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Keywords: otx2
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198549.
Published: 30 April 2021
... to the identification of many cis -regulatory modules (CRMs) active in cone/HC RPCs and developing cones. Two transcription factors, Otx2 and Oc1, were found to bind to many of these CRMs, including those near genes important for cone development and function, and their binding sites were required for activity. We also...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (5): dev159640.
Published: 12 March 2018
...Yumeko Satou; Kohei Minami; Erina Hosono; Hajime Okada; Yuuri Yasuoka; Takashi Shibano; Toshiaki Tanaka; Masanori Taira ABSTRACT The homeodomain transcription factor Otx2 has essential roles in head and eye formation via the negative and positive regulation of its target genes, but it remains...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (20): 3859–3867.
Published: 15 October 2014
...Chi Kin Ip; Nicolas Fossat; Vanessa Jones; Thomas Lamonerie; Patrick P. L. Tam The Otx2 gene encodes a paired-type homeobox transcription factor that is essential for the induction and the patterning of the anterior structures in the mouse embryo. Otx2 knockout embryos fail to form a head. Whereas...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (2): 389–398.
Published: 15 January 2014
... of this construct in chick through electroporation at E2 into the midbrain-hindbrain region. Ectopic dn-fgfr3c was sufficient to ablate Sprouty2 expression at the isthmus at E3 ( supplementary material Fig. S1A -C) and induce a caudal expansion of Otx2 -positive midbrain tissue at the expense of Gbx2...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (21): 3926–3937.
Published: 1 November 2012
... the epiblast state and ANP development depending on their balance. Analyses of the effects of knockdown and overexpression of these factors in EpiSCs on the levels of downstream transcription factors identified the following regulatory functions: cross-regulation among Zic, Otx2, Sox2 and Pou factors...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 725–734.
Published: 15 February 2011
...N. Abimbola Sunmonu; Kairong Li; Qiuxia Guo; James Y. H. Li In vertebrates, the common expression border of two homeobox genes, Otx2 and Gbx2 , demarcates the prospective midbrain-hindbrain border (MHB) in the neural plate at the end of gastrulation. The presence of a compartment boundary...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2009) 136 (15): 2545–2555.
Published: 1 August 2009
.... We show that Otx2 provides the crucial anterior-posterior positional information for the generation of red nucleus neurons in the murine midbrain. Moreover, the homeodomain transcription factor Nkx6-1 controls the proper development of the red nucleus and of the oculomotor and trochlear nucleus...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (23): 4243–4253.
Published: 1 December 2007
... hormone receptor that is required for the development of green cone photoreceptors. Nat. Genet. 27 , 94 -98. Nishida, A., Furukawa, A., Koike, C., Tano, Y., Aizawa, S.,Matsuo, I. and Furukawa, T. ( 2003 ). Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development...
Journal Articles
Journal Articles
Journal: Development
Development (2006) 133 (10): 1891–1900.
Published: 15 May 2006
... transformation of the anterior r1 into mesencephalon ( Jaszai et al., 2003 ). Thus, embryos with lowered level of Otx proteins in an fgf8 -/- /ace background are expected to lack both msencephalon and r1. Zebrafish fgf8 -/- embryos were injected with the combination of otx1-like and otx2 morpholinos...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 89–98.
Published: 1 January 2006
... in close vicinity to developing midbrain dopaminergic neurons. Here, we show that Wnt1 regulates the genetic network, including Otx2 and Nkx2-2, that is required for the establishment of the midbrain dopaminergic progenitor domain during embryonic development. In addition, Wnt1 is required for the terminal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (14): 3209–3216.
Published: 15 July 2005
... their distribution at later developmental stages. In the zebrafish, the expression domains of the transcription factors otx2 and gbx1 (the functional homolog of gbx2 in the mouse) become mutually exclusive towards the end of gastrulation, at the 80% epiboly stage ( Rhinn et al.,2003 ). We therefore...
Includes: Multimedia, Supplementary data