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Keywords: chimaera
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Journal Articles
Journal: Development
Development (2023) 150 (14): dev201756.
Published: 24 July 2023
..., in the preimplantation genetic diagnosis of human embryos. Another manifestation of this developmental plasticity is the possibility of obtaining chimaeras by combining either two embryos or embryos and pluripotent stem cells, which enables the verification of the cell pluripotency and generation of genetically modified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (1): 24–34.
Published: 1 January 2016
... a minority of the embryonic stem cell (ESC) inoculum contributes to the adult chimaera. How incoming cells are chosen for integration or elimination remains unclear. By comparing a heterogeneous mix of undifferentiated and differentiating ESCs (serum/LIF) with more homogeneous undifferentiated culture (2i...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1001–1010.
Published: 1 March 2014
.../by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Blastocyst Chimaera Nanog Oct4 (Pou5f1) Primitive endoderm Sox17 A prerequisite for the viviparous development of the mouse embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3499–3510.
Published: 1 September 2013
... ) Competing interests statement The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Chimaera Developmental plasticity Regulative development Stochastic gene expression Twin One of the most intriguing observations...
Journal Articles
Journal: Development
Development (2009) 136 (7): 1063–1069.
Published: 1 April 2009
...Ge Guo; Jian Yang; Jennifer Nichols; John Simon Hall; Isobel Eyres; William Mansfield; Austin Smith Mouse embryonic stem (ES) cells derived from pluripotent early epiblast contribute functionally differentiated progeny to all foetal lineages of chimaeras. By contrast, epistem cell (EpiSC) lines...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1597–1607.
Published: 15 April 2006
... defect of the epiblast cells and is rescued by complementation of NT blastocysts with normal ES or ICM cells. The second type of defect affects growth regulation and the shape of the embryo but does not directly impair the initial establishment of the patterning of the embryo. Only chimaeras formed...
Journal Articles
Journal: Development
Development (1999) 126 (16): 3473–3483.
Published: 15 August 1999
...Marie-José Goumans; An Zwijsen; Marga A. van Rooijen; Danny Huylebroeck; Bernard A. J. Roelen; Christine L. Mummery We have analysed the function of transforming growth factor β (TGF-β) in yolk sac development in mice by generating somatic chimaeras in which the extraembryonic mesoderm, which gives...
Journal Articles
Journal: Development
Development (1998) 125 (13): 2397–2402.
Published: 1 July 1998
... of Biologists 1998 Epiblast growth Clonal analysis Epiblast founder cell Intercellular bridge Visceral endoderm Coherent clonal growth Fluorescein complexon Tetramethylrhodamine dextran lysin biotin Chimaera Mouse Whilst there is little relative movement of cells during...
Journal Articles
Journal: Development
Development (1990) 110 (4): 1241–1248.
Published: 1 December 1990
... to another. In contrast, a high and reproducible degree of chimaerism was obtained when the ES cells were injected at the morula stage prior to ICM formation. 25 08 1990 © 1990 by Company of Biologists 1990 embryonic stem cells chimaera mouse embryo β-galactosidase marker...
Journal Articles
Journal: Development
Development (1989) 105 (4): 733–737.
Published: 1 April 1989
...R. S. P. Beddington; E. J. Robertson ABSTRACT Embryonic stem cells (ES) cells were injected into host blastocysts either in groups of 10–15 cells or as single cells in order to test their developmental potential in the developing embryo. The analysis of midgestation chimaeras, by electrophoretic...
Journal Articles
Journal Articles
Journal: Development
Development (1988) 103 (4): 785–790.
Published: 1 August 1988
... on chimaeric villi in the neonate shows a mottled pattern of mosaicism which is progressively replaced by coherent sheets of cells from the crypts, and within two weeks the orderly adult clonal pattern is established. © 1988 by Company of Biologists 1988 chimaera mouse intestine crypt killus...
Journal Articles
Journal Articles
Journal: Development
Development (1988) 102 (4): 763–772.
Published: 1 April 1988
... if similar influences are associated with embryonic fibre-type differentiation, the limb musculature of intraspecific (chick/chick) chimaeras was assessed using differential myosin-ATPase activity. The limb musculature analysed histochemically was derived from donor unsegmented thoracic somitic mesoderm...
Journal Articles
Journal: Development
Development (1987) 101 (1): 67–71.
Published: 1 September 1987
...A. Nagy; A. Páldi; L. Dezso; L. Varga; A. Magyar ABSTRACT Parthenogenetically activated BCF1 and fertilized BALB/c embryos were aggregated to form chimaeras. The fate of the parthenogenetic component was followed in the conceptus during the second half of gestation. The results indicate an early...
Journal Articles
Journal: Development
Development (1987) 100 (3): 535–541.
Published: 1 July 1987
... was markedly different. There were no stripes anywhere from the midthoracic region to the groin, but a straight midventral clonal boundary was observed. These findings were consistent in chimaeras of each of the three strain combinations studied. The lack of obvious ventral striping in epidermis suggests...
Journal Articles
Journal: Development
Development (1987) 99 (2): 187–196.
Published: 1 February 1987
... of patches per unit area was consistent between the simulation and the chimaeric tissue. * To whom correspondence should be addressed 06 10 1986 © 1987 by Company of Biologists 1987 rat liver chimaera pattern formation mosaic tissues computer simulation Chimaeric...
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