cell proliferation and suppressing cell death in wild-type aged IVDs. Mechanistically, Ccn2a maintains IVD homeostasis and promotes IVD regeneration by enhancing outer annulus fibrosus...

... organoids in vitro from embryonic, fetal and adult cells, as well as pluripotent stem cells. We discuss how these systems have been used to learn new aspects of pancreas development, regeneration and disease, as well as their limitations and potential for future discoveries. * Author for correspondence...

... of microbial symbionts . Nat. Rev. Microbiol. 8 , 218 - 230 . 10.1038/nrmicro2262 Brockes , J. and Kumar , A. ( 2008 ). Comparative aspects of animal regeneration . Annu. Rev. Cell Dev. Biol. 24 , 525 - 549 . 10.1146/annurev.cellbio.24.110707.175336 Brooks...

... regenerate. In contrast, a graft of area opaca (without the posterior region) induced a thin ring of ASTL expression in the adjacent area pellucida in some embryos (5/13 with expression) ( P =0.0954, Boschloo's test) ( Fig. 1 F). Likewise, the isolated area opaca did not express ASTL (0/13; Fig. S1C...

...Hannah Brunsdon; Alessandro Brombin; Samuel Peterson; John H. Postlethwait; E. Elizabeth Patton ABSTRACT Melanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but metabolic programs associated with their activation and regenerative...

... repair by scar formation and the initiation of tissue regeneration. They initially assume inflammatory phenotypes, releasing pro-inflammatory cytokines and removing dead and dying tissue, before entering a reparative stage, replacing dead muscle tissue with a non-contractile scar. In this Review, we...

...Amanda S. Janesick; Mirko Scheibinger; Nesrine Benkafadar; Sakin Kirti; Stefan Heller ABSTRACT The avian hearing organ is the basilar papilla that, in sharp contrast to the mammalian cochlea, can regenerate sensory hair cells and thereby recover from deafness within weeks. The mechanisms...

... repair and regeneration. We conclude by suggesting that comprehensive analyses of the immune system may enable biomedical applications in stem cell biology and regenerative medicine. National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R01GM132753...

...Nicolle A. Bonar; David I. Gittin; Christian P. Petersen ABSTRACT Tissue identity determination is crucial for regeneration, and the planarian anteroposterior (AP) axis uses positional control genes expressed from body wall muscle to determine body regionalization. Canonical Wnt signaling...

... in skeletal muscle regeneration and, in the absence of eosinophil-secreted interleukin (IL) 4 and IL13, fibro-adipogenic progenitors fail to support muscle stem cell proliferation. However, the role of eosinophils in muscular dystrophy remains elusive. Although it has been shown that eosinophils are present...

...Timothy J. Duerr; Eun Kyung Jeon; Kaylee M. Wells; Antonio Villanueva; Ashley W. Seifert; Catherine D. McCusker; James R. Monaghan ABSTRACT Regulation of cell cycle progression is essential for cell proliferation during regeneration following injury. After appendage amputation, the axolotl...

... that canonical Notch signaling is induced during the initial stages of cartilage callus formation in both mesenchymal cells and chondrocytes following surgical mandibulectomy. We also show that modulation of Notch signaling during the initial post-operative period results in lasting changes to regenerate bone...

... of retinal regeneration varies greatly across vertebrate species. In the fish, retinal regeneration is a robust process that restores functional cells and visual acuity following injury, whereas this process is far less robust in birds and is absent in mammals ( Hitchcock and Raymond, 1992 ; Karl et al...

...Phanu T. Serivichyaswat; Kai Bartusch; Martina Leso; Constance Musseau; Akira Iwase; Yu Chen; Keiko Sugimoto; Marcel Quint; Charles W. Melnyk ABSTRACT Cellular regeneration in response to wounding is fundamental to maintain tissue integrity. Various internal factors including hormones...