... of the cells have committed to neuronal differentiation. We further performed Dll4/Notch1/tdTom immunofluorescence staining after Ascl1Cre ERT2 /R26tdTom tracing at 3 dpi ( Fig. 4 D). As expected, we saw Dll4 + /tdTom + and Notch1 + /tdTom + double positive cells mostly in the marginal and basal zones...

... system . G3 (Bethesda) 10 , 1949 - 1962 . 10.1534/g3.120.401126 Coppola , E. , d'Autreaux , F. , Rijli , F. M. and Brunet , J. F. ( 2010 ). Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation . Development 137 , 4211 - 4220...

.... elegans touch receptor neurons by inhibiting a TEA domain-containing repressor, revealing its role in neuronal fate choice. Cell fate Neuronal differentiation Binary decision Repressors Touch receptor neurons ZEB The terminally differentiated state or cell fate of neurons distinguishes...

...-neural TF that represses dacapo . In addition to its effects on Asense and Prospero, Mnb also promotes the expression of the neuronal-specific RNA regulator Elav, strongly suggesting that Mnb facilitates neuronal differentiation. These actions of Mnb ensure the precise timing of neuronal birth, coupling...

...) in the zebrafish hindbrain. Delays in differentiation are reduced by knocking down N-cadherin, a manipulation expected to help destabilize adherens junctions (AJs). This suggested that delays in neuronal differentiation in epb41l5 -deficient embryos are related to a previously described role for Epb41l5...

... the developmental timing of this transition have not been fully elucidated, gradual elongation in the length of the cell cycle and coinciding accumulation of determinants that promote neuronal differentiation might function as a biological clock that regulates the onset of asymmetric division and neurogenesis. We...

... for neuronal differentiation and brain expansion . Cell Death Differ. 19 , 692 – 702 . Funding This work was supported by grants from the American Cancer Society [RSG-08-045-01-DDC] and the National Brain Tumor Society to N.D. We thank Drs Rachel Brewster, Douglas Epstein, Ellen Heber...

...Christopher Hindley; Fahad Ali; Gary McDowell; Kevin Cheng; Alison Jones; Francois Guillemot; Anna Philpott Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD , while simultaneously controlling progenitor maintenance non...

..., we provide here a genetic characterization of the functions of the transcription factor Bcl11a in neuronal differentiation and the formation of sensory circuits. By the identification of Frzb, we link the transcriptional function of Bcl11a to its role in the guidance of sensory neurons. We...

... that occurs as development progresses. However, the mechanistic basis of this regulation is unknown. The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuronal differentiation. Here, we demonstrate that Ngn2 is phosphorylated on multiple serine-proline sites in response...

... of the NOTCH intracellular domain (NICD), stimulated Delta1 expression and was required for the neuronal differentiation induced by the decrease in NOTCH signaling. Nevertheless, although Mnb/Dyrk1a GoF led to extensive withdrawal of neuronal precursors from the cell cycle, it was insufficient to elicit...

... nuclei. Similarly, maintenance of noradrenergic differentiation during embryogenesis requires ongoing expression of Phox2b in sympathetic ganglia, and of Phox2a in the main noradrenergic center, the locus coeruleus. These data illustrate cases where the neuronal differentiation program does not unfold...

... on retinoblast cell cycle kinetics: id2a -overexpressing retinoblasts progress from S to M phase more rapidly and they undergo mitosis more frequently, which results in macrophthalmia. Mosaic analyses reveal that Id2a function in facilitating both cell cycle progression and neuronal differentiation in the retina...

... 2009. 2009 Apoptosis Chick Delamination Msx1 Noggin Wnt1 Neural crest Neuronal differentiation Neural crest cells (NCCs) are a population of cells unique to vertebrates,which migrate from the dorsal aspect of the neural tube (NT) soon after its formation ( Le...

...-labeling for BrdU and MAP2a/b ( Fig. 2E ). Fig. 2. Hippocampal cultures express markers of cell cycle inhibition and neuronal differentiation after incubation in CM Cerebellum . (A-D) Western blots and/or immunofluorescence staining show that addition of CM Cerebellum (10 μl/ml) to hippocampal...

... for Parkinson’s disease. * Author for correspondence (e-mail: horst.simon@urz.uni-heidelberg.de ) 17 2 2004 © 2004. 2004 Transcription factors Ventral tegmentum Neurodegenerative disease Neuronal survival Neuronal differentiation The pathological hallmark of Parkinson’s...

... ) 2 10 2003 © 2004. 2004 Hydra Nematocyte Neural development Neuronal differentiation Zic odd-paired achaete-scute Nowa The evolution of nervous systems in animals provided them with a major advantage, as they could sense their environment and actively respond...

... positioning along the neurogenic cascade. During neurogenesis, cell cycle exit appears to be tightly coupled to migration to the mantle layer and to neuronal differentiation. We show that antagonizing Ebf gene activity allows the uncoupling of these processes. Ebf gene function is necessary to initiate...

... system Zebrafish AP-2 Hindbrain Mont blanc Lockjaw Retinoic acid Neuronal differentiation Noradrenergic neurons of the brain stem play a major role in modulating sensory, motor and arousal tone in vertebrates. Several evolutionary conserved noradrenergic (NA) centers exist...

... Neuronal differentiation Mouse To generate the diversity of vertebrate central nervous system (CNS)neurons, neuronal progenitors must receive positional information along the anteroposterior (AP) and dorsoventral (DV) axes during development. The signals that confer such positional information...