...Jan A. Adelmann; Roman Vetter; Dagmar Iber ABSTRACT Tissue patterning during embryonic development is remarkably precise. Here, we numerically determine the impact of the cell diameter, gradient length and the morphogen source on the variability of morphogen gradients. We show that the positional...

...Lucie Wolf; Michael Boutros ABSTRACT Intercellular communication by Wnt proteins governs many essential processes during development, tissue homeostasis and disease in all metazoans. Many context-dependent effects are initiated in the Wnt-producing cells and depend on the export of lipidated Wnt...

.... Taken together, our work provides a benchmark for 3D MG analysis across MG visualization techniques, developmental ages, and species. Fig. 1. GliaMorph workflow overview. (A) Using global image-level measurements, we developed a tool to quantify 11 different parameters of MG morphology. (B...

... scRNA-seq datasets in the developing mouse and human fetal retinas ( Clark et al., 2019 ; Lu et al., 2020 ). Focusing on the RPC population, we generated UMAP plots by sub-setting the RPC populations at various developmental stages. We found that Ikzf4 / IKZF4 mRNA is expressed in both early and late...

... for normal brain development . Science 333 , 1456 - 1458 . 10.1126/science.1202529 Piochon , C. , Kano , M. and Hansel , C. ( 2016 ). LTD-like molecular pathways in developmental synaptic pruning . Nat. Neurosci. 19 , 1299 - 1310 . 10.1038/nn.4389 Pollak Dorocic...

..., promoting further maturation would enable us to study postnatal development and improve modelling of adult-onset diabetes. Benchmarking the nature of the cells generated in organoids and their maturity will be important to tackle these questions and understand the developmental stages modelled as well...

...-dependent metabolism functionally participates in nephron progenitor maintenance by monitoring pyruvate and proline biogenesis in developing kidneys. * These authors contributed equally to this work ‡ Author for correspondence ( satu.kuure@helsinki.fi ) Handling Editor: Irene Miguel-Aliaga...

... , 2426 - 2428 . 10.1093/bioinformatics/btr398 Bolt , C. C. and Duboule , D. ( 2020 ). The regulatory landscapes of developmental genes . Development 147 , dev171736 . 10.1242/dev.171736 Bolt , C. C. , Lopez-Delisle , L. , Mascrez , B. and Duboule , D...

... physiological Notch signals are not acting to switch cells from self-renewal to differentiation, Notch signals could promote proximal development within a developmental window, defined pharmacologically with γ-secretase inhibitors ( Cheng et al., 2003 , 2007 ). This role would predict that if Notch contributed...

... with traditional models. Finally, iPSC-derived organoid systems have also become increasingly popular as a tool to study human development and organogenesis, but many of them are lacking in the developmental cues provided by RTMs and, as such, might not be fully representative. It would be interesting to see...

..., are enlarged and accumulate massively at the last larval and white prepupal stage ( Rusten et al., 2004 ; Butterworth et al., 1988 ; Butterworth and Forrest, 1984 ). The steroid hormone ecdysone, the master regulator of insect development, drives developmental autophagy in the fat body through downregulation...

... of Biologists Ltd 2022 Summary: Single cell transcriptomics and genetic studies reveal unique properties of Olig2-expressing neural stem cells in the adult subventricular zone and their developmental trajectory. Neural stem cell Adult neurogenesis Regional identity Olfactory bulb Development...

... are no longer present, with the new methylation pattern itself thus serving as a template of stable cell identity ( Mayran et al., 2018 ; Reizel et al., 2021 ). The process of cell fate determination during development is largely directed by local morphogens, which serve as developmental signals...

... is the prime organizing center for axial elongation in mouse embryos. The T-box transcription factor brachyury (T) is essential for both formation of the notochord and maintenance of NMPs, and thus is a key regulator of trunk and tail development. The T promoter controlling T expression in NMPs and nascent...

... by HIF2α, suggesting that at least some roles are unique. Tissue-specific gene-targeting studies also revealed developmental defects specifically associated with HIF1α or HIF2α deficiency. ARNT and ANRT2 also display partially overlapping roles, with ARNT being the major isoform required for development...

...Eunice H. Y. Chan; Yanxiang Zhou; Birgit L. Aerne; Maxine V. Holder; Anne Weston; David J. Barry; Lucy Collinson; Nicolas Tapon ABSTRACT Cell-cell junctions are dynamic structures that maintain cell cohesion and shape in epithelial tissues. During development, junctions undergo extensive...

... in Development and Disease’, organized by Irene Miguel-Aliaga, Ralph DeBerardinis and Marian Walhout, it became clear that the field of developmental and disease metabolism is maturing and moving on. Over the course of these 2 days, the work of Warburg, and the important influence it long had on this budding...

... , A . ( 2018 ). Cortical developmental death: selected to survive or fated to die . Curr. Opin. Neurobiol. 53 , 35 - 42 . 10.1016/j.conb.2018.04.022 Ceranik , K. , Zhao , S. and Frotscher , M . ( 2000 ). Development of the entorhino-hippocampal projection: guidance by Cajal-Retzius...

... epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation . Development 132 , 4533 - 4544 . 10.1242/dev.02019 Kerever , A. , Schnack , J. , Vellinga , D. , Ichikawa , N. , Moon , C. , Arikawa-Hirasawa...

... still have limited understanding of the dynamics of electrical fields across tissues and structures during development, and further empirical analysis is required. One of the key transformative concepts within developmental biology is that of the morphogenetic field (reviewed by Gilbert et al...