... development are closely related during embryogenesis. Both cell types primarily arise from the lateral plate mesoderm (LPM) and share a common progenitor ( Qian et al., 2005 ; Reischauer et al., 2016 ; Stainier et al., 1995 ; Thompson et al., 1998 ). Additionally, during definitive hematopoiesis, some HSCs...

...Xue Zhang; Yuxi Yang; Yuxuan Wei; Qingshun Zhao; Xin Lou ABSTRACT Hematopoiesis is a highly coordinated process that generates all the body's blood cells, and perturbations in embryonic hematopoiesis may result in illnesses ranging from fetal anemia to various leukemias. Correct establishment...

... in spi2 mutants ( Fig. 4 G), suggesting that Spi2 works together with other Runx1 downstream factor(s) to regulate HSPC expansion in the CHT. In conclusion, our study identified a previously uncharacterized ETS factor Spi2 in zebrafish and revealed its essential role in definitive hematopoiesis...

... liver for expansion and maturation before finally colonizing the bone marrow and sustaining adult hematopoiesis ( Kieusseian et al., 2012 ). To fulfill the intense demand of short-lived mature blood cells to support the normal function of different organs, HSPCs need to be highly active to replenish...

... as important determinants of organ homeostasis, tissue repair, remodeling and regeneration. Although the ontogeny and function of tissue-resident macrophages has been identified as distinct from postnatal hematopoiesis, the inability to specify, in vitro , similar populations that recapitulate...

...Donn A. Van Deren; Shrutokirti De; Ben Xu; Kayla M. Eschenbacher; Shuhua Zhang; Mario R. Capecchi ABSTRACT Previously, we have demonstrated that a subpopulation of microglia, known as Hoxb8 microglia, is derived from the Hoxb8 lineage during the second wave (E8.5) of yolk sac hematopoiesis, whereas...

... cells develop via IL7Rα-positive progenitors and are repopulated by transplanted adult hematopoietic stem cells; however, such TLC lymphopoiesis cannot be fully rescued in IL7Rα −/− recipient mice. Hematopoiesis IL7R Lineage tracing Hematopoietic stem cells Transplantation Tissue-resident...

... fate decisions. To further interrogate definitive hematopoiesis in the CHT of vegfc loss-of-function embryos, we examined expression of the cmyb marker using WISH. Interestingly, in contrast to the decrease of cd41:gfp+ cells we observed in the CHT of vegfc crispant ( Fig. 2 A,B...

... to be a crucial and under-appreciated determinant of cell-fate decision-making during hematopoiesis. Cell fate Hematopoiesis Mathematical modeling Gene regulatory network Bistability University of Southern California http://dx.doi.org/10.13039/100006034 National Science Foundation...

... blood cell types in Drosophila and act as signaling centers to neighboring cells. Drosophila Intermediate progenitor Blood cell development Crystal cells Hematopoiesis Split GAL4 National Institutes of Health R01 HL-067395 R01 CA-217608 T32HL863458 K12GM106996 T32HL69766...

... The authors declare no competing or financial interests. 24 9 2020 12 3 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: This study investigates the process of early T cell development, and how adult hematopoiesis is regulated by distinct mechanisms...

... microglial waves, we uncover non-overlapping roles for csf1ra and csf1rb in hematopoiesis, and identified csf1rb as an essential regulator of adult microglia development. Notably, we demonstrate that csf1rb positively regulates HSC-derived myelopoiesis, resulting in macrophage deficiency, including microglia...

... taxa. Here, we demonstrate novel PSEDN roles in vivo in Drosophila hematopoiesis and in human erythropoiesis in vitro . Using Drosophila genetics, we show that PSEDN members function with GATA to block lamellocyte differentiation and maintain the prohemocyte pool. Overexpression of human SIX1...

..., Runx2 mice display neonatal lethality, and Runx3 knockouts have mixed survival rates depending on the model and strain used. These models initially revealed that RUNX1 is essential for definitive hematopoiesis ( Okuda et al., 1996 ; Wang et al., 1996 ), RUNX2 is crucial for skeletal development...

...Rohan J. Khadilkar; Guy Tanentzapf ABSTRACT Hematopoiesis requires coordinated cell signals to control the proliferation and differentiation of progenitor cells. In Drosophila , blood progenitors, called prohemocytes, which are located in a hematopoietic organ called the lymph gland, are regulated...

.... , Conway , S. J. , McGrath , K. E. and Palis , J. ( 2015 ). Definitive hematopoiesis in the Yolk Sac emerges from Wnt-responsive hemogenic endothelium independently of circulation and arterial identity . Stem Cells   34 , 431 - 444 . 10.1002/stem.2213 Goldie , L. C. , Lucitti...

...Chen U. Zhang; Ken M. Cadigan The lymph gland (LG) is a major source of hematopoiesis during Drosophila development. In this tissue, prohemocytes differentiate into multiple lineages, including macrophage-like plasmatocytes, which comprise the vast majority of mature hemocytes. Previous studies...

... hematopoiesis. * Author for correspondence ( lipsick@stanford.edu ) Competing interests The authors declare no competing or financial interests. 25 7 2016 20 2 2017 © 2017. Published by The Company of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1...

... heterogeneity affects leukemogenesis or treatment options. This Review provides a developmental overview of HSC subtypes during embryonic, fetal and adult stages of hematopoiesis and discusses the possible origins and consequences of HSC heterogeneity. Summary: This Review takes a close look...

.... Published by The Company of Biologists Ltd 2016 Summary: A new model for understanding the earliest steps of hematopoiesis is based on the in vitro recapitulation of hemogenic endothelium commitment from quail pre-somitic mesoderm. Hemogenic endothelium Hematopoiesis Endothelium Aorta...