...) severe retinal defects accompany its loss; (3) Pax6 genes have the ability to substitute for one another across the animal kingdom; and (4) Pax6 genes are capable of inducing ectopic eye/lens in flies and mammals. Many roles of Pax6 were first elucidated in Drosophila through studies of the gene eyeless...

...Tianyi Zhang; Swati Ranade; Chuan Qi Cai; Christopher Clouser; Francesca Pignoni During eye development, the selector factors of the Eyeless/Pax6 or Retinal Determination (RD) network control specification of organ-type whereas the bHLH-type proneural factor Atonal drives neurogenesis. Although...

...Tobias Pauli; Makiko Seimiya; Jorge Blanco; Walter J. Gehring In Drosophila , the sine oculis ( so ) gene is important for the development of the entire visual system, including Bolwig's organ, compound eyes and ocelli. Together with twin of eyeless , eyeless , eyes absent and dachshund , so...

... cause reduction or absence of the eye. Similar to the Pax6 eyeless ( ey ) gene, ectopic expression of eyg induces extra eye formation, but at sites different from those induced by ey . Several lines of evidence suggest that eyg and ey act cooperatively: (1) eyg expression is not regulated by ey , nor...

...Jesper Kronhamn; Erich Frei; Michael Daube; Renjie Jiao; Yandong Shi; Markus Noll; Åsa Rasmuson-Lestander The two Pax6 gene homologs eyeless and twin of eyeless play decisive early roles in Drosophila eye development. Strong mutants of twin of eyeless or of eyeless are headless, which suggests...

... by Eyeless and generates headless flies, which suggests that Eyeless is necessary for initiating cell proliferation and development of both the eye and antennal disc. Interference occurs through a block in the cell cycle that for some ectopic transcription factors is overcome by D-CycE or D-Myc. Late ectopic...

... rise to the mushroom body and follow its morphogenesis through later embryonic stages. In the late embryo, axons of MB neurons lay down a characteristic pattern of pathways. eyeless ( ey ) and dachshund ( dac ) are expressed in the progenitor cells and neurons of the MB in the embryo and larva...

... describe the temperature-sensitive mutation eyeless in the Japanese medakafish. Marker gene analysis indicates that, whereas, specification of two retinal primordia and proximodistal patterning takes place in the mutant embryo, optic vesicle evagination does not occur and subsequent differentiation...

... isolated from a wide variety of organisms ranging from flatworms to humans. Since loss-of-function mutants in insects and mammals lead to an eyeless phenotype and Pax-6 orthologs from distantly related species are capable of inducing ectopic eyes in Drosophila , we have proposed that Pax-6 is a universal...

...Rui Chen; Georg Halder; Zhihuan Zhang; Graeme Mardon Retinal cell fate determination in Drosophila is controlled by an interactive network of genes, including eyeless, eyes absent, sine oculis and dachshund . We have investigated the role of the TGF-β homolog decapentaplegic in this pathway. We...

... of the Drosophila eyeless gene, a Pax6 homolog, directs eye- and CNS-specific expression in transgenic mice that accurately reproduces features of endogenous Pax6 expression. These results suggest that in addition to conservation of Pax6 function, the upstream regulation of Pax6 has also been conserved during...

...Georg Halder; Patrick Callaerts; Susanne Flister; Uwe Walldorf; Urs Kloter; Walter J. Gehring ABSTRACT The Drosophila Pax-6 gene eyeless acts high up in the genetic hierarchy involved in compound eye development and can direct the formation of extra eyes in ectopic locations. Here we identify sine...

... and that of the eyeless gene, a Pax-6 homolog, critical for eye formation in both flies and man, was defined: eya was found to be essential for eye formation by eyeless . Moreover, eya could itself direct ectopic eye formation, indicating that eya has the capacity to function as a master control gene for eye formation...

... ectopic retinal development in a variety of tissues, including the adult head, thorax and legs. This result is similar to that observed with the highly conserved Drosophila gene eyeless , which can induce ectopic eye formation on all major appendages. Here, we show that dachshund and eyeless induce...