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Keywords: miRNA
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Journal Articles
In collection:
Plant development
Journal: Development
Development (2022) 149 (4): dev199974.
Published: 15 February 2022
... of microRNAs (miRNAs). However, the molecular function of submergence stress-induced miRNAs in physiological or developmental changes and recovery remains poorly understood. Here, we show that miR775 is an Arabidopsis thaliana -specific young and unique miRNA that possibly evolved non-canonically. miR775 post...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2020) 147 (9): dev190520.
Published: 11 May 2020
...Martina Dori; Daniel Cavalli; Mathias Lesche; Simone Massalini; Leila Haj Abdullah Alieh; Beatriz Cardoso de Toledo; Sharof Khudayberdiev; Gerhard Schratt; Andreas Dahl; Federico Calegari ABSTRACT MicroRNAs (miRNAs) are short (∼22 nt) single-stranded non-coding RNAs that regulate gene expression...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (3): dev180232.
Published: 3 February 2020
... of cell permeable miRNA inhibitors, siRNA probes and/or drug treatments to either compartment ( Dajas-Bailador et al., 2012 ; Hengst et al., 2009 ; Taylor et al., 2005 ; Zhang et al., 2015 ). Neurons were seeded in the soma side and grown for 5-6 days in order to allow a significant number of axons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3211–3223.
Published: 15 September 2017
... on the complementarity score (score ≥140) and free energy (ΔG≤–14 kcal/mol). Target validation was performed in HEK293T cells transfected with pMIR-REPORT plasmid (Addgene) containing the 3′-UTR of the target and pRL-SV40 containing the Renilla luciferase gene (Promega) as a transfection control. miRNA mimics were...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2017) 144 (11): 1966–1975.
Published: 1 June 2017
... polymorphism in the miRNA binding site. Inhibition of miR172 activity by a miRNA target mimic resulted in compact spikes and transition from glumes to florets in apical spikelets. By contrast, overexpression of miR172 was sufficient to induce elongated spikes and non-free-threshing grains, similar to those...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2016) 143 (18): 3230–3237.
Published: 15 September 2016
... by The Company of Biologists Ltd 2016 Summary: This Review revisits Ian Sussex's early studies of leaf dorsiventrality and describes our current understanding of the mechanisms that establish and maintain adaxial-abaxial leaf polarity. Apical meristem Leaf dorsiventrality Adaxial-abaxial miRNA...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2016) 143 (17): 3061–3073.
Published: 1 September 2016
...? If siRNAs do play a role in the germline, might they interact with the piRNA pathway in a manner similar to WAGO-associated small RNAs in C. elegans , which ensure long-term silencing of transposable elements? Could interactions exist between the miRNA and piRNA pathways? Answering these questions...
Journal Articles
Journal: Development
Development (2014) 141 (9): 1864–1874.
Published: 1 May 2014
...Carlos M. Loya; Elizabeth M. McNeill; Hong Bao; Bing Zhang; David Van Vactor MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that play important roles in nervous system development and physiology. However, our understanding of the strategies by which miRNAs control synapse...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1272–1281.
Published: 15 March 2014
... and actin filaments. For example, loss of Apc in the small intestine reduces the migration of epithelial cells and promotes the formation of polyps ( Oshima et al., 1997 ). Specific microRNAs (miRNAs) have been implicated in both lung development and disease ( Jiang et al., 2010 ; Ornitz and Yin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1882–1891.
Published: 1 May 2013
...Sarah J. Jackson; Zhaojie Zhang; Dejiang Feng; Meaghan Flagg; Evan O’Loughlin; Dongmei Wang; Nicole Stokes; Elaine Fuchs; Rui Yi MicroRNAs (miRNAs) play important roles in differentiation of stem cells. However, the precise dynamics of miRNA induction during stem cell differentiation have not been...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 976–986.
Published: 1 March 2013
... germ layer specification, and that this early function is probably independent of the recognised role of Lin28 proteins in negatively regulating let-7 miRNA biogenesis. Total RNA was isolated using miRVana miRNA Isolation Kit (Applied Biosystems). cDNA was synthesized with miRNA-specific primers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 31–42.
Published: 1 January 2013
... plays an essential role in skeletal muscle regeneration in adult mice. Injured Mef2a knockout mice display widespread necrosis and impaired myofiber formation. MEF2A controls this process through its direct regulation of the largest known mammalian microRNA (miRNA) cluster, the Gtl2-Dio3 locus. A subset...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (12): 2161–2169.
Published: 15 June 2012
... ( vivian.irish@yale.edu ) Competing interests statement The authors declare no competing financial interests. 4 4 2012 © 2012. Arabidopsis miRNA Flower development The formation of boundaries between different cell populations is crucial for development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1405–1416.
Published: 15 April 2012
...Monica Teta; Yeon Sook Choi; Tishina Okegbe; Gabrielle Wong; Oliver H. Tam; Mark M. W. Chong; John T. Seykora; Andras Nagy; Dan R. Littman; Thomas Andl; Sarah E. Millar MicroRNAs (miRNAs) regulate the expression of many mammalian genes and play key roles in embryonic hair follicle development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (9): 1737–1745.
Published: 1 May 2011
...: Department of Zoology, University of Wisconsin, Madison, WI 53706, USA 11 2 2011 © 2011. 2011 miRNA Oogenesis Mitotic-to-endocycle switch Developmental timing Drosophila The development of multicellular organisms requires the tightly regulated control of many important...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (21): 3633–3642.
Published: 1 November 2010
...@weigelworld.org ) * Present address: Scuola Superiore Sant'Anna, 56127 Pisa, Italy Competing interests statement 30 8 2010 © 2010. MicroRNA miRNA miR172 APETALA2 AGAMOUS ABC model Homeotic genes Arabidopsis Flower formation in plants requires...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2951–2960.
Published: 1 September 2010
... expression is post-transcriptionally regulated by two microRNAs (miRNAs), miR-iab4 and miR-iab8, acting on target sites located in the 3′ untranslated regions (UTRs) of Ubx mRNAs. Here, we show that during embryonic development Ubx produces mRNAs with variable 3′UTRs in different regions of the embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (13): 2127–2132.
Published: 1 July 2010
...Holger Budde; Sebastian Schmitt; Dirk Fitzner; Lennart Opitz; Gabriela Salinas-Riester; Mikael Simons The generation of myelinating cells in the central nervous system requires the initiation of specific gene expression programs in oligodendrocytes. We reasoned that microRNAs (miRNAs) could play...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (24): 3989–3993.
Published: 15 December 2008
... by derepression of the p85β subunit of PI3 kinase and of Spred1,respectively. These studies demonstrate the regulation of angiogenesis by an endothelial miRNA, attribute previously described Egfl7 vascular phenotypes to miR-126 , and document inadvertent miRNA dysregulation as a complication of mouse knockout...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4265–4272.
Published: 1 December 2007
... of GSCs, we show that AGO1 is not required for bag of marbles ( bam ) silencing and probably acts downstream or parallel of bam in the regulation of GSC fate. Given that AGO1 serves as a key component of the miRNA pathway, we propose that an AGO1-dependent miRNA pathway probably plays an instructive role...
Includes: Supplementary data