...Shinjini Ray; Priti Agarwal; Anat Nitzan; François Nédélec; Ronen Zaidel-Bar ABSTRACT Actin dynamics play an important role in tissue morphogenesis, yet the control of actin filament growth takes place at the molecular level. A challenge in the field is to link the molecular function of actin...

..., distribution and reproduction in any medium provided that the original work is properly attributed. Highlighted Article: EGF receptor signaling in Drosophila protects epithelial tissues under mechanical stress from collapsing by preventing apical cell extrusion. Morphogenesis Invagination...

...Dina J. Ashour; Clinton H. Durney; Vicente J. Planelles-Herrero; Tim J. Stevens; James J. Feng; Katja Röper During morphogenesis, large-scale changes of tissue primordia are coordinated all across an embryo. In Drosophila, several tissue primordia and embryonic regions are bordered or encircled...

...Pei Zhang; Jiwei Chen; Xiangchuan Wang; Yingchao Geng; Liangyu Sun; Hongjie Zhang ABSTRACT Organ morphogenesis needs orchestration of a series of cellular events, including cell division, cell shape change, cell rearrangement and cell death. Cytokinesis, the final step of cell division, is involved...

...Jeremy B. A. Green ABSTRACT Morphogenesis is extremely diverse, but its systematic quantification to determine the physical mechanisms that produce different phenotypes is possible by quantifying the underlying cell behaviours. These are limited and definable: they consist of cell proliferation...

... its C terminus. The SRGP-1 C terminus is sufficient to target it to adherens junctions, but only during later embryonic morphogenesis, when junctional tension is known to increase. Surprisingly, mutations that disrupt stabilizing salt bridges in the M domain block this recruitment. Loss of SRGP-1...

... by neural plate morphogenesis. Finally, we show that an increase in surface ectoderm resistive forces is detrimental for neural plate morphogenesis. Fig. 2. PCP-mediated cell intercalative behaviour is restricted to the posterior NP. (A) Stills from a time-lapse recording of a neurula-stage embryo...

... almost relentlessly, building plant architecture and morphogenesis. Boundary domains display reduced growth and orchestrate development of adjacent tissues in a non-cell-autonomous manner. How these two functions are achieved remains elusive despite the identification of several boundary-specific genes...

... in Xenopus . Lmo7 Actomyosin contractility Non-muscle myosin II Adherens junctions Morphogenesis Xenopus ectoderm National Institutes of Health R35GM122492 Apical constriction, or reduction in size of the apical domain, underlies a variety of morphogenetic processes during...

... and shape the mammalian embryo. We detail how this can be complemented with precise measurements and manipulations of tissue biochemistry, mechanics and geometry across spatial and temporal scales to provide insights into the mechanochemical feedback loops governing embryo morphogenesis. Finally, we discuss...

...Satoshi Yamashita; Boris Guirao; François Graner ABSTRACT Within developing tissues, cell proliferation, cell motility and other cell behaviors vary spatially, and this variability gives a complexity to the morphogenesis. Recently, novel formalisms have been developed to quantify tissue deformation...

.... and Wittbrodt , J . ( 2009 ) . Ojoplano-mediated basal constriction is essential for optic cup morphogenesis . Development , 136 , 2165 - 2175 . 10.1242/dev.033563 Moreno-Mateos , M. A. , Vejnar , C. E. , Beaudoin , J.-D. , Fernandez , J. P. , Mis , E. K. , Khokha , M. K...

...Brent H. Wyatt; Nirav M. Amin; Kristen Bagley; Dustin J. Wcisel; Michael K. Dush; Jeffrey A. Yoder; Nanette M. Nascone-Yoder ABSTRACT The morphogenesis of left-right (LR) asymmetry is a crucial phase of organogenesis. In the digestive tract, the development of anatomical asymmetry is first evident...

...Toby G. R. Andrews; Wolfram Pönisch; Ewa K. Paluch; Benjamin J. Steventon; Elia Benito-Gutierrez ABSTRACT Embryonic tissues are shaped by the dynamic behaviours of their constituent cells. To understand such cell behaviours and how they evolved, new approaches are needed to map out morphogenesis...

... undergo large scale remodeling involving stem cells, transient amplifying cells and differentiated cells. The control of this homeostasis in physiological and plucked-induced cycling is analyzed. Stem cell niche Dermis Follicle Morphogenesis Evolution Evo-Devo Chicken National...

... morphogenesis is regulated by the relative timing of epithelial versus mesenchymal cell convergence regulated by canonical Wnt signaling. Together, these studies reveal new aspects of Wnt/β-catenin signaling in tooth formation and in epithelial morphogenesis more broadly. * Present address: The Institute...

...Susannah B. P. McLaren; Benjamin J. Steventon ABSTRACT How force generated by the morphogenesis of one tissue impacts the morphogenesis of other tissues to achieve an elongated embryo axis is not well understood. The notochord runs along the length of the somitic compartment and is flanked...

... of a developmental blueprint that defines the polarized organization of the apical cytoskeleton in hair cells, including stereocilia distribution and elongation. Here, we report a role for multiple PDZ domain (MPDZ) protein during apical hair cell morphogenesis in mouse. We show that MPDZ is enriched at the hair...

...David Oriola; Francesca M. Spagnoli ABSTRACT The second EMBO-EMBL Symposium ‘Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture’ was held virtually in March 2021, with participants from all over the world joining from the comfort of their sofas to discuss synthetic morphogenesis...

..., development of technologies for the reconstitution of a three-dimensional trachea from stem cells is urgently required. Recently, single-cell sequencing technologies and quantitative analyses from cell to tissue scale have been employed to decipher the cellular basis of tracheal morphogenesis. In this Review...