... cartilage volume is poorly understood. Here, we provide evidence that Erk signaling during synovial joint development determines articular cartilage thickness in adult mice. Articular cartilage Kras Erk let-7 Lin28 MicroRNA Osteoarthritis Osteoarthritis (OA) is a highly prevalent...

... germ layer specification, and that this early function is probably independent of the recognised role of Lin28 proteins in negatively regulating let-7 miRNA biogenesis. * Author for correspondence ( harry.isaacs@york.ac.uk ) Competing interests statement The authors declare no competing...

... of the evolutionarily conserved let-7-complex ( let-7-C ) locus, which encodes the co-transcribed microRNAs miR-100, let-7 and miR-125. These small RNAs post-transcriptionally regulate the expression of target genes, and are required for the remodeling of the Drosophila neuromusculature during the larval-to-adult...

...Gabriel D. Hayes; Alison R. Frand; Gary Ruvkun The let-7 microRNA (miRNA) gene of Caenorhabditis elegans controls the timing of developmental events. let-7 is conserved throughout bilaterian phylogeny and has multiple paralogs. Here, we show that the paralog mir-84 acts synergistically with let-7...

... and execution of stage-specific developmental events at two stages: the third larval stage and adult. We also show that lin-46 is required prior to the third stage for normal adult cell fates, suggesting that it acts once to control fates at both stages, and that it affects adult fates through the let-7 branch...