... tissue-specific transcription mesoderm-inducing factors retinoic acid pronephros Xenopus endoderm animal cap HNF4 activin A Specification of the body plan during early embryogenesis is dependent on the cooperation of inductive interactions and transcriptional hierarchies. Induction...

... overlying equatorial cells. Recently, a number of ‘mesoderm-inducing factors’ (MIFs), which may be responsible for this interaction, have been discovered. Examples of these MIFs include members of the fibroblast growth factor family as well as members of the TGF- β superfamily such as TGF- β 2. In addition...

... of the equatorial zone. A small amount of maternal xsna is localised in the vegetal hemisphere before zygotic transcription starts. xsna is not present in isolated animal caps but can be induced by the mesoderm-inducing factors XTC-MIF and bFGF. Synthesis of xsna does not occur autonomously in dispersed cells...

...J. C. Smith; K. Symes; R. O. Hynes; D. DeSimone Exposure of isolated Xenopus animal pole ectoderm to the XTC mesoderm-inducing factor (XTC-MIF) causes the tissue to undergo gastrulation-like movements. In this paper, we take advantage of this observation to investigate the control of various...

... . 10.1016/S0012-1606(89)80012-0 Cooke , J. , Smith , J. C. , Smith , E. J. and Yaqoob , M. ( 1987 ). The organization of mesodermal pattern in Xenopus laevis : experiments using a Xenopus mesoderm-inducing factor . Development 101 , 893 – 908 . 10.1242/dev.101.4.893...

... frog development. Recent work is overcoming these problems, but acceptance of the new mesoderm-inducing factors has been facilitated by the fact that they are related to known peptide growth factors. One class of MIFs is related to transforming growth factor type β (TGF-β ). This group...

... by Company of Biologists 1989 Xenopus laevis mesoderm induction mesoderm-inducing factors fibroblast growth factor fibroblast growth factor receptor transforming growth factor beta competence morphogens Work in experimental embryology has given us a fairly detailed picture...

... by the factors. * Present address: Department of Zoology, University of California, Berkeley, CA 94720, USA Copyright © 1989 by Company of Biologists 1989 mesoderm induction mesoderm-inducing factors bFGF XTC-MIF thresholds gastrulation amphibian embryo Xenopus laevis developmental...

... XTC cell line secretes a factor which has the properties we would expect of a mesoderm-inducing factor. In this paper, we show that an early response to this factor by isolated Xenopus animal pole regions is a change in shape, involving elongation and constriction. We show by several criteria...