.... Here, we review proneural bHLH gene evolution and function in the Drosophila and vertebrate nervous systems, arguing that the Drosophila gene atonal provides a useful platform for understanding proneural gene structure and regulation. We also discuss how functional equivalency experiments using...

...Sini-Maaria Virolainen; Kaia Achim; Paula Peltopuro; Marjo Salminen; Juha Partanen Diverse mechanisms regulate development of GABAergic neurons in different regions of the central nervous system. We have addressed the roles of a proneural gene, Ascl1 , and a postmitotic selector gene, Gata2...

...Romain Madelaine; Laurence Garric; Patrick Blader Little is known about proneural gene function during olfactory neurogenesis in zebrafish. Here, we show that the zebrafish Atonal genes neurogenin1 ( neurog1 ) and neurod4 are redundantly required for development of both early-born olfactory neurons...

... to a hair-cell fate. * Authors for correspondence (e-mails: nsegil@hei.org ; agroves@hei.org ) 19 9 2007 © 2007. 2007 Proneural gene bHLH Hair cells Inner ear Otocyst Neurogenesis During ear development, diverse components of a sensory pathway - neurons,mechanosensory...

... the naive state of marginal progenitor cells by attenuating the expression of both proneural and neurogenic genes, thus preventing those cells from launching out into the differentiation cascade regulated by proneural genes and Notch. † Author for correspondence (e-mail: nakagawas@riken.jp...

... ectoderm. The proneuronal domains are prefigured by the expression of basic helix-loop-helix (bHLH) proneural genes,and separated by domains (inter-proneuronal domains) that do not express the proneural genes. Little is known about how the formation of these domains is spatially regulated. We have found...

... ) 16 12 2003 © 2004. 2004 Neural precursor Drosophila Xenopus bHLH Proneural gene Evolution The development of multicellular organisms involves a complex interplay of pathways regulating gene expression and mediating cell-cell interactions. Most of these pathways...

...-Horowicz, D. and Kintner, C. ( 1995 ). Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene Delta. Nature 375 , 761 -766. Chitnis, A. and Kintner, C. ( 1996 ). Sensitivity of proneural genes to lateral inhibition affects the pattern of primary neurons...

... the relative timing of cell cycle exit in the developing Xenopus retina and asked whether this affected the activity of neural determinants. We found that Xath5 , a bHLH proneural gene that promotes retinal ganglion cell (RGC) fate, ( Kanekar, S., Perron, M., Dorsky, R., Harris, W. A., Jan, L. Y., Jan, Y. N...

... by Company of Biologists 2000 Neurogenesis C. elegans Male tail Sublineage lin-32 hlh-2 bHLH Proneural gene The development of the multiple cell types of a metazoan organism requires that precursor cells pass through a variety of intermediate cell states as cells become...

...Andrew P. Jarman; Yan Sun; Lily Y. Jan; Yuh Nung Jan ABSTRACT The Drosophila gene atonal encodes a basic helix-loop-helix protein similar to those encoded by the proneural genes of the achaete–scute complex (AS-C). The AS-C are required in the Drosophila PNS for the selection of neural precursors...