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Keywords: let-7
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Journal Articles
Journal: Development
Development (2018) 145 (15): dev162594.
Published: 2 August 2018
... evidence that Erk signaling during synovial joint development determines articular cartilage thickness in adult mice. Articular cartilage Kras Erk let-7 Lin28 MicroRNA Osteoarthritis Osteoarthritis (OA) is a highly prevalent skeletal condition among the elderly ( Dieppe and Lohmander...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (5): 976–986.
Published: 1 March 2013
... germ layer specification, and that this early function is probably independent of the recognised role of Lin28 proteins in negatively regulating let-7 miRNA biogenesis. Total RNA was isolated using miRVana miRNA Isolation Kit (Applied Biosystems). cDNA was synthesized with miRNA-specific primers...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (10): 1788–1797.
Published: 15 May 2012
... of the evolutionarily conserved let-7-complex ( let-7-C ) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125. These small RNAs post-transcriptionally regulate the expression of target genes, and are required for the remodeling of the Drosophila neuromusculature during the larval-to-adult...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (23): 4631–4641.
Published: 1 December 2006
...Gabriel D. Hayes; Alison R. Frand; Gary Ruvkun The let-7 microRNA (miRNA) gene of Caenorhabditis elegans controls the timing of developmental events. let-7 is conserved throughout bilaterian phylogeny and has multiple paralogs. Here, we show that the paralog mir-84 acts synergistically with let-7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (9): 2049–2059.
Published: 1 May 2004
... and execution of stage-specific developmental events at two stages: the third larval stage and adult. We also show that lin-46 is required prior to the third stage for normal adult cell fates, suggesting that it acts once to control fates at both stages, and that it affects adult fates through the let-7 branch...