... domain of Fused (Fu) and highly activate its kinase activity. We further show that this binding induces changes in the association of Fu protein with the HSC and increases the proximity of the Fu catalytic domain to its substrate, the Costal2 kinesin. We propose a new model in which, depending...

... transcription factors, Drosophila Cubitus interruptus (Ci) and mammalian Gli proteins. Cos2 and Kif7 are also necessary for full activation of full-length Ci-155 and Gli transcription factors in response to Hh proteins. Here, we use classical fused alleles and transgenic Cos2 products deficient for Fused (Fu...

... of or in parallel with Hedgehog signaling and (3) the Hedgehog signaling pathway required for Bolwig’s organ development is a new type and lacks Fused kinase and Cubitus interruptus as downstream components. * Author for correspondence (e-mail: saigo@biochem.s.u-tokyo.ac.jp ) 02 09 200 18 01 2000...

... © 1999 by Company of Biologists 1999 Drosophila melanogaster cubitus interruptus hedgehog NLS PKA fused costal-2 During development, organs and tissues must be precisely patterned. Cell-cell signaling is the primary mechanism by which the relative position and hence...

... side of cells where it is produced. Thus responsive embryonic cells appear to react according to their position relative to the Hedgehog source. The molecular basis of these differences is still largely unknown. In this paper we show that one component of the Hedgehog pathway, the Fused kinase...

... rise to sensory organs and migrate along the nerve following the direction taken by axons. As in vertebrates, wing glial cells start migrating at a stage at which axons are growing. The migration of wing glial cells is affected by two mutations altering axonogenesis, fused and Notch , which suggests...

... by the activity of four other segment polarity genes, patched, fused, costal-2 and cubitus interruptus . The results of our genetic epistatsis analysis together with the molecular structures of the products of these genes where known, suggest a pathway of interactions leading from reception of the Aft-encoded...

...Bernadette Limbourg-Bouchon; Denise Busson; Claudie Lamour-Isnard ABSTRACT Fused (fu) is a segment polarity gene whose product is maternally required in the posterior part of each segment. To define further the role of fused and determine how it interacts with other segmentation genes, we examined...