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Gene expression patterns in the anterior part of PSM.  (A-A″) Double color ...
Published: 4 March 2024
Fig. 1. Gene expression patterns in the anterior part of PSM. (A-A″) Double color in situ hybridization of Uncx4 (orange) and Sall4 (purple) at E10.5 ( n =3). The Sall4 detection reaction was stopped early to visualize a strong expression domain. A and A″ show dorsal views; A′ shows a la... More about this image found in Gene expression patterns in the anterior part of PSM. (A-A″) Double color ...
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Gene expression patterns in the PSM.  (A-J′) Expression patterns of  Tbx6  ...
Published: 4 March 2024
Fig. 2. Gene expression patterns in the PSM. (A-J′) Expression patterns of Tbx6 [A ( n =6), A′ ( n =5), F ( n =6), F′ ( n =6)], Dll1 [B ( n =6), B′ ( n =3), G ( n =6), G′ ( n =4)], Notch1 [C ( n =6), C′ ( n =3), H ( n =6), H′ ( n =6)], Lef1 [D ( n =4), D′( n =3), I ( n =4), I′ ( n =3)], ... More about this image found in Gene expression patterns in the PSM. (A-J′) Expression patterns of Tbx6 ...
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Gene expression patterns in the  somites.  (A-L′) Expression patterns of  U...
Published: 4 March 2024
Fig. 3. Gene expression patterns in the somites. (A-L′) Expression patterns of Uncx4 [A ( n =6), A′ ( n =3), G ( n =6), G′ ( n =4)], Tcf15 [B ( n =6), B′ ( n =5), H ( n =6), H′ ( n =4)], Meox1 [C ( n =4), C′ ( n =4), I ( n =4), I′ ( n =3)], Aldh1a2 [D ( n =4), D′ ( n =3), J ( n =4), J′ ... More about this image found in Gene expression patterns in the somites. (A-L′) Expression patterns of U...
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Chromatin accessibility of mesoderm-enriched tissue from the posterior trun...
Published: 4 March 2024
Fig. 4. Chromatin accessibility of mesoderm-enriched tissue from the posterior trunk. (A) Heatmap showing genome-wide accessibility in Sall4 cHet and Sall4 cKO samples, and SALL4 enrichment in the same genomic intervals. The x -axis corresponds to ±100 base pairs from the center of accessib... More about this image found in Chromatin accessibility of mesoderm-enriched tissue from the posterior trun...
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WNT regulators with differential accessibility and differential expression ...
Published: 4 March 2024
Fig. 5. WNT regulators with differential accessibility and differential expression between Sall4 cHet and Sall4 cKO. (A) Heatmap and bar chart showing differential accessibility and expression of genes involved in activating WNT signaling. Gray shading indicates FDR. (B) Heatmap and bar char... More about this image found in WNT regulators with differential accessibility and differential expression ...
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Sall4  represses neural gene expression in mesoderm through regulation of c...
Published: 4 March 2024
Fig. 6. Sall4 represses neural gene expression in mesoderm through regulation of chromatin accessibility. (A) Heatmap and bar chart showing differential accessibility and expression of genes related to neural differentiation. (B) Volcano plot of footprinting of differential accessible regions.... More about this image found in Sall4 represses neural gene expression in mesoderm through regulation of c...
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Models for  Sall4  functions in PM development.  (A)  Sall4  contributes to...
Published: 4 March 2024
Fig. 7. Models for Sall4 functions in PM development. (A) Sall4 contributes to multiple aspects of PSM development and somite development. (B) Sall4 -dependent open chromatin status drives repression and activation of negative regulators and positive regulators, respectively, of WNT signali... More about this image found in Models for Sall4 functions in PM development. (A) Sall4 contributes to...
Journal Articles
In collection:
Neural development
Journal: Development
Development (2024) 151 (5): dev202545.
Published: 4 March 2024
... modification that is essential for signaling but complicates their biochemical purification and in vitro application ( Janda et al., 2012 ). However, GSK3α/β kinases are pleiotropic kinase also involved in FGF, Hedgehog, Notch, insulin and mTOR signaling, which are pathways known to be implicated in neural...
Includes: Supplementary data
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FZD5 cell surface expression is uniquely upregulated in anterior neural pro...
Published: 4 March 2024
Fig. 1. FZD5 cell surface expression is uniquely upregulated in anterior neural progenitors. (A) Schematic outlining the derivation of regional neural progenitors from hPSCs and antibody-based profiling of surface expression of FZD receptor. (B) The percentages of expression of each FZD in H1 hE... More about this image found in FZD5 cell surface expression is uniquely upregulated in anterior neural pro...
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A genome-wide CRISPR screen identifies regulators of FZD5 expression during...
Published: 4 March 2024
Fig. 2. A genome-wide CRISPR screen identifies regulators of FZD5 expression during neural induction. (A) Volcano plot depicting the gene level summary of gRNAs that regulate FZD5 surface expression identified in the CRISPR screen. Red dots represent regulators with FDR<0.1. The bottom panel ... More about this image found in A genome-wide CRISPR screen identifies regulators of FZD5 expression during...
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F5L6.13 activates Wnt signaling to pattern VM progenitors from hPSCs.  (A) ...
Published: 4 March 2024
Fig. 3. F5L6.13 activates Wnt signaling to pattern VM progenitors from hPSCs. (A) Schematic of VM progenitor differentiation protocol from hPSCs. (B) qPCR gene marker expression of LMX1A , FOXA2 and OTX2 in day 16 differentiated cells patterned with CHIR99021 or F5L6.13, and H1 ESCs (ES). D... More about this image found in F5L6.13 activates Wnt signaling to pattern VM progenitors from hPSCs. (A) ...
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F5L6.13-patterned VM progenitors give rise to DA neurons  in vitro  and res...
Published: 4 March 2024
Fig. 4. F5L6.13-patterned VM progenitors give rise to DA neurons in vitro and rescue the motor dysfunction in the 6-OHDA rat model in vivo . (A) Immunostaining for TH, MAP2 and FOXA2 in day 45 differentiated neuronal cultures from VM progenitors patterned with CHIR99021 or F5L6.13 in H1 hESCs... More about this image found in F5L6.13-patterned VM progenitors give rise to DA neurons in vitro and res...
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scRNA sequencing of day 11 VM progenitors patterned by F5L6.13 and CHIR9902...
Published: 4 March 2024
Fig. 5. scRNA sequencing of day 11 VM progenitors patterned by F5L6.13 and CHIR99021. (A) Schematic of the workflow in 10x Cellplex pipeline labelling the differentiated cells with CMOS for barcoding before sample processing and sequencing. This experiment was performed using one biological repl... More about this image found in scRNA sequencing of day 11 VM progenitors patterned by F5L6.13 and CHIR9902...
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scRNA sequencing of day 30 VM neuronal population patterned by F5L6.13 and ...
Published: 4 March 2024
Fig. 6. scRNA sequencing of day 30 VM neuronal population patterned by F5L6.13 and CHIR99021. (A) UMAP plot showing clustering of the day 30 single cells from one biological replicate. (B) UMAP plot showing the cell identity of treatment conditions (CHIR99021 or F5L6.13) contributing the cluster... More about this image found in scRNA sequencing of day 30 VM neuronal population patterned by F5L6.13 and ...