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Keywords: homothorax
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Journal Articles
Journal: Development
Development (2015) 142 (8): 1470–1479.
Published: 15 April 2015
..., Yorkie forms complexes with several tissue-specific DNA-binding partners, which help to define the tissue-specific target genes of Yorkie. In the progenitor cells of the eye imaginal disc, the DNA-binding transcription factor Homothorax is required for Yorkie-promoted proliferation and survival through...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (14): 2838–2847.
Published: 15 July 2014
... on Hedgehog (Hh) signaling, which is delivered by the incoming photoreceptor axons, and occurs in a wave-like fashion. Despite the primary role of lamina neurons in visual perception, it is still unclear how these neurons are specified from neuroepithelial (NE) progenitors. Here we show that a homothorax...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (2): 273–281.
Published: 15 January 2010
... acts independently of the transcription factor Homothorax, which was previously shown to promote head cuticle development in the same region. Chip and its vertebrate CLIM homologues have been shown to form complexes with LIM-homeodomain transcription factors, and the domain of Chip that mediates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (22): 5011–5020.
Published: 15 November 2005
... specification genes by the wingless ( wg ) and decapentaplegic ( dpp ) signaling pathways. Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient. References Azpiazu, N. and Morata, G. ( 2000 ). Function and regulation of homothorax in the wing...
Journal Articles
Journal: Development
Development (2004) 131 (22): 5683–5693.
Published: 15 November 2004
... and level of these signals and other factors present at the time of signal transduction. Two such factors, teashirt ( tsh ) and homothorax ( hth ), are initially co-expressed throughout the entire wing disc, but are later repressed in distal cells, permitting the subsequent elaboration of distal fates...
Journal Articles
Journal: Development
Development (2004) 131 (4): 767–774.
Published: 15 February 2004
..., Spain 28 10 2003 © 2004. 2004 Homothorax Distal-less Nubbin Limb development Imaginal disc The progenitors of the adult body regions in Drosophila are set aside in the embryonic ectoderm as discrete groups of cells known as imaginal discs. The disc primordia contain...
Journal Articles
Journal: Development
Development (2003) 130 (6): 1171–1180.
Published: 15 March 2003
... to differentiation of antenna-specific characteristics. Antenna-specific expression of dan and danr depends on a regulatory hierarchy involving homothorax and Distal-less , as well as cut and spineless . We propose that dan and danr are effector genes that act downstream of these genes to control differentiation...
Journal Articles
Journal: Development
Development (2002) 129 (19): 4371–4386.
Published: 1 October 2002
... and limb development. Differentiation 49 , 93 -99. Dong, P. D. S., Chu, J. and Panganiban, G. ( 2000 ). Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity. Development 127 , 209 -216. Dong, P. D. S., Chu, J. and Panganiban, G...
Journal Articles
Journal: Development
Development (2002) 129 (10): 2411–2418.
Published: 15 May 2002
... territory and by repression of the homeodomain protein Homothorax. We report that repression of the zinc-finger transcription factor Teashirt (Tsh) is the earliest event in wing specification. Repression of Tsh by the combined action of Wingless and Decapentaplegic is required for wing pouch formation...
Journal Articles
Journal: Development
Development (2002) 129 (8): 1967–1974.
Published: 15 April 2002
... for antenna development. The nuclear factors, Homothorax, Distal-less and Spineless, are each required for particular aspects of antennal fate. Coexpression of Homothorax, necessary for nuclear localization of its ubiquitously expressed partner Extradenticle, with Distal-less is required to establish antenna...
Journal Articles
Journal: Development
Development (2002) 129 (3): 695–704.
Published: 1 February 2002
...-specifying gene, homothorax , in conjunction with dachshund and spalt , and there is much less overlap between the bric a brac and the dachshund domains. Thus tissue-specific expression of other patterning genes that differentially repress bric a brac accounts for antenna-leg differences in bric a brac...
Journal Articles
Journal: Development
Development (2001) 128 (22): 4511–4521.
Published: 15 November 2001
... arise. I further demonstrate that the proximal-distal patterning genes homothorax and dachshund are positively required, while Distal-less is unexpectedly negatively required, to establish the segmental pattern of Notch ligand and fringe expression. Two Serrate enhancers that respond to regulation...
Journal Articles
Journal: Development
Development (2001) 128 (18): 3405–3413.
Published: 15 September 2001
...Adi Inbal; Naomi Halachmi; Charna Dibner; Dale Frank; Adi Salzberg Homothorax (HTH) is a homeobox-containing protein, which plays multiple roles in the development of the embryo and the adult fly. HTH binds to the homeotic cofactor Extradenticle (EXD) and translocates it to the nucleus. Its...
Journal Articles
Journal: Development
Development (2001) 128 (12): 2365–2372.
Published: 15 June 2001
..., R. (1935) Book Principles of Insect Morphology . New York: McGraw-Hill). To gain insight into how variations between the antenna and the leg may have arisen, we have compared the epistatic relationships among three major proximodistal patterning genes, Distal-less , dachshund and homothorax...
Journal Articles
Journal: Development
Development (2000) 127 (12): 2685–2693.
Published: 15 June 2000
...Natalia Azpiazu; Ginés Morata ABSTRACT The gene homothorax (hth) is originally expressed uniformly in the wing imaginai disc but, during development, its activity is restricted to the cells that form the thorax and the hinge, where the wing blade attaches to the thorax, and eliminated in the wing...
Journal Articles
Journal: Development
Development (2000) 127 (7): 1499–1508.
Published: 1 April 2000
... target genes are activated by wg to generate hinge structures. Here we show that wg activates the gene homothorax ( hth ) in the hinge and that hth is necessary for hinge development. Further, we demonstrate that hth also limits where along the D/V compartment boundary wing blade development can initiate...
Journal Articles
Journal: Development
Development (2000) 127 (2): 209–216.
Published: 15 January 2000
...-specifying activity of Distal-less is genetically separable from the proximodistal patterning function in that certain Distal-less allelic combinations exhibit antenna-to-leg transformations without proximodistal truncations. Here, we show that Distal-less acts in parallel with homothorax , a previously...
Journal Articles
Journal: Development
Development (1999) 126 (22): 5137–5148.
Published: 15 November 1999
... localization requires a third homeodomain protein, Homothorax (HTH). Here we show that a conserved N-terminal domain of HTH directly binds to EXD in vitro, and is sufficient to induce the nuclear localization of EXD in vivo. However, mutating a key DNA binding residue in the HTH homeodomain abolishes many...
Journal Articles
Journal: Development
Development (1999) 126 (15): 3407–3413.
Published: 1 August 1999
...Satoshi Goto; Shigeo Hayashi Proximodistal patterning in the Drosophila leg is elaborated from the circular arrangement of the proximal domain expressing escargot and homothorax , and the distal domain expressing Distal-less that are allocated during embryogenesis. The distal domain differentiates...
Journal Articles