.... 1 , Fig. 2 C). Fig. 2. The Dachsous/Fat system. (A) Gradients of expression of the four-jointed ( fj ) and dachsous ( ds ) genes, driven by morphogens such as Hedgehog, are translated into the asymmetric distribution of Ds/Ft bridges within each cell and coordinate polarity of all...

... be eliminated when D/V patterning is disrupted and can be induced in situations in which ectopic boundaries are artificially generated. We also show that emc functions downstream of Notch signaling to maintain the expression of four-jointed along the midline. * Author for correspondence ( jkumar...

...José Casal; Peter A. Lawrence; Gary Struhl Planar polarity is a fundamental property of epithelia in animals and plants. In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed...

... Four-jointed Dachs Frizzled Grunge Atrophin The Drosophila proteins Fat (Ft) and Dachsous (Ds) are required in several processes during the development of imaginal disc tissues. First, they help regulate the growth of discs. Removal of Ft and, to a lesser extent, Ds,induces...

...Helen Strutt; Jenifer Mundy; Katrina Hofstra; David Strutt four-jointed ( fj ) is required for proximodistal growth and planar polarity in Drosophila tissues. It encodes a predicted type II transmembrane protein with putative signal peptidase sites in its transmembrane domain, and its C terminus...

... the proximal boundary of the inner ring-like domain of wg expression( Fig. 5J ). By contrast, the expression domain of dve is larger than that of the four-jointed ( fj ) gene, which is expressed in a similar pattern to vg ( Fig. 5I ). The results of the comparison of the expression domains...

...Gerri R. Buckles; Cordelia Rauskolb; John Lee Villano; Flora N. Katz The molecular basis of segmentation and regional growth during morphogenesis of Drosophila legs is poorly understood. We show that four-jointed is not only required for these processes, but also can direct ectopic growth and joint...

...J. Lee Villano; Flora N. Katz ABSTRACT Genes capable of translating positional information into regulated growth lie at the heart of morphogenesis, yet few genes with this function have been identified. Mutants in the Drosophila four-jointed ( fj) gene show reduced growth and altered...