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Features of immature and mature cardiomyocytes  in vivo.   Cardiomyocyte ma...
Published: 1 June 2023
Fig. 1. Features of immature and mature cardiomyocytes in vivo. Cardiomyocyte maturation from the fetal (top left) to the adult (top right) heart, including morphological, ultrastructural, transcriptional and metabolic changes. Fetal cardiomyocytes are round and mononucleated, while adult card... More about this image found in Features of immature and mature cardiomyocytes in vivo. Cardiomyocyte ma...
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Methods for maturing hPSC-CMs  in vitro.   Several aspects can be considere...
Published: 1 June 2023
Fig. 2. Methods for maturing hPSC-CMs in vitro. Several aspects can be considered to tackle the intrinsic immaturity of cultured cardiomyocytes in vitro and induce their maturation. (A) The extracellular matrix (ECM) is a key component in cardiomyocyte maturation that can be manipulated, tog... More about this image found in Methods for maturing hPSC-CMs in vitro. Several aspects can be considere...
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Major technical challenges of studying early human development.  Some of th...
Published: 1 June 2023
Fig. 1. Major technical challenges of studying early human development. Some of the challenges facing researchers include the broad categories of access to research materials, which includes both accessing clinical samples directly (upper left) and extant collections of embryonic and fetal mater... More about this image found in Major technical challenges of studying early human development. Some of th...
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Groucho is primarily phosphorylated in pH3-positive mitotic cells.  (A,A′) ...
Published: 1 June 2023
Fig. 1. Groucho is primarily phosphorylated in pH3-positive mitotic cells. (A,A′) Quantification of the percentage of area (semi-automated; A) and the proportion of nuclei (manually scored; A′), co-stained (black) or not (grey) for both pGro and Gro in wing and eye imaginal discs ( Fig. S1 ). (A... More about this image found in Groucho is primarily phosphorylated in pH3-positive mitotic cells. (A,A′) ...
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Groucho is phosphorylated during G1 , G2 and M phases.  (A) Schematic repre...
Published: 1 June 2023
Fig. 2. Groucho is phosphorylated during G1 , G2 and M phases. (A) Schematic representation of the central part of the wing imaginal disc (area boxed in B-G) (adapted from Zielke et al., 2014 ). In this region, a stripe of anterior cells that are arrested at the G1 phase (grey) are flanked by c... More about this image found in Groucho is phosphorylated during G1 , G2 and M phases. (A) Schematic repre...
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Groucho is unphosphorylated during S phase.  (A-C) Confocal image of a  PCN...
Published: 1 June 2023
Fig. 3. Groucho is unphosphorylated during S phase. (A-C) Confocal image of a PCNA-GFP third instar wandering larval wing imaginal disc, stained for pGro (red; A,C). Cells in S phase are GFP-positive (green; B,C). (D-I) Confocal images of third instar wild-type wandering larval wing (D-F) and ... More about this image found in Groucho is unphosphorylated during S phase. (A-C) Confocal image of a PCN...
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Ectopic expression of Groucho reduces the number of pH3-positive cells.  (A...
Published: 1 June 2023
Fig. 4. Ectopic expression of Groucho reduces the number of pH3-positive cells. (A-J′) Confocal images of wing imaginal discs (A-H) and stage 11 embryo (lateral view; I-J′), ectopically expressing non-phosphorylatable Gro (Gro AA ; A,B), phosphomimetic Gro (Gro DD ; C,D) or native Gro (E,F,I-J′)... More about this image found in Ectopic expression of Groucho reduces the number of pH3-positive cells. (A...
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Cells accumulate at G2 phase upon ectopic expression of Groucho.  (A) An ac...
Published: 1 June 2023
Fig. 5. Cells accumulate at G2 phase upon ectopic expression of Groucho. (A) An activated Cdk1/CycB complex phosphorylates GST-tagged, full-length Gro in vitro . Three independent kinase assays resulted in similar outcomes. (B-F) Cdk1 phosphorylates Groucho in vivo . (B-E) Confocal images of t... More about this image found in Cells accumulate at G2 phase upon ectopic expression of Groucho. (A) An ac...
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Groucho represses  e2f1  expression.  (A) Gro binds in shared clusters with...
Published: 1 June 2023
Fig. 6. Groucho represses e2f1 expression. (A) Gro binds in shared clusters within (boxed) and downstream of the e2f1 gene locus in three Drosophila cell lines, derived from different origins. Panel shows Genome Browser view of ChIP-seq data analyses depicting the profiles of Gro binding i... More about this image found in Groucho represses e2f1 expression. (A) Gro binds in shared clusters with...
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Cells devoid of  groucho  undergo accelerated cell cycles and accumulate at...
Published: 1 June 2023
Fig. 7. Cells devoid of groucho undergo accelerated cell cycles and accumulate at G1 phase. (A,A′) Confocal images of third instar wandering larval eye imaginal disc, stained for E2F1 (blue) and EdU (red). gro clones are detectable by lack of GFP staining and by adjacent GFP-positive twin sp... More about this image found in Cells devoid of groucho undergo accelerated cell cycles and accumulate at...
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Cell type differentiation as a dynamical process.  (A) Reimagination of Wad...
Published: 1 June 2023
Fig. 1. Cell type differentiation as a dynamical process. (A) Reimagination of Waddington's landscape of cell fate commitment in which cell fates are represented as valleys, commitment barriers as hills and gene activity as pegs underneath that control the heights of hills and valleys. (B) Schem... More about this image found in Cell type differentiation as a dynamical process. (A) Reimagination of Wad...
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Analysis of a gene regulatory network around a saddle-node bifurcation.  (A...
Published: 1 June 2023
Fig. 2. Analysis of a gene regulatory network around a saddle-node bifurcation. (A) Schematic of the GRN for 5 of the 102 genes. Undisplayed nodes have a unidirectional arrow stemming from either g 1 or g 2 . (B) Distributions of g 1 at steady state (see Materials and Methods section ‘Si... More about this image found in Analysis of a gene regulatory network around a saddle-node bifurcation. (A...
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Analysis of a gene regulatory network around a saddle-node bifurcation.  (A...
Published: 1 June 2023
Fig. 2. Analysis of a gene regulatory network around a saddle-node bifurcation. (A) Schematic of the GRN for 5 of the 102 genes. Undisplayed nodes have a unidirectional arrow stemming from either g 1 or g 2 . (B) Distributions of g 1 at steady state (see Materials and Methods section ‘Si... More about this image found in Analysis of a gene regulatory network around a saddle-node bifurcation. (A...