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Keywords: cell cycle
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Journal Articles
Journal: Development
Development (2022) 149 (17): dev200450.
Published: 30 August 2022
... by a ‘grape’ karyotype, owing to the defects in chromosome alignment. Abnormal alternatively spliced genes related to chromosome segregation, the microtubule cytoskeleton, cell cycle kinases and DNA damage were present in the dhx38 mutants. Subsequently, EMPs and HSPCs in dhx38 mutants underwent P53-dependent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (6): dev199637.
Published: 17 March 2022
...Timothy J. Duerr; Eun Kyung Jeon; Kaylee M. Wells; Antonio Villanueva; Ashley W. Seifert; Catherine D. McCusker; James R. Monaghan ABSTRACT Regulation of cell cycle progression is essential for cell proliferation during regeneration following injury. After appendage amputation, the axolotl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200275.
Published: 18 February 2022
... daughters where it transactivates Notch in neuroblasts. Over time, in response to intrinsic temporal cues and increasing numbers of Delta-expressing daughters, neuroblast Notch activity increases, leading to cell cycle exit and consequently, attenuation of Notch pathway activity. Quiescent neuroblasts have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199710.
Published: 17 February 2022
... to map ERK dynamics across the cell cycle were about 12.5 times longer and had a sampling rate reduced to about 1/5 compared with the short-term recordings ( Fig. S13 ). These qualitative differences of these data prompted for a different analysis strategy. Due to this limited time resolution, we decided...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (20): dev199591.
Published: 19 October 2021
... spliceosome in the developing mouse pallium, causing microcephaly. There, cell cycle defects and p53-mediated apoptosis in response to DNA damage resulted in loss of radial glial cells (RGCs), underpinning microcephaly. Here, we ablated Trp53 to block cell death in Rnu11 cKO mice. We report that Trp53...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2021) 148 (18): dev199919.
Published: 27 September 2021
... attributed. Summary: Discrete roles for cell polarity and the polarity protein BASL before and after asymmetric divisions are revealed through quantitative imaging and lineage tracking of plants expressing BASL at restricted points in the cell cycle. Stomata Asymmetric cell division Cell...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (14): dev199453.
Published: 15 July 2021
... follicular development. However, the mechanisms involved in controlling GC cell cycle are not fully understood. Here, by performing gene expression profiling in the domestic pig ( Sus scrofa ), we showed that cell cycle arrest at G0/G1 phase is highly correlated with pathways associated with hypoxic stress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev193128.
Published: 24 June 2021
...Susanna E. Brantley; Stefano Di Talia ABSTRACT Understanding the mechanisms of embryonic cell cycles is a central goal of developmental biology, as the regulation of the cell cycle must be closely coordinated with other events during early embryogenesis. Quantitative imaging approaches have...
Journal Articles
Journal: Development
Development (2021) 148 (9): dev195552.
Published: 29 April 2021
.... and Niehrs , C. ( 2009 ). Cell cycle control of Wnt receptor activation . Dev. Cell 17 , 788 - 799 . 10.1016/j.devcel.2009.11.006 Dessaud , E. , Yang , L. L. , Hill , K. , Cox , B. , Ulloa , F. , Ribeiro , A. , Mynett , A. , Novitch , B. G. and Briscoe...
Journal Articles
Journal: Development
Development (2021) 148 (8): dev198838.
Published: 16 April 2021
.... However, the functional mechanism of Arid1a in the fate commitment of mesenchymal stem cells (MSCs) and their progeny is not clear. Using the continuously growing adult mouse incisor model, we show that Arid1a maintains tissue homeostasis through limiting proliferation, promoting cell cycle exit...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (3): dev165084.
Published: 8 February 2021
...Noelia Urbán; Tom H. Cheung ABSTRACT Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for life-long tissue homeostasis and regenerative capacity. Quiescence has...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev189712.
Published: 24 July 2020
... of the cell cycle. These combined effects partner to establish and sustain a pool of rapidly proliferating radial glial progenitors in vitro . We also show that, in conditions of variable proliferation dynamics, the branching process tool outperforms other commonly used methods based on thymidine analogs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180273.
Published: 6 November 2019
..., and thereafter balancing SSC renewal versus terminal differentiation. Here, we report that precise regulation of the cell cycle is crucial for this balance. Whereas cyclin-dependent kinase 2 ( Cdk2 ) is not necessary for mouse viability or gametogenesis stages prior to meiotic prophase I, mice bearing...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (20): dev178871.
Published: 24 October 2019
... proliferation is drastically reduced, but resumes when food becomes available. Here, we investigate how neural progenitors halt cell division in response to nutrient restriction and subsequently re-enter the cell cycle upon feeding. We demonstrate that nutrient restriction causes neural progenitors to arrest...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (20): dev177550.
Published: 10 October 2019
... for SHH-driven medulloblastoma. GSK-3 WNT Cerebellar development Medulloblastoma Cell cycle Postnatal neurogenesis Mouse Strict control of progenitor proliferation and differentiation are required for brain growth. Inadequate proliferation causes microcephaly whereas excessive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev177402.
Published: 4 October 2019
...Sudarshan Chari; Henry Wilky; Jayalakshmi Govindan; Amanda A. Amodeo ABSTRACT The early embryos of many animals, including flies, fish and frogs, have unusually rapid cell cycles and delayed onset of transcription. These divisions are dependent on maternally supplied RNAs and proteins including...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev174706.
Published: 15 August 2019
... and discusses new insights into their role in the pathogenesis of solid cancers. Cell cycle Embryogenesis Epigenetic modification of chromatin MEIS PBX Post-transcriptional and posttranslational control Solid cancer Ever since their discovery, MEIS (myeloid ectopic viral integration site...
Journal Articles
Journal: Development
Development (2019) 146 (12): dev173476.
Published: 14 June 2019
... by single cell RNA-seq and identified cell cycle gene expression as a major determinant of transcriptional variation. Within cell cycle stage-matched CMs from a given heart chamber, we found that CMs in the G2/M phase downregulated sarcomeric and cytoskeletal markers. We also identified cell location...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev173195.
Published: 23 April 2019
..., animals displayed fewer stem cells and a slower cell cycle, which combine to substantially decrease progenitor zone output. The C. elegans germline is the only adult tissue that contains stem cells, allowing the analysis of stem cells in aging. To investigate the mechanism of the decrease in stem cell...
Includes: Supplementary data
Journal Articles
In collection:
Plant development
Journal: Development
Development (2019) 146 (3): dev171066.
Published: 4 February 2019
... SPEECHLESS, a pair of genes, SOL1 and SOL2 , are required for effective transitions in the lineage. We show that these two genes, which are homologs of the LIN54 DNA-binding components of the mammalian DREAM complex, are expressed in a cell cycle-dependent manner and regulate cell fate and division...
Includes: Supplementary data