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Keywords: bHLH
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Journal Articles
Journal: Development
Development (2020) 147 (12): dev184093.
Published: 22 June 2020
... of inhibitor of differentiation (Id) factors. We have previously identified the major binding partner of Id proteins in pluripotent cells as the basic helix-loop-helix (bHLH) transcription factor (TF) E2A. Id1 can prevent E2A from forming heterodimers with bHLH TFs or from forming homodimers. Here, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2480–2489.
Published: 1 July 2017
... in the expression of Irx3 , Irx5 , Gli3 and Alx4 , all of which are upregulated in Hand2 limb conditional knockouts. A reduction of Hand2 and Shh gene dosage improves the integrity of anterior limb structures, validating the importance of the Twist-family bHLH dimer pool in limb morphogenesis. * Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (15): 3050–3061.
Published: 1 August 2014
... by alterations in Fgf8 and Shh pathway expression. Together, our data indicate that the extreme distal pharyngeal arch expression domain of Hand1 defines a novel bHLH-dependent activity, and that disruption of established Hand1 dimer phosphoregulation within this domain disrupts normal craniofacial patterning...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2249–2259.
Published: 1 June 2011
... expansion, from which the tongue arises, resulting in aglossia. Hand2 thus appears to establish a distal mandibular arch domain that is conducive for lower jaw development, including the initiation of tongue mesenchyme morphogenesis. © 2011. 2011 Aglossia bHLH Craniofacial Hinge and caps...
Journal Articles
Journal: Development
Development (2011) 138 (11): 2171–2183.
Published: 1 June 2011
... genes act together to control H-cell gene expression. The l(1)sc bHLH gene is required for all H-cell-specific gene transcription, whereas tailup acts in parallel to l(1)sc and controls genes involved in dopamine metabolism. SoxNeuro functions downstream of l(1)sc and controls expression of a peptide...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2265–2276.
Published: 1 July 2009
... been described in some detail for one dicot species, Arabidopsis , in which three paralogous bHLH transcription factors, FAMA, MUTE and SPCH, control discrete sequential stages in stomatal development. Orthologs of FAMA, MUTE and SPCH are present in other flowering plants. This observation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 933–942.
Published: 15 March 2009
...Ning Liu; Ana C. Barbosa; Shelby L. Chapman; Svetlana Bezprozvannaya; Xiaoxia Qi; James A. Richardson; Hiromi Yanagisawa; Eric N. Olson The basic helix-loop-helix (bHLH) transcription factor Hand2 is required for growth and development of the heart, branchial arches and limb buds. To determine...
Journal Articles
Journal: Development
Development (2008) 135 (11): 2031–2041.
Published: 1 June 2008
... Cedex 13, France 3 4 2008 © 2008. 2008 bHLH Proneural Dentate gyrus Hippocampus Mouse The dentate gyrus (DG) is, with the olfactory bulb, one of two regions of the mammalian brain where new neurons are added to existing neural circuits throughout adulthood ( Altman,1962...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (24): 4405–4415.
Published: 15 December 2007
... the neurogenic epithelium of the developing inner ear into specialized mechanosensory receptors. By Cre-loxP fate mapping, we show that vestibular sensory hair cells derive from a previously neurogenic region of the inner ear. The related bHLH genes Ngn1 ( Neurog1 ) and Math1 ( Atoh1 ) are required, respectively...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1755–1765.
Published: 1 May 2007
... site, (C) MEIS1 site, (D) FP3 site, (E)second DLX/MSX/NKX2.5 site, (F) MASH1 site, and (G) FP6 site. Scale bar: 500 μm. Fig. 7. The bHLH transcription factor MASH1 can bind and activate transcription through an E-box sequence in the I12b enhancer. ( A ) In a transient co-transfection assay...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (24): 4815–4825.
Published: 15 December 2006
..., how these subtypes arise remains largely unknown at the molecular level. Here, we demonstrate that the expression of Bhlhb5, a bHLH transcription factor of the Olig family, is tightly associated with the generation of selective GABAergic amacrine and Type 2 OFF-cone bipolar subtypes throughout...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (20): 4097–4108.
Published: 15 October 2006
... interacts with a subset of proneural bHLH proteins. † Authors for correspondence (e-mail: muriel.perron@ibaic.u-psud.fr and tpieler@gwdg.de ) * These authors contributed equally to this work 4 8 2006 © 2006. 2006 bHLH Hes2 Gliogenesis Neurogenesis Retina Cell cycle...
Journal Articles
Journal: Development
Development (2006) 133 (13): 2467–2476.
Published: 1 July 2006
... and acting as organizing centers. We now report that in mice the bHLH factor Hes1 is persistently expressed at high levels by boundary cells but at variable levels by non-boundary cells. Expression levels of Hes1 display an inverse correlation to those of the proneural bHLH factor Mash1, suggesting...
Journal Articles
Journal: Development
Development (2005) 132 (16): 3619–3630.
Published: 15 August 2005
...Elise Lamar; Chris Kintner The HES family of bHLH repressors plays a key role in regulating the differentiation of neural precursors in the vertebrate embryo. Members of the HES gene family are expressed in neural precursors as targets of the Notch signaling pathway, but how this occurs...
Journal Articles
Journal: Development
Development (2005) 132 (12): 2709–2719.
Published: 15 June 2005
... populations (dI1-dI6) have been defined by expression of homeodomain factors and position in the dorsoventral axis. The bHLH transcription factors Mash1 and Ngn2 have distinct roles in specification of these neurons. Mash1 is necessary and sufficient for generation of most dI3 and all dI5 neurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (22): 5539–5550.
Published: 15 November 2004
.... Hatakeyama, J., Tomita, K., Inoue, T. and Kageyama, R. ( 2001 ). Roles of homeobox and bHLH genes in specification of a retinal cell type. Development 128 , 1313 -1322. Hatta, K. and Takeichi, M. ( 1986 ). Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick...
Journal Articles
Journal: Development
Development (2004) 131 (10): 2359–2372.
Published: 15 May 2004
...Alexis Tapanes-Castillo; Mary K. Baylies One of the first steps in embryonic mesodermal differentiation is allocation of cells to particular tissue fates. In Drosophila , this process of mesodermal subdivision requires regulation of the bHLH transcription factor Twist. During subdivision, Twist...
Journal Articles
Journal: Development
Development (2004) 131 (9): 2195–2204.
Published: 1 May 2004
...Yuka Morikawa; Peter Cserjesi The basic helix-loop-helix (bHLH) transcription factor HAND1 (also called eHAND) is expressed in numerous tissues during development including the heart, limbs, neural crest derivatives and extra-embryonic membranes. To investigate the role of Hand1 during development...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1679–1689.
Published: 15 April 2004
... process of neural precursor cell (NPC) selection by basic helix-loop-helix (bHLH) proneural transcription factors in the peripheral nervous system (PNS) by atonal related proteins (ARPs) presents an excellent model in which to address this issue. Proneural ARPs belong to two highly related groups...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6507–6518.
Published: 29 December 2003
...C. Andrew Frank; Paul D. Baum; Gian Garriga Achaete-Scute basic helix-loop-helix (bHLH) proteins promote neurogenesis during metazoan development. In this study, we characterize a C. elegans Achaete-Scute homolog, HLH-14. We find that a number of neuroblasts express HLH-14 in the C. elegans embryo...