... and represses the expression of neuronal differentiation genes. Proneural genes bHLH transcription factors Neurogenins Neocortex Neurogenesis Time is an important axis of developmental information in the neocortex; progenitor cells undergo precise temporal identity transitions that define...

...Jeff Cai; Ying Chen; Wen-Hui Cai; Edward C. Hurlock; Heng Wu; Steven G. Kernie; Luis F. Parada; Q. Richard Lu The mechanisms underlying astrocyte heterogeneity in the developing mouse brain are poorly understood. The bHLH transcription factor Olig2 is essential for motoneuron and oligodendrocyte...

..., Zfp488 can interact and cooperate with the bHLH transcription factor Olig2 to promote precocious and ectopic oligodendrocyte differentiation. Furthermore, knockdown of Zfp488 via RNAi in an oligodendroglial cell line leads to the downregulation of myelin gene expression. Taken together, these data...

... and DNA are shown. Note the residues conserved between all Class II bHLH factors provide these interfaces (red). The residues unique to each sub-family (blue) provide surfaces for additional interactions. Neural bHLH transcription factors play essential roles in nervous system development...

...@utsouthwestern.edu ) 30 1 2003 © 2003. 2003 bHLH transcription factors Transcriptional regulation Transcription repressors Chick electroporation Dorsal spinal cord development Neuronal differentiation Math1/Cath1 Mash1/Cash1 Ngn1 Ngn2 The differentiation of a proliferating neural...