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Keywords: cell cycle
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Journal Articles
Journal: Development
Development (2023) 150 (22): dev202187.
Published: 13 November 2023
... production in invertebrates, where the final topology is typically invariant within each species, we devised a mathematical model for generating cell networks, in which each node is an oscillator and, after a full cycle, the node produces a daughter to which it remains connected. These cell cycle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (14): dev201515.
Published: 18 July 2023
... of the mitotic spindle in vitro in human cells and in vivo in Xenopus . Investigation of CHD2 provides evidence that mutations present in individuals with ASD cause a range of microtubule-related phenotypes, including disrupted localization of the protein at mitotic spindles, cell cycle stalling, DNA damage...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (5): dev201405.
Published: 9 March 2023
... at the shoot apex and root tip. As TSO1 and MYB3R1 are homologous to components of an animal cell cycle regulatory complex, DREAM, Arabidopsis mutants of TSO1 and MYB3R1 provide valuable tools for investigations into the link between cell cycle regulation and stem cell maintenance in plants. In this study...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2023) 150 (4): dev201227.
Published: 24 February 2023
... of the ventral telencephalic marker COUPTFII, with increased variability in these properties. Cell cycle analysis revealed an increase in total cell cycle length caused primarily by an elongated G1 phase, the duration of which also varied more than normal. At later stages, deletion organoids increased their NEUN...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (4): dev200275.
Published: 18 February 2022
... daughters where it transactivates Notch in neuroblasts. Over time, in response to intrinsic temporal cues and increasing numbers of Delta-expressing daughters, neuroblast Notch activity increases, leading to cell cycle exit and consequently, attenuation of Notch pathway activity. Quiescent neuroblasts have...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (4): dev199710.
Published: 17 February 2022
... unseen signaling dynamics in single pluripotent cells, which alternate between oscillatory and non-oscillatory ERK activity. ERK dynamics change with ligand concentration, cell cycle and differentiation state. FGF/ERK signaling Cell cycle Mouse embryonic stem cells Oscillations Signal...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2021) 148 (20): dev199591.
Published: 19 October 2021
... spliceosome in the developing mouse pallium, causing microcephaly. There, cell cycle defects and p53-mediated apoptosis in response to DNA damage resulted in loss of radial glial cells (RGCs), underpinning microcephaly. Here, we ablated Trp53 to block cell death in Rnu11 cKO mice. We report that Trp53...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2021) 148 (14): dev199453.
Published: 15 July 2021
... follicular development. However, the mechanisms involved in controlling GC cell cycle are not fully understood. Here, by performing gene expression profiling in the domestic pig ( Sus scrofa ), we showed that cell cycle arrest at G0/G1 phase is highly correlated with pathways associated with hypoxic stress...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (13): dev193128.
Published: 24 June 2021
...Susanna E. Brantley; Stefano Di Talia ABSTRACT Understanding the mechanisms of embryonic cell cycles is a central goal of developmental biology, as the regulation of the cell cycle must be closely coordinated with other events during early embryogenesis. Quantitative imaging approaches have...
Journal Articles
Journal: Development
Development (2021) 148 (9): dev195552.
Published: 29 April 2021
... Summary: This Review synthesizes current understanding of Hedgehog signal transduction, ligand secretion and transport, and cilia dynamics to explore the temporal and spatial constraints imposed by the primary cilium on Hedgehog signaling in vivo . Hedgehog Cell cycle Cilia Signaling...
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (3): dev165084.
Published: 8 February 2021
...Noelia Urbán; Tom H. Cheung ABSTRACT Quiescence is a cellular state in which a cell remains out of the cell cycle but retains the capacity to divide. The unique ability of adult stem cells to maintain quiescence is crucial for life-long tissue homeostasis and regenerative capacity. Quiescence has...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev189712.
Published: 24 July 2020
... of the cell cycle. These combined effects partner to establish and sustain a pool of rapidly proliferating radial glial progenitors in vitro . We also show that, in conditions of variable proliferation dynamics, the branching process tool outperforms other commonly used methods based on thymidine analogs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (21): dev180273.
Published: 6 November 2019
..., and thereafter balancing SSC renewal versus terminal differentiation. Here, we report that precise regulation of the cell cycle is crucial for this balance. Whereas cyclin-dependent kinase 2 ( Cdk2 ) is not necessary for mouse viability or gametogenesis stages prior to meiotic prophase I, mice bearing...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (20): dev178871.
Published: 24 October 2019
... proliferation is drastically reduced, but resumes when food becomes available. Here, we investigate how neural progenitors halt cell division in response to nutrient restriction and subsequently re-enter the cell cycle upon feeding. We demonstrate that nutrient restriction causes neural progenitors to arrest...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2019) 146 (20): dev177550.
Published: 10 October 2019
... and sustained cell cycle progression in mammalian neuronal precursors . Mol. Cell. Biol.   20 , 9055 - 9067 . 10.1128/MCB.20.23.9055-9067.2000 Kenney , A. M. , Cole , M. D. and Rowitch , D. H. ( 2003 ). Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing...
Includes: Supplementary data