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Development (2007) 134 (7): 1357–1368.
Published: 1 April 2007
..., transcription of the egl-1 /BH3-only gene promotes cell-specific death. The EGL-1 protein inhibits the CED-9/Bcl-2 protein, resulting in the release of the caspase activator CED-4/Apaf-1. Subsequent activation of the CED-3 caspase by CED-4 leads to cell death. Despite the important role of egl-1 transcription...
Includes: Supplementary data
Development (1991) 112 (2): 591–603.
Published: 1 June 1991
.... elegans nematode neuron serotonin ces-1 ces-2 ced-3 ced-4 During the development of both vertebrates and invertebrates, many cells are bom that neither divide nor form part of the adult, but instead die ( Saunders, 1966 ; Cowan et al . 1984 ; Truman, 1984 ). Programmed cell...