...Otto J. M. Mäkelä; Marja L. Mikkola ABSTRACT Tissue interactions are essential for guiding organ development and regeneration. Hair follicle formation relies on inductive signalling between two tissues, the embryonic surface epithelium and the adjacent mesenchyme. Although previous research has...

... that inform cell fates within a tissue. It has been proposed that bioelectric signaling through Vmem could also serve as such a gradient through the electro-coupling of cells ( Adams and Levin, 2013 ). Induction refers to the process of transmitting a signal to a receiving cell or tissue to cause...

...Tara M. Fresques; Gary M. Wessel ABSTRACT Specification of the germ cell lineage is required for sexual reproduction in animals. The mechanism of germ cell specification varies among animals but roughly clusters into either inherited or inductive mechanisms. The inductive mechanism, the use of cell...

... sexual dimorphism, bud induction, branching morphogenesis and cellular differentiation. * Author for correspondence ( mshen@columbia.edu ) Competing interests The authors declare no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017 Summary...

..., in the lateral trunk mesoderm, ventral neuroepithelium, at the midbrain-hindbrain boundary, and in sensory organs ( Fig. 2 )( Sandell et al., 2007 ; Cammas et al., 2007 ; Romand et al., 2008 ). However,there are differences in the timing of induction and distribution of gene transcripts in both species...

... commitment just prior to morphological differentiation. * Author for correspondence (e-mail: mbronner@caltech.edu ) 17 10 2008 © 2008. 2008 Olfactory placode Nasal placode Chick Competence Specification Commitment Induction Ectoderm Cranial sensory placodes arise...

...Chang-Soo Hong; Byung-Yong Park; Jean-Pierre Saint-Jeannet Two independent signals are necessary for neural crest (NC) induction in Xenopus : a Bmp signal, which must be partially attenuated by Bmp antagonists, and a separate signal mediated by either a canonical Wnt or an Fgf. The mesoderm...

... interactions between the neural tube and adjacent ectoderm. This induction triggers expression of Pax3, ingression of placode cells and their differentiation into neurons. However, the molecular nature of the underlying signals remains unknown. Here, we investigate the role of PDGF signaling in ophthalmic...

... FoxE3 expression posteriorly. These data provide the first direct evidence of the involvement of Notch signaling in lens induction. The obligate integration of inputs of a field-selector (Otx2)and localized signaling (Notch) within target cis-regulatory elements might be a general mechanism of organ...

... Wnt FGF Erk Signaling Lens Induction Mouse Multiple signaling pathways are involved in early-lens morphogenesis,including bone morphogenic proteins (BMPs), fibroblast growth factors (FGFs),Wnts and hedgehog (Hh). Genetic inactivation of Bmp4 or Bmp7 in mice abolished Sox2 expression...

... and Sox10 expression domains. Although morpholino-mediated knockdown of Sox8 protein did not prevent the formation of neural crest progenitors, the timing of their induction was severely affected. This delay in neural crest specification had dramatic consequences on the development of multiple lineages...

... colliculus, or optic tectum, is that axons carrying similar amounts of Eph receptor terminate near to one another on the target structure. I show how the previously proposed marker induction model embodies this principle and predicts these results. I then describe a new version of the model in which...

... signaling. This suggests a two-step model of craniofacial placode induction in which ectoderm first acquires pre-placodal region identity, and subsequently differentiates into particular craniofacial placodes under the influence of local inducing signals. © 2006. 2006 Inner ear Otic placode...

... induction ( Harrison,1936 ). In chicken, the AP axis appears to be specified later in development ( Wu et al., 1998 ). Nevertheless, results from both species indicate that the AP axis is specified before the DV axis, suggesting that axial specification occurs in multiple stages ( Harrison, 1936 ; Wu et al...

... are essential for mesodermal induction, and that these factors are expressed in ABa, but not ABp, descendants. We provide evidence that the first Notch interaction functions largely, if not entirely, to prevent TBX-37, TBX-38 expression in ABp descendants. Neither the second Notch interaction nor TBX-37, TBX-38...

... identified as a localized muscle determinant, is also required for mesenchyme induction, and that it plays a role in making the cell response differ between notochord and mesenchyme induction. A zygotic event involving snail expression downstream of maternal macho-1 mediates the suppression of notochord...

...Susan C. Chapman; Frank R. Schubert; Gary C. Schoenwolf; Andrew Lumsden Previous studies of head induction in the chick have failed to demonstrate a clear role for the hypoblast and anterior definitive endoderm (ADE) in patterning the overlying ectoderm, whereas data from both mouse and rabbit...

... arising from the underlying mesoderm and adjacent neurectoderm. In mice, Fgf3 is expressed in the neurectoderm prior to and concomitant with placode induction and otic vesicle formation,but its absence affects only the later stages of otic vesicle morphogenesis. We show here that mouse Fgf10 is expressed...

... of these may act as composite mechanisms in two different ways. The simple categories are cell autonomous mechanisms in which cells enter into specific arrangements (`patterns') without interacting, inductive mechanisms in which cell communication leads to changes in pattern by reciprocal or hierarchical...

... the identities and temporal expression patterns of genes up-regulated 24 hours after neural crest induction, coupled with the knowledge that not all cells in the neural folds will become migratory( Bronner-Fraser and Fraser,1988 ; Selleck and Bronner-Fraser, 1995 ), we hypothesize a sequential activation...