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Keywords: apoptosis
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Journal Articles
Journal: Development
Development (2024) 151 (1): dev202407.
Published: 4 January 2024
... Müller glial cells and with microglia during the clearance of apoptotic cells. Müller glia Phagocytosis Microglia Intercellular transfer Time-lapse recordings Apoptosis Zebrafish National Eye Institute http://dx.doi.org/10.13039/100000053 R01 EY030467 University...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (19): dev201167.
Published: 6 October 2023
...Jimei Xu; Yanwen Jiang; Ryan Sherrard; Kyoko Ikegami; Barbara Conradt ABSTRACT During C. elegans development, 1090 somatic cells are generated, of which 959 survive and 131 die, many through apoptosis. We present evidence that PUF-8, a C. elegans ortholog of the mammalian RNA-binding proteins PUM1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (5): dev201231.
Published: 9 March 2023
... apical cell extrusion in the head initiates a cascade of apical extrusions of apoptotic and non-apoptotic cells that sweeps the entire ventral body wall. Here, we show that this process is apoptosis dependent, and clustered apoptosis, groove formation, and wounding sensitize EGFR mutant epithelia...
Includes: Supplementary data
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Reproductive biology
Journal: Development
Development (2021) 148 (24): dev199762.
Published: 15 December 2021
... independently of Netrin to directly regulate transcription during axon guidance in Drosophila . In other contexts, Dcc acts as a tumor suppressor by directly promoting apoptosis. In this study, we report that Fra is required in the Drosophila female germline for the progression of egg chambers through mid...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (14): dev191882.
Published: 24 July 2020
... autonomously ( Bass et al., 2009 ; Peterson and McCall, 2013 ). Although release of mitochondrial proteins can lead to caspase activation and apoptosis, mitochondria may also direct alternative cell dismantling. Mitochondrial HtrA2 can promote germ-cell death in Drosophila independently of caspases...
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (13): dev184838.
Published: 3 July 2020
... that is suppressed by Hx. Interestingly, GCs with lower expression of GDF9/BMP15 receptors appear to be more sensitive to Hx-induced G2/M arrest and become easily detached from the follicular wall. Importantly, Hx-mediated inhibition of G2/M progression instigates GC apoptosis, which is ameliorated in the presence...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2020) 147 (1): dev182295.
Published: 13 January 2020
... analysis implicates p53 signaling; moreover, p53 ablation in Magoh haploinsufficient progenitors rescues apoptosis, completely recovering interneuron number. In striking contrast, in Magoh homozygotes, p53 loss fails to rescue interneuron number and mitotic delay, further implicating mitotic defects...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (20): dev164046.
Published: 24 October 2018
... kinase (LTK), an ALK-type receptor tyrosine kinase, is expressed by neural crest cells during early migratory stages in chicken embryos. Loss of LTK in the cranial neural crest impairs migration and results in increased levels of apoptosis. Conversely, midkine, previously proposed as a ligand for ALK...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev160127.
Published: 11 June 2018
... intermediate neural progenitors (INPs). Distinct type II neuroblasts produce different characteristic sets of glia. A single INP can make both astrocyte-like and ensheathing glia, which co-occupy a relatively restrictive subdomain. Blocking apoptosis uncovers further lineage distinctions in the specification...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev158139.
Published: 8 January 2018
...% of immature thymocytes are eliminated via apoptosis. It is known that mutation of Zeb1 , one of the retinoblastoma 1 (Rb1) target genes, results in a decrease in the number of immature T cells in mice. E2F1, an RB1-interacting protein, has been shown to regulate mature T cell development by interfering...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154468.
Published: 3 January 2018
... and undergo apoptosis, thereby disrupting endocrine and acinar cell differentiation, resulting in pancreatic agenesis. Rescue experiments implicate the Asna1 ATPase activity and a CXXC di-cysteine motif in ensuring Golgi integrity, syntaxin 5 localization and MPC survival. Ex vivo inhibition of retrograde...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (20): 3840–3846.
Published: 15 October 2017
... post-acquisition processing. They overcome the limitations of other apoptosis detection methods developed so far and, notably, they can be combined with any kind of fluorophore. References Ambrosini , A. , Gracia , M. , Proag , A. , Rayer , M. , Monier , B. and Suzanne , M...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3602–3611.
Published: 1 October 2017
... neural progenitors. Live imaging and immunolocalizations indicate that Sp-SoxC-expressing cells divide to produce pairs of adjacent cells expressing GFP. Over an interval of about 6 h, one cell fragments, undergoes apoptosis and expresses high levels of activated Caspase3. A Notch reporter indicates...
Includes: Supplementary data