..., transcription of the egl-1 /BH3-only gene promotes cell-specific death. The EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in the release of the caspase activator CED-4/Apaf-1. Subsequent activation of the CED-3 caspase by CED-4 leads to cell death. Despite the important role of egl-1 transcription...

.... elegans nematode neuron serotonin ces-1 ces-2 ced-3 ced-4 During the development of both vertebrates and invertebrates, many cells are bom that neither divide nor form part of the adult, but instead die ( Saunders, 1966 ; Cowan et al . 1984 ; Truman, 1984 ). Programmed cell...