... proliferation and differentiation is context dependent. Foxn1 Thymus Medullary TEC Progenitor cells Proliferation Thymic epithelial cells National Institutes of Health http://dx.doi.org/10.13039/100000002 P01AG052359-01A1 University of Georgia http://dx.doi.org/10.13039...

... Progenitor cells RNA velocity Type 1 pneumocyte Mouse Francis Family Foundation http://dx.doi.org/10.13039/100005834 National Institutes of Health http://dx.doi.org/10.13039/100000002 K08HL143051 K08HL130595 R01HL153246 R01HL145372 P01HL092470 K08HL127102 R03HL154287...

... such as the esophagus. However, the molecular mechanisms regulating these progenitor activities in the esophagus remain to be elucidated. Here, we demonstrated that Yap is required for the proliferation of esophageal progenitor cells (EPCs) in the developing murine esophagus. We found that Yap deficiency reduces EPC...

...: Rhombomeric boundary cells act as mechanosensors through Yap/Taz-TEAD activity, affecting progenitor maintenance and therefore balancing proliferation and differentiation. Boundaries Compartments Mechanical cues Progenitor cells Neurons Hindbrain Yap/Taz Understanding how progenitor cell...

.... Yap Branching morphogenesis Airway differentiation Progenitor cells Lung development Alveolar differentiation The generation of organs with complex three-dimensional (3D) tubular architecture and distinct functional compartments, such as the mammary gland, kidney and lung, requires...

...Jacqueline L. Norrie; Qiang Li; Swanie Co; Bau-Lin Huang; Ding Ding; Jann C. Uy; Zhicheng Ji; Susan Mackem; Mark T. Bedford; Antonella Galli; Hongkai Ji; Steven A. Vokes During embryonic development, undifferentiated progenitor cells balance the generation of additional progenitor cells...

..., has not yet been achieved for continuously growing adult tissues, but is essential if we wish to understand the architecture of adult organs. The retinas of lower vertebrates grow throughout life from retinal stem cells (RSCs) and retinal progenitor cells (RPCs) at the rim of the retina, called...

... to quantify the regenerative potential of human mammary cells. Mammary stem cell Primary human mammary epithelial cells Basal Luminal Progenitor cells Branching morphogenesis Organoid Regenerative potential CD10 Terminal ductal-lobular units Collagen gel The mammary gland (MG) develops...

... of expansion and proliferation. The mammary gland thus provides an excellent model for studying the ‘stem/progenitor’ cells that allow this repeated expansion and renewal. In this Review, we provide an overview of the different cell types that constitute the mammary gland, and discuss how these cell types...

... for homeostasis and repair of the conducting airways. Little is known about how these progenitor cells expand and transition to differentiation to form the pseudostratified airway epithelium in the developing and adult lung. Here, we show by genetic and pharmacological approaches that endogenous activation...

... ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Clonal lineage CRE recombinase piggyBac transposase Multi-fluorescence Progenitor cells Fate mapping...

... of fetal cells (fetal cortex derived Gli1 -expressing cells and mesenchymal Tcf21 -expressing mesenchymal cells) participate in the establishment of the homeostatic capsular progenitor cell niche of the adult cortex. ‡ Author for correspondence ( ghammer@umich.edu ) * Present address: Magee...

... expressed in early retinal progenitor cells and that Sox4 expression began around birth, when expression of Sox11 subsided. To analyze the roles of Sox11 and Sox4 in retinal development, we perturbed their expression patterns in retinal explant cultures. Overexpression of Sox11 and Sox4 in retinal...

... of the trunk. The NMs are deposited by a migrating pLL primordium, which is organized into polarized rosettes (proto-NMs). During migration, mature proto-NMs are deposited from the trailing part of the primordium, while progenitor cells in the leading part give rise to new proto-NMs. Wnt signaling is active...

... declare no competing financial interests. 23 2 2011 © 2011. 2011 Cadherin Neural tube Chick RNAi Screen FatJ Progenitor cells Interneurons Phenotype Hippo pathway Notch signalling Morphogen Neural progenitor cells are patterned along the dorsoventral axis...

... progenitor cell identity at the expense of differentiated cell phenotypes, we test whether genetic activation of Notch could rescue the Eya1 −/− lung phenotype, which is characterized by loss of epithelial progenitors, increased epithelial differentiation but reduced branching. Indeed, genetic activation...

... complete organ failure to congenital hypertension. A balance between differentiation and maintenance of a mesenchymal progenitor cell population determines the final number of nephrons. How this balance is struck is poorly understood. Previous studies have suggested that Wnt9b/β-catenin signaling induced...

... ). Is there a single self-renewing Id2 + progenitor cell type during the pseudoglandular stage? Or, are there separate bronchiolar and alveolar progenitors? To distinguish between these possibilities, we identified a dose of tmx that labeled either a single tip epithelial cell, or no cells, per lung. We exposed...

... Progenitor cells Forebrain Diencephalon ZLI Prethalamus Thalamus Pretectum Zinc finger The vertebrate forebrain is a tremendously complex structure and carries out essential functions such as regulating emotions, learning and memory, and hormonal homeostasis. It arises from anterior...

...Fumi Kubo; Masatoshi Takeichi; Shinichi Nakagawa During the development of the central nervous system, cell proliferation and differentiation are precisely regulated. In the vertebrate eye, progenitor cells located in the marginal-most region of the neural retina continue to proliferate for a much...