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Keywords: prdm1
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Journal Articles
Journal: Development
Development (2020) 147 (13): dev190272.
Published: 3 July 2020
...Noah B. Goodson; Michael A. Kaufman; Ko U. Park; Joseph A. Brzezinski, IV ABSTRACT The transcription factor OTX2 is required for photoreceptor and bipolar cell formation in the retina. It directly activates the transcription factors Prdm1 and Vsx2 through cell type-specific enhancers. PRDM1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev181107.
Published: 16 December 2019
... is still debated. Here, we identify a crucial role for the transcription factor PRDM1 in the orderly transition from epiblast to defined neural lineages in chick. PRDM1 is initially expressed broadly in the entire epiblast, but becomes gradually restricted as cell fates are specified. We find that PRDM1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (10): 1663–1673.
Published: 15 May 2016
... mammary gland, Blimp1 marks a rare progenitor population, and is required for cell proliferation and polarity as well as efficient milk production. Blimp1 Prdm1 Transcriptional repressor Mammary gland morphogenesis Luminal progenitors Polarity Lumen formation 3D culture Mouse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 255–263.
Published: 15 January 2016
... cell formation. In order to gain further insight into the functional evolution of germ cell specification, here we examined the Gryllus ortholog of the transcription factor Blimp-1 (also known as Prdm1 ), which is a widely conserved bilaterian gene known to play a crucial role in the specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (16): 3445–3455.
Published: 15 August 2013
... ) Competing interests statement The authors declare no competing financial interests. 19 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 Blimp1 Neural crest Neural plate border Prdm1 Neural crest cells (NCCs) are a transient population of stem cell-like...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (20): 4399–4404.
Published: 15 October 2011
... interests. 10 8 2011 © 2011. Sox6 Translational control miR-499 ( mir499 ) Muscle fibre type Zebrafish Prdm1 During skeletal myogenesis in vertebrates, mesodermally derived muscle progenitor cells give rise to myoblasts that in turn differentiate into either slow...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 403–414.
Published: 1 February 2009
... ) myod myf5 Myogenin Hedgehog prdm1 pax3 meox1 hsp90 mef2d Here, we turn to zebrafish in the hope of finding shared and divergent roles for individual MRFs in myogenesis. Each zebrafish somite generates at least four populations of muscle fibres within the first 15 hours...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (12): 2115–2126.
Published: 15 June 2008
... show here that different subsets of these slow fibres express distinct members of a tandem array of slow MyHC genes. The first slow twitch muscle fibres to differentiate, which are specified by the activity of the transcription factor Prdm1 (also called Ubo or Blimp1) in response to Hedgehog (Hh...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (13): 2511–2519.
Published: 1 July 2007
... Myosin Muscle Zebrafish Myofibril Somite tnnc Myogenin Hoover prdm1 eng2a acta1 actc1 smyhc1 myhz1 tpma mybpc1 hsp90a Skeletal myogenesis involves three steps: (1) commitment of proliferative mesodermal cells as myoblasts, (2) terminal differentiation, often...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (15): 2805–2815.
Published: 1 August 2006
... regulatory hierarchy has not been determined in any species. tbx5 is the earliest gene expressed in the limb bud mesenchyme. Recently, another transcription factor, Prdm1, has been shown to be crucial for zebrafish forelimb development. Here, we show that Prdm1 is downstream of RA, Wnt2b and Tbx5 activity...