...Ke Tang; Xin Xie; Joo-In Park; Milan Jamrich; Sophia Tsai; Ming-Jer Tsai Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development. The establishment of dorsal/ventral polarity, especially dorsal specification in the optic vesicle...

...Sanghee Yun; Yukio Saijoh; Karla E. Hirokawa; Daniel Kopinke; L. Charles Murtaugh; Edwin S. Monuki; Edward M. Levine A crucial step in eye organogenesis is the transition of the optic vesicle into the optic cup. Several transcription factors and extracellular signals mediate this transition...

... ) * These authors contributed equally to this work 9 11 2005 © 2006. 2006 Retinoids Forebrain development Eye development Neural crest Telencephalon Diencephalon Optic vesicle Pituitary Sonic hedgehog FGF Mouse Aldh1a2 The embryonic forebrain...

... invagination of the lens placode caused by deficient proliferation. Chimera analyses suggest that the lens placode is affected in a cell-autonomous manner, although Mab21l1 is expressed in both the lens placode and the optic vesicle. The defects in lens placode development correlate with delayed...

... and the retinal pigment epithelium in the eye. The molecular mechanisms that pattern neural and non-neural tissues within the neuroectoderm remain unknown. We report that FGF9 is normally expressed in the distal region of the optic vesicle that is destined to become the neural retina, suggesting a role in neural...

...Sylke Winkler; Felix Loosli; Thorsten Henrich; Yuko Wakamatsu; Joachim Wittbrodt ABSTRACT In early vertebrate eye development, the retinal anlage is specified in the anterior neuroectoderm. During neurulation, the optic vesicles evaginate from the lateral wall of the prosencephalon. Here we...

...Jeanette Hyer; Tatsuo Mima; Takashi Mikawa ABSTRACT Patterning of the bipotential retinal primordia (the optic vesicles) into neural retina and retinal pigmented epithelium depends on its interaction with overlaying surface ectoderm. The surface ectoderm expresses FGFs and the optic vesicles...

... mRNA expression in the mouse during normal eye and nasal development. There are two principal components of the early eye, the neural ectoderm of the optic vesicle, which forms the retina, and the overlying surface ectoderm, which forms the lens and cornea. By studying these interacting tissues...

...Catrin Pittack; Gerald B. Grunwald; Thomas A. Reh ABSTRACT During eye development, optic vesicles evaginate laterally from the neural tube and develop into two bilayered eye cups that are composed of an outer pigment epithelium layer and an inner neural retina layer. Despite their similar embryonic...

... mRNA expression in the mouse during normal eye and nasal development. There are two principal components of the early eye, the neural ectoderm of the optic vesicle, which forms the retina, and the overlying surface ectoderm, which forms the lens and cornea. By studying these interacting tissues...

... © 1990 by Company of Biologists 1990 neurogenesis paired box Pax optic vesicle otic vesicle mouse embryology The mammalian central nervous system is a highly evolved network of interconnected cells designed to sense, store and process information. Implicit in its design...

...Brigid L. M. Hogan; Elizabeth M. A. Hirst; Gwynn Horsburgh; Colin M. Hetherington ABSTRACT Small eye ( Sey ) is a dominant mutation in the mouse affecting the embryonic development of the eyes and nose. In homozygous Sey/Sey embryos, the optic vesicles grow out but there is no lens induction...

...Robert M. Grainger; Jonathan J. Henry; Robert A. Henderson The induction of the lens by the optic vesicle in amphibians is often cited as support for the view that a single inductive event can lead to determination in a multipotent tissue. This conclusion is based on transplantation experiments...

...Kathy K. H. Svoboda; K. Sue O’Shea ABSTRACT The optic vesicle develops as an evagination of the cephalic neural folds. We have examined the early development of the optic vesicle in Swiss Webster mice using correlated transmission electron microscopy (TEM), scanning electron microscopy (SEM), light...