... of E2f1 destruction should permit us to directly test whether prevention of E2f1 destruction would affect replication factor gene expression in the embryo. E2F is necessary for the development of worms, flies and mice( DeGregori, 2002 ). Remarkably,however, pRb is not needed for the entirety...

...Woo Chi; Valerie Reinke In Caenorhabditis elegans , EFL-1 (E2F), DPL-1 (DP) and LIN-35(pRb) act coordinately in somatic tissues to inhibit ectopic cell division,probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act...

... role for cki-1 Cip/Kip rather than lin-35 Rb explains the lack of cell-cycle phenotype of lin-35 mutant animals. C. elegans Cyclin CDK pRb Cip/Kip Cell cycle The development of a multicellular organism requires the careful coordination of cell division with growth and differentiation...

... that the product of the retinoblastoma gene (pRb) may also be involved in this pathway. Previously, we have shown that TGF-β1 inhibits branching morphogenesis and N- myc expression in mouse embryonic lung cultures. The purpose of this study was to determine the role of pRb in the inhibition of branching...