... distribution of competence is established during gastrulation paralleling the dorsal restriction of neural competence. We further show that Dlx3 and GATA2 are required cell-autonomously for panplacodal and epidermal marker expression in the non-neural ectoderm, while ectopic expression of Dlx3 or GATA2...

...Joonsung Hwang; Taraneh Mehrani; Sarah E. Millar; Maria I. Morasso Dlx homeobox transcription factors regulate epidermal, neural and osteogenic cellular differentiation. Here, we demonstrate the central role of Dlx3 as a crucial transcriptional regulator of hair formation and regeneration...

...-mesenchymal interactions during development. Dlx3 and p63 act as part of the transcriptional regulatory pathways relevant in ectoderm derivatives, and autosomal mutations in either of these genes are associated with human EDs. However, the functional relationship between both proteins is unknown. Here,we...

... for all embryos. Both set of experiments indicate that Sox9 is strictly required for specification of the otic placode and that subsequent otic vesicle differentiation and patterning can occur independently of Sox9 function. The distal-less related homeobox gene Dlx3 is expressed during...

... deletion removes several known genes and expressed sequence tags, including dlx3 and dlx7 , two transcription factors that share a homoeobox domain similar in sequence to the Drosophila Distal-less gene. dlx3 and dlx7 are expressed in an overlapping pattern in the regions that produce the otic...