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Keywords: cell fate
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Journal Articles
Journal: Development
Development (2022) 149 (15): dev200642.
Published: 8 August 2022
... in the adult mouse and human retina, including a conserved region nearby Prdm1 , a factor implicated in the specification of rod photoreceptors and suppression of bipolar cell fate. VSX2 interacts with the transcription factor OTX2 and can act to suppress OTX2-dependent enhancer transactivation of the Prdm1...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (14): dev200501.
Published: 28 July 2022
... pellucida, highlighting a potential risk of sexually transmitted infection in early pregnancy. Zika virus (ZIKV) Birth defects Miscarriage Developmental biology Cell fate Epidemic Michigan State University http://dx.doi.org/10.13039/100007709 National Institute of General...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev200375.
Published: 25 March 2022
... precursor pool. Sustained Wt1 expression in cardiomyocytes can change their cell fate into epicardial-like cells. wt1a wt1b Heart development Cardiomyocyte Epicardium Zebrafish Cell fate Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung http...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199853.
Published: 28 January 2022
... Cell fate Cell plasticity Diabetes European Research Council http://dx.doi.org/10.13039/100010663 ERC-StG 715361 SPACEVAR Fonds de la Recherche Scientifique 34772792 – SCHISM Technische Universitat Dresden Deutsches Zentrum für Diabetesforschung...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199634.
Published: 24 January 2022
... results from M cells prematurely adopting a head epidermis fate. This switch in fate normally takes place during pupal development after the eye has been patterned. Our results suggest that the timing of cell fate decisions is essential for correct eye development. * Author for correspondence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev194407.
Published: 24 January 2022
... of the Wnt/β-catenin pathway, which is required for melanocyte development, induces activation of Mitf-M, in turn repressing FoxD3 expression. In conclusion, β-catenin overexpression promotes SCP cell fate decisions towards the melanocyte lineage. Fig. 6. The number of paw melanoblasts increases...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (2): dev199484.
Published: 17 January 2022
.... , Fujitani , S. , Luo , H. , Qiu , F. , Burlison , J. , Long , Q. , Kawaguchi , Y. , Edlund , H. , Macdonald , R. J. , Furukawa , T. et al. ( 2006 ). Ptf1a determines horizontal and amacrine cell fates during mouse retinal development . Development 133 , 4439...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (24): dev199779.
Published: 22 December 2021
...Megan K. Rommelfanger; Adam L. MacLean ABSTRACT Cells do not make fate decisions independently. Arguably, every cell-fate decision occurs in response to environmental signals. In many cases, cell-cell communication alters the dynamics of the internal gene regulatory network of a cell to initiate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199609.
Published: 12 June 2021
...Lluc Mosteiro; Hanaa Hariri; Jelle van den Ameele ABSTRACT The intimate relationships between cell fate and metabolism have long been recognized, but a mechanistic understanding of how metabolic pathways are dynamically regulated during development and disease, how they interact with signalling...
Journal Articles
Journal: Development
Development (2021) 148 (4): dev196030.
Published: 15 February 2021
...Natalie J. Milmoe; Abigail S. Tucker ABSTRACT Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This starts with the neural crest, which undergoes epithelial-to-mesenchymal transition (EMT) to form, amongst other tissues, many of the skeletal tissues...
Journal Articles
Journal: Development
Development (2020) 147 (18): dev188730.
Published: 28 September 2020
... of Biologists Ltd 2020 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Pou2f1 upregulates Pou2f2 expression, which in turn represses the rod-promoting factor Nrl to control the timing of cone genesis in the mouse retina. Cell fate Mouse Photoreceptors Retina Temporal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (15): dev186965.
Published: 14 August 2020
... ascidian endoderm invagination, and shows that fate specification is in part uncoupled from the control of morphogenesis in early ascidian embryos. Nodal Ephrin Gastrulation Morphogenesis Cell fate Epithelial invagination, the buckling of a sheet of cells into a cup-like structure...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (14): dev190629.
Published: 17 July 2020
...Marta N. Shahbazi ABSTRACT Gene regulatory networks and tissue morphogenetic events drive the emergence of shape and function: the pillars of embryo development. Although model systems offer a window into the molecular biology of cell fate and tissue shape, mechanistic studies of our own...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev175059.
Published: 19 June 2020
... in development and evolution, the LPM remains challenging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definition. Here, we outline the processes that govern LPM specification, organization, its cell fates and the inferred evolutionary trajectories of LPM-derived...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175760.
Published: 4 June 2020
... - 192 . 10.1016/S1534-5807(04)00021-8 de la Cova , C. , Townley , R. , Regot , S. and Greenwald , I. ( 2017 ). A real-time biosensor for ERK activity reveals signaling dynamics during C. elegans cell fate specification . Dev. Cell   42 , 542 - 553.e4 . 10.1016/j.devcel...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (5): dev181297.
Published: 2 March 2020
... mechanical and biochemical responses in cells. Below, we discuss how mechanical cues from the lumen can polarize the cytoskeleton and trigger cell migration and proliferation. Next, we evaluate how the lumen can provide signalling cues to guide cell-fate specification and tissue patterning. Finally, we...
Journal Articles
Journal: Development
Development (2019) 146 (20): dev180224.
Published: 23 October 2019
... of basal stem cells is regulated during postnatal prostate development in mouse. Stem cells Prostate development Basal multipotency Cell fate Lineage tracing Mouse The prostate is a glandular organ of the male reproductive system in mammals. It resides around the urethra and underneath...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2019) 146 (20): dev180430.
Published: 18 October 2019
... in mouse Müllerian duct mesenchyme cells caused them to adopt the myofibroblast cell fate, resulting in profound reproductive tract developmental defects and sterility. Myofibroblast differentiation was attributed to increased YAP and TAZ expression (but not to altered WNT signaling), leading to the direct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (18): dev178996.
Published: 19 September 2019
..., and summarised here, were the origins of cell types in the evolution of animal multicellularity, their specialisation in different animal lineages, and the gene regulatory networks (GRNs) that may underlie the specification of various animal cell types. Cell fate Computational analysis Evolution...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev167106.
Published: 16 September 2019
.... the Wnt, Hedgehog and TGFβ pathways), Hippo signalling is a ‘jack of all trades’ that is reiteratively used to mediate a range of cellular decision-making processes from proliferation, death and morphogenesis to cell fate determination. Here, and in the accompanying poster, we briefly outline the core...
Includes: Supplementary data