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Keywords: engrailed
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Journal Articles
Journal: Development
Development (2017) 144 (18): 3224–3231.
Published: 15 September 2017
... enhancer responsible for dpp expression in imaginal discs. Our data demonstrate that Engrailed, a homeodomain-containing transcription factor that serves as a cap cell marker, binds to this region and regulates dpp expression in cap cells. Further data suggest that En forms a complex with Nejire (Nej...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (1): 82–92.
Published: 1 January 2013
... expression – the prospective anterior and posterior ocelli – and the intervening interocellar domain. Our results highlight the role of the homeodomain transcription factor engrailed ( en ) both as a target and as a transcriptional repressor of hh signaling in the prospective interocellar region. Furthermore...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (3): 525–536.
Published: 1 February 2012
... induces neural apoptosis and extinction of MHB markers, which are rescued by re-expression of engrailed 2a ( eng2a ), an evolutionarily conserved target of the Grhl family. Co-injection of sub-phenotypic doses of grhl2b and eng2a morpholinos reproduces the apoptosis and MHB marker loss, but fails...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (1): 215–224.
Published: 1 January 2012
...Olivier Stettler; Rajiv L. Joshi; Andrea Wizenmann; Jürgen Reingruber; David Holcman; Colette Bouillot; François Castagner; Alain Prochiantz; Kenneth L. Moya Engrailed 1 and engrailed 2 homeoprotein transcription factors (collectively Engrailed) display graded expression in the chick optic tectum...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2315–2323.
Published: 1 June 2011
.... In vertebrates, several homeoproteins have also been shown to have direct non-cell-autonomous activities in the developing nervous system. We present the first in vivo evidence for homeoprotein signaling in Drosophila . Focusing on wing development as a model, we first demonstrate that the homeoprotein Engrailed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (7): 1285–1295.
Published: 1 April 2011
... and for transcription of a core set of midline glial-expressed genes. The Hedgehog morphogen is secreted from ectodermal cells adjacent to the CNS midline and directs a subset of midline glia to become PMG. Two transcription factor genes, runt and engrailed , play important roles in AMG and PMG development. The runt...
Journal Articles
Journal: Development
Development (2011) 138 (4): 755–765.
Published: 15 February 2011
.... * Author for correspondence ( pingham@imcb.a-star.edu.sg ) Competing interests statement 3 12 2010 © 2011. BMP Smad BiFC Engrailed Patched Gli Sonic Hedgehog Myotome Muscle pioneers Zebrafish Members of the Hedgehog (Hh) family of signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 97–106.
Published: 1 January 2011
...Morgane Dolez; Jean-François Nicolas; Estelle Hirsinger In zebrafish, Hedgehog-induced Engrailed expression defines a muscle fibre population that includes both slow and fast fibre types and exhibits an organisational role on myotome and surrounding tissues, such as motoneurons and lateral line...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (17): 2885–2894.
Published: 1 September 2010
...Caroline C. G. Fabre; José Casal; Peter A. Lawrence The abdomen of adult Drosophila bears mechanosensory bristles with axons that connect directly to the CNS, each hemisegment contributing a separate nerve bundle. Here, we alter the amount of Engrailed protein and manipulate the Hedgehog signalling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3433–3442.
Published: 15 October 2009
... identified on the basis that they express the homeobox gene engrailed ( en ). For each lineage,we determine the total number of adult-specific neurons generated as well as number and pattern of en -expressing cells. We then demonstrate that programmed cell death has a pronounced effect on the number of cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (19): 3219–3228.
Published: 1 October 2008
... repression of Ubx transcription. Similar results are obtained with the gene engrailed , showing that this mechanism of permanent repression may be a general one for genes with negative auto-regulation when levels of expression are transitorily elevated. * Author for correspondence (e-mail: esherrero...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (6): 1001–1012.
Published: 15 March 2006
..., a combination of repression by Wingless and activation by Hedgehog induces expression of the proneural gene lethal of scute in the most anterior midline daughter cells of the neighbouring posterior segment. Hedgehog and Lethal of scute activate Engrailed in these anterior cells. Engrailed-positive midline cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 739–749.
Published: 15 February 2005
...Giuseppe Cassata; Gidi Shemer; Paolo Morandi; Roland Donhauser; Benjamin Podbilewicz; Ralf Baumeister engrailed is a homeobox gene essential for developmental functions such as differentiation of cell populations and the onset of compartment boundaries in arthropods and vertebrates. We present...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (17): 4143–4153.
Published: 1 September 2004
... the leech engrailed -class gene in the early N lineage ( Wedeen and Weisblat, 1991 ; Lans et al.,1993 ). In Drosophila, engrailed is expressed in stripes of cells that specify the posterior compartment of each segment( Kornberg, 1981a ; Kornberg, 1981b ; Lawrence et al., 1999a ). By acting upstream...
Journal Articles
Journal: Development
Development (2004) 131 (14): 3249–3262.
Published: 15 July 2004
... 3 2004 © 2004. 2004 Dermomyotome Slow muscle MyoD Pax3 Myf5 Engrailed During vertebrate skeletal muscle development, several populations of myogenic cells arise within each somite due, at least in part, to signals impinging on the somite from neighbouring tissues( Borycki...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2281–2290.
Published: 15 May 2004
... ) and engrailed ( en ). However, in the case of en the combination of Runt +Ftz gives activation. The contrasting responses of different downstream targets to Runt in the presence or absence of Ftz is thus central to the combinatorial logic of the pair-rule to segment-polarity transition. The unique and simple...
Journal Articles
Journal: Development
Development (2003) 130 (23): 5625–5635.
Published: 1 December 2003
...Camilla W. Larsen; Elizabeth Hirst; Cyrille Alexandre; Jean-Paul Vincent In Drosophila embryos, segment boundaries form at the posterior edge of each stripe of engrailed expression. We have used an HRP-CD2 transgene to follow by transmission electron microscopy the cell shape changes that accompany...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2003) 130 (22): 5319–5330.
Published: 15 November 2003
... Engrailed Otx2 Swaying Chick-quail chimera Mouse References Ackerman, S. L., Kozak, L. P., Przyborski, S. A., Rund, L. A.,Boyer, B. B. and Knowles, B. B. ( 1997 ). The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature 386 , 838 -842. Alcántara, S...
Journal Articles
Journal: Development
Development (2003) 130 (20): 4881–4893.
Published: 15 October 2003
... the establishment and maintenance of the diencephalic-mesencephalic boundary (DMB). We show that maintenance of the DMB requires both the presence of a specified midbrain and a functional MHB organizer. Expression of pax6.1 , a key regulator of forebrain development, is posteriorly suppressed by the Engrailed...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1281–1294.
Published: 1 April 2003
... Otx XOtx2 XOtx5 XOtx5b Bipolar cell Photoreceptor VP16 Engrailed Xenopus laevis Opsin Lipofection Rod photoreceptors and bipolars are among the last cells to be born and differentiate from the late-progenitor pool( Carter-Dawson and LaVail,1979 ; Chang and Harris,1998 ; Holt et...