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Keywords: gastrulation
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2023) 150 (2): dev201119.
Published: 18 January 2023
...Lenin Chandran; Wilko Backer; Raphael Schleutker; Deqing Kong; Seyed A. H. Beati; Stefan Luschnig; H.-Arno J. Müller ABSTRACT Src kinases are important regulators of cell adhesion. Here, we have explored the function of Src42A in junction remodelling during Drosophila gastrulation. Src42A...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (21): dev200292.
Published: 31 October 2022
... enrichment and polarisation at parasegmental boundaries (PSBs) in early Drosophila embryos, from the start of germband extension at gastrulation and throughout the germband extended stages (stages 6 to 11). First, we find that Tartan is required during germband extension for actomyosin enrichment at PSBs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (19): dev200785.
Published: 12 October 2022
...Isabell Niedermoser; Tatiana Lebedeva; Grigory Genikhovich ABSTRACT Canonical Wnt (cWnt) signalling is involved in a plethora of basic developmental processes such as endomesoderm specification, gastrulation and patterning the main body axis. To activate the signal, Wnt ligands form complexes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200335.
Published: 11 July 2022
... transcription factor eomesodermin can replace Wnt priming in the differentiation of human embryonic stem cells into mesendoderm. Activin/nodal signaling Eomesodermin Wnt signaling Gastrulation Human embryonic stem cells Mesendodermal differentiation National Institutes of Health R35...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (13): dev200083.
Published: 8 July 2022
... oscillations linked to the segmentation clock are synchronized across cells in the presomitic mesoderm (PSM) and result in tissue-level wave patterns. To examine their onset during mouse embryo development, we studied the dynamics of the segmentation clock gene Lfng during gastrulation. To this end, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200303.
Published: 20 June 2022
... the primitive streak, the site of gastrulation. The more external extra-embryonic region (area opaca) was thought to have only nutritive and support functions. Using experimental embryology approaches, this study reveals three separable functions for this outer region. First, juxtaposition of the area opaca...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (10): dev200295.
Published: 16 May 2022
... in a morphogen gradient . Development 126 , 5309 - 5317 . 10.1242/dev.126.23.5309 Gustafson , T. and Wolpert , L. ( 1961 ). Studies on the cellular basis of morphogenesis in the sea urchin embryo. Gastrulation in vegetalized larvae . Exp. Cell Res. 22 , 437 - 449 . 10.1016/0014...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev199743.
Published: 23 March 2022
... humans and farm ungulates. The developmental events occurring following hatching in ungulates include the proliferation and maturation of extra-embryonic membranes – trophoblast and hypoblast – and the formation of a flat embryonic disc, similar to that found in humans, which initiates gastrulation prior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200468.
Published: 18 March 2022
... domains during epithelial folding and a role for Dlg1 in coordination of this process. Apical constriction Apical-basal polarity Dlg1 Epithelial folding Gastrulation Ventral furrow National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35GM128745...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200319.
Published: 18 February 2022
...Yuki Naitou; Go Nagamatsu; Nobuhiko Hamazaki; Kenjiro Shirane; Masafumi Hayashi; Makoto Hayashi; Satoru Kobayashi; Katsuhiko Hayashi ABSTRACT In mammals, primordial germ cells (PGCs), the origin of the germ line, are specified from the epiblast at the posterior region where gastrulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199991.
Published: 17 December 2021
... the role of the Dorsal protein nuclear gradient along the dorsoventral axis in defining the graded pattern of actomyosin constriction that initiates gastrulation in early Drosophila embryos. Two complementary mechanisms for graded accumulation of mRNAs of crucial zygotic Dorsal target genes were identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199725.
Published: 15 September 2021
....2014.087 Gheisari , E. , Aakhte , M. and Müller , H.-A. J. ( 2020 ). Gastrulation in Drosophila melanogaster: genetic control, cellular basis and biomechanics . Mech. Dev. 163 , 103629 . 10.1016/j.mod.2020.103629 Haase , R. , Royer , L. A. , Steinbach , P...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev193128.
Published: 24 June 2021
... proliferation are tightly controlled during gastrulation. Following mitosis, a negative-feedback mechanism resets Cdk1 activity through Cdk1-dependent activation of the anaphase-promoting complex/cyclosome (APC/C) ( Pines, 2011 ) ( Fig. 1 Aii). The APC/C is a large complex of proteins that has E3-ubiquitin...
Journal Articles
Journal: Development
Development (2021) 148 (10): dev196089.
Published: 17 May 2021
... development, as well as in morphogenetic movements of gastrulation and axial elongation. Our findings suggest that the mesoderm-inducing role of FGF extends beyond the group of deuterostomes. Embryos were permeabilized in 100% methanol for 1 h, digested with Proteinase K (10 µg ml −1 ; Sigma-Aldrich...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev198960.
Published: 29 March 2021
...Martina Nagel; Debanjan Barua; Erich W. Damm; Jubin Kashef; Ralf Hofmann; Alexey Ershov; Angelica Cecilia; Julian Moosmann; Tilo Baumbach; Rudolf Winklbauer ABSTRACT During Xenopus gastrulation, leading edge mesendoderm (LEM) advances animally as a wedge-shaped cell mass over the vegetally moving...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (4): dev180612.
Published: 16 February 2021
... and regenerative medicine. Axis elongation Gastrulation Neuromesodermal progenitors Primitive streak Tail bud Pluripotent stem cells Lineage specification in the early vertebrate embryo is initiated during gastrulation (see Glossary, Box 1 ), which involves the formation of the three germ...
Journal Articles
Journal: Development
Development (2021) 148 (1): dev193789.
Published: 7 January 2021
... fate labeling and imaging approaches with single-cell RNA sequencing (scRNA-seq) to follow the transcriptional identities and define lineage trajectories of Eomes -dependent cell types. Accordingly, all cells moving through the PS during the first day of gastrulation express Eomes . AM and DE...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186965.
Published: 14 August 2020
...Ulla-Maj Fiuza; Takefumi Negishi; Alice Rouan; Hitoyoshi Yasuo; Patrick Lemaire ABSTRACT Gastrulation is the first major morphogenetic event during animal embryogenesis. Ascidian gastrulation starts with the invagination of 10 endodermal precursor cells between the 64- and late 112-cell stages...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (12): dev186999.
Published: 17 June 2020
..., the requirements of these paralogs in mammalian development have only been incompletely reported. Here, we examined the null phenotypes to establish that MLL3 is first required for lung maturation, whereas MLL4 is first required for migration of the anterior visceral endoderm that initiates gastrulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev188714.
Published: 26 May 2020
... , Mrpl44 , Mrps18c and Mrps22 . Loss of each MRP results in successful implantation and egg-cylinder formation, followed by severe developmental delay and failure to initiate gastrulation by embryonic day 7.5. The robust and similar single knockout phenotypes are somewhat surprising given there are over 70...