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Keywords: proliferation
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Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201045.
Published: 17 July 2023
... requires a careful balance between cellular proliferation and differentiation. Premature or delayed differentiation, for instance, can result in tissue imbalance, malformation or malfunction. Despite seemingly rigid constraints on development, however, there is flexibility in both the timing...
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (7): dev201318.
Published: 13 April 2023
... strains, C57BL/6J and A/J, reveals involvement of Tnni3k and Runx1 in divergent developmental paths to differing final ploidy composition in myocardium. Cardiomyocyte Somatic polyploidy Endomitosis Proliferation Regeneration American Heart Association http://dx.doi.org/10.13039...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (22): dev191957.
Published: 28 November 2022
...Krista M. Angileri; Nornubari A. Bagia; Cedric Feschotte ABSTRACT Tissue regeneration requires precise temporal control of cellular processes such as inflammatory signaling, chromatin remodeling and proliferation. The combination of these processes forms a unique microenvironment permissive...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200195.
Published: 1 February 2022
...André Rosa; Wolfgang Giese; Katja Meier; Silvanus Alt; Alexandra Klaus-Bergmann; Lowell T. Edgar; Eireen Bartels-Klein; Russell T. Collins; Anna Szymborska; Baptiste Coxam; Miguel O. Bernabeu; Holger Gerhardt ABSTRACT Endothelial cell migration and proliferation are essential for the establishment...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev194407.
Published: 24 January 2022
.... ( 2006 ). Mitf regulation of Dia1 controls melanoma proliferation and invasiveness . Genes Dev. 20 , 3426 - 3439 . 10.1101/gad.406406 Chi , G. F. , Kim , D. W. , Jiang , M. H. , Yoon , K. J. and Son , Y. ( 2011 ). Schwann-like cells from human melanocytes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199740.
Published: 13 September 2021
...Hessel Honkoop; Phong D. Nguyen; Veronique E. M. van der Velden; Katharina F. Sonnen; Jeroen Bakkers ABSTRACT Zebrafish are excellent at regenerating their heart by reinitiating proliferation in pre-existing cardiomyocytes. Studying how zebrafish achieve this holds great potential in developing new...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev193409.
Published: 25 January 2021
.... In contrast, cartilage overgrowth and scoliosis are absent in rare viable nkx3.2 knockdown animals that lack jaw joints, supporting post-embryonic roles for Nkx3.2. Single-cell RNA-sequencing and in vivo validation reveal increased proliferation and upregulation of stress-induced pathways, including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev190231.
Published: 11 June 2020
.... Highlighted Article: In the Drosophila wing, the Argonaute family protein AGO1 acts independently of the miRNA-silencing pathway to restrict tissue growth by directly repressing transcription of the master growth regulator Myc. Argonaute Drosophila Myc Proliferation Psi Transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
...Zhen Shi; Cindy Lim; Vuong Tran; Kairong Cui; Keji Zhao; Xin Chen ABSTRACT The Drosophila male germline stem cell (GSC) lineage provides a great model to understand stem cell maintenance, proliferation, differentiation and dedifferentiation. Here, we use the Drosophila GSC lineage to systematically...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (2): dev180695.
Published: 23 January 2020
... generation by negatively regulating oligodendrocyte precursor cell (OPC) proliferation. GDE3 inhibits OPC proliferation by stimulating ciliary neurotrophic factor (CNTF)-mediated signaling through release of CNTFRα, the ligand-binding component of the CNTF-receptor multiprotein complex, which can function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev178632.
Published: 9 October 2019
...Raz Ben-Yair; Vincent L. Butty; Michele Busby; Yutong Qiu; Stuart S. Levine; Alon Goren; Laurie A. Boyer; C. Geoffrey Burns; Caroline E. Burns ABSTRACT Deciphering the genetic and epigenetic regulation of cardiomyocyte proliferation in organisms that are capable of robust cardiac renewal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (9): dev178087.
Published: 9 May 2019
... levels of GATAe gene expression in tubule principal cells induce uncontrolled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Furthermore, we uncover the involvement of GATAe in the maintenance of stellate cells and migration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev170753.
Published: 1 February 2019
... is essential for cardiomyocyte proliferation and cardiogenesis. Mosaic Myc overexpression in a Mycn -deficient background shows that Myc can replace Mycn function, recovering heart development. We further show that this recovery involves the elimination of Mycn-deficient cells by cell competition. Our results...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev167643.
Published: 29 January 2019
... and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates. * Author for correspondence ( erika.bach@nyu.edu ) Competing interests The authors declare no competing or financial interests. 10 9 2018 3 12...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (1): dev166595.
Published: 9 January 2019
.... Here, we study how increased cell number evolved in the vertebrate central nervous system, investigating the regulation of cell proliferation in the lamprey spinal cord. Markers of proliferation show that a ventricular progenitor zone is found throughout the lamprey spinal cord. We show that inhibition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev161182.
Published: 2 July 2018
... that Cdc42 is required for endothelial tip cell selection, directed cell migration and filopodia formation, but dispensable for cell proliferation or apoptosis. Although the loss of Cdc42 seems generally compatible with apical-basal polarization and lumen formation in retinal blood vessels, it leads...
Includes: Supplementary data