... line in L) and in the posterior somites (encircled by a white line in O). Scale bars: 50 µm. To test whether the cells of the presumptive anterior paraxial mesoderm of SU5402-treated embryos expressing the axial mesoderm marker Goosecoid are incorporated in the notochord at later stages, we...

...Monica Dixon Fox; Ashley E. E. Bruce The organizer is essential for dorsal-ventral (DV) patterning in vertebrates. Goosecoid (Gsc), a transcriptional repressor found in the organizer, elicits partial secondary axes when expressed ventrally in Xenopus, similar to an organizer transplant. Although...

... for exploring the differentiation of definitive endoderm. In this study, we have established embryonic stem (ES) cell lines that carry GFP gene in the goosecoid ( Gsc ) gene locus and have investigated the differentiation course of mesendodermal cells using Gsc expression as a marker. Our results show...

... condensations are mispositioned and misshapen. Mirror-image hox2- dependent gene expression changes in postmigratory CNC prefigure the homeotic phenotype in moz mutants. Early second arch ventral expression of goosecoid ( gsc ) in moz mutants and in animals injected with hox2-MOs shifts from lateral to medial...

... the ossicles to the skull. Except for the stapes, these skeletal elements are unique to mammals and are derived from the first and second branchial arches. We show that, in combination with goosecoid ( Gsc ), the Bapx1 gene defines the structural components of the murine middle ear. During embryogenesis, Bapx1...

... throughout the blastoderm. Strikingly, following midblastula transition, nuclear-localized Eomesodermin is detected on the dorsal side of the embryo only. Overexpression of eomes results in Nodal-dependent and nieuwkoid / dharma ( nwk/dhm ) independent ectopic expression of the organizer markers goosecoid...

...-oncogene product. Mol. Cell. Biol. 5 , 3610 -3616. Filosa, S., Rivera-Perez, J. A., Gomez, A. P., Gansmuller, A.,Sasaki, H., Behringer, R. R. and Ang, S. L. ( 1997 ). Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124...

... Goosecoid Xnot Frzb Transcription Repressor Notochord Xwnt-8 BMP Xenopus Embryo Axial development in vertebrates is initiated and co-ordinated during gastrulation by a dorsal territory called the organiser. In amphibia, on the basis of molecular and embryological data ( Lemaire...

...Jie Yao; Daniel S. Kessler Formation of the vertebrate body plan is controlled by discrete head and trunk organizers that establish the anteroposterior pattern of the body axis. The Goosecoid (Gsc) homeodomain protein is expressed in all vertebrate organizers and has been implicated in the activity...

... oligonucleotides has little or no effect on the embryo. In contrast, embryos that lack both vox and vent function have a dorsalized phenotype. Expression of dorsal mesodermal genes, including chordin , goosecoid and bozozok , is strongly expanded in embryos that lack vox and vent function, indicating...

... does not remove all goosecoid - and floating head -expressing cells, suggesting that the morphological shield does not comprise the entire organizer region. Complete removal of the embryonic shield and adjacent marginal tissue, however, leads to a loss of both prechordal plate and notochord...

...Mariya Broun; Sergei Sokol; Hans R. Bode We have isolated Cngsc , a hydra homologue of goosecoid gene. The homeodomain of Cngsc is identical to the vertebrate (65-72%) and Drosophila (70%) orthologues. When injected into the ventral side of an early Xenopus embryo, Cngsc induces a partial secondary...

...Jaime A. Rivera-Pérez; Maki Wakamiya; Richard R. Behringer Mice homozygous for a targeted deletion of the homeobox gene Goosecoid ( Gsc ) have multiple craniofacial defects. To understand the mechanisms responsible for these defects, the behavior of Gsc -null cells was examined in morula...

..., the gene is not expressed. Previously, we have suggested that the suppression of Xbra by high concentrations of activin is due to the action of genes such as goosecoid and Mix . 1 . Here, we examine the roles played by goosecoid and Mix . 1 during normal development, first in the control of Xbra expression...

... Mandible Lim homeobox Fgf-8 Goosecoid Mouse Cell signalling The establishment of pattern during embryogenesis involves the cellular and molecular division of cells to provide ‘positional information’. Branchial arches give rise to a wide range of structures specific to each arch. Thus each...

... at low concentrations of fibronectin, show polarized protrusive activity, and form lamellipodia. Adhesion and polarization, but not lamellipodia formation, are mimicked by the immediate early response gene Mix . 1. Goosecoid , another immediate early gene, is without effect when expressed alone in animal...

...Beatriz Ferreiro; Michael Artinger; Ken W. Y. Cho; Christof Niehrs ABSTRACT goosecoid ( gsc ) is a homeobox gene expressed in the Spemann organizer that has been implicated in vertebrate axis formation. Here antimorphic gsc s are described. One antimorphic gsc (MT gsc ) was fortuitously created...

...Carolina Mailhos; Sylvain André; Bertrand Mollereau; Anne Goriely; Ali Hemmati-Brivanlou; Claude Desplan ABSTRACT Goosecoid (Gsc) is a homeodomain protein expressed in the organizer region of vertebrate embryos. Its Drosophila homologue, D-Gsc, has been implicated in the formation...

... siamois ( Xsia ) suggesting that Xtwn and Xsia comprise a new subclass of homeobox genes important in dorsal axis specification. We find that Xtwn is able to activate the Spemann organizerspecific gene goosecoid ( gsc ) via direct binding to a region of the gsc promoter previously shown to mediate Wnt...

... territories of the zebrafish gastrula. * Author for correspondence (e-mail: thisse@titus.u-strasbg.fr ) 25 08 1997 © 1997 by Company of Biologists 1997 fgf-8 Spemann’s organizer gastrulation dorsoventral patterning convergence BMP2 BMP4 Chordin Noggin Goosecoid...