... fertilization, maternally deposited mRNAs direct biological processes to the point of zygotic genome activation (ZGA). These maternal mRNAs undergo cytoplasmic polyadenylation (CPA), suggesting translational control of their activation. To elucidate the biological role of CPA during embryogenesis, we performed...

... of dorsal-anterior structures and overexpressed organizer-specific genes, indicating that maternal Bicc1 is crucial for normal embryonic patterning of the vertebrate embryo. Bicc1 is an RNA-binding protein with robust translational repression function. Here, we show that the maternal mRNA encoding the cell...

...Douglas W. Houston; Christopher Wylie During the development of Xenopus laevis , maternal mRNAs and proteins stored in the egg direct early patterning events such as the specification of the dorsoventral axis and primary germ layers. In an expression screen to identify maternal factors important...

... ). * Author for correspondence (e-mail: lgavis@molbio.princeton.edu ) 21 9 2004 © 2004. 2004 nanos Translational control Translational regulation Translational repressor Drosophila Oogenesis Embryogenesis Maternal mRNA Control of mRNA translation plays an important role...

...Christian Sardet; Hiroki Nishida; François Prodon; Kaichiro Sawada Localization of maternal mRNAs in the egg cortex is an essential feature of polarity in embryos of Drosophila , Xenopus and ascidians. In ascidians, maternal mRNAs such as macho 1 , a determinant of primary muscle-cell fate, belong...

... in translational regulation. These factors should constitute a network; therefore, the identification and characterization of other regulators and target mRNAs is needed to understand the nature of the translational control of maternal mRNA. We thank R. Barstead for the two-hybrid cDNA library, J. Kimble...

..., Japan ‡ Present address: Oregon Regional Primate Research Center, Oregon Health Sciences University, 505 N.W. 185th Avenue, Beaverton, OR 97006, USA 07 12 2000 07 02 2001 © 2001 by Company of Biologists 2001 Oocyte-specific linker histone Mouse Oocyte Maternal mRNA...

... provides a suitable and robust approach to study the function of dormant maternal mRNAs. Mos (originally known as c- mos ) and tissue plasminogen activator (tPA, Plat ) mRNAs are dormant maternal mRNAs that are recruited during oocyte maturation; translation of Mos mRNA results in the activation of MAP...

... maternal mRNA ( Kim-Ha et al., 1995 ). Premature translation of oskar mRNA in the oocyte leads to lethality of the embryo. In Xenopus , polyadenylation has been extensively studied in both oogenesis and embryogenesis. An RNA with homology to nos, Xcat-2 , is localized to the vegetal pole...

...Joan E. Wilson; Joanne E. Connell; Paul M. Macdonald ABSTRACT Although translational regulation of maternal mRNA is important for proper development of the Drosophila embryo, few genes involved in this process have been identified. In this report, we describe the role of aubergine in oskar...

... remain sufficiently active to degrade injected mRNA some time after their (the oligos’) introduction. One reassuring outcome of these experiments is that oligos targetted on different maternal mRNAs cause different phenotypes in development. Preliminary results suggest that vimentin mRNA...

...Joel K. Yisraeli; Sergei Sokol; D. A. Melton In an effort to understand how polarity is established in Xenopus oocytes, we have analyzed the process of localization of the maternal mRNA, vg1. In fully grown oocytes, vg1 mRNA is tightly localized at the vegetal cortex. Biochemical fractionation...

... 1986 by Company of Biologists 1986 ascidian embryo maternal mRNA proteins determinant alkaline phosphatase actin nucleus Styela plicata . This paper reviews the class of cytoplasmic determinants that function independently of embryonic gene expression in ascidian embryos...