.... They differed in their diameter, flow magnitude and marker gene expression. At later stages, intussusceptive angiogenesis occurred from veins in distal fin regions. In proximal fin regions, we observed new vein sprouts crossing the inter-ray tissue through sprouting angiogenesis. Together, our results reveal...

... Wt1 expression is deleted in ECs reveals the crucial role of WT1 in coronary blood vessel development. WT1 Heart development Coronary endothelial cells Blood vessel formation Angiogenesis Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837...

... defects in the expression of endothelial junctional proteins as well as aberrant adhesion between astrocytes and laminins in vascular basement membranes, resulting in pathological blood–brain barrier integrity. Angiogenesis Extracellular matrix Brain microenvironment Blood vessel Vascular smooth...

... play an important role in directing polarized endothelial migration through integrin signaling during angiogenesis ( Park et al., 2019 ; Ruiz de Almodovar et al., 2010 ; Zovein et al., 2010 ). Loss or accumulation of ECM proteins could, respectively, suppress or enhance endothelial migration...

...Diane L. Gumina; Shuhan Ji; Amanda Flockton; Kathryn McPeak; Dominik Stich; Radu Moldovan; Emily J. Su ABSTRACT Placentas from pregnancies complicated by severe early-onset fetal growth restriction (FGR) exhibit diminished vascular development mediated by impaired angiogenesis, but underlying...

... in retinal progenitor cells did not affect initial progression of retinal angiogenesis, but it disrupted the pruning of blood vessels and establishment of arterioles and venules. In the absence of retinal HS, blood vessels were also vulnerable to high oxygen tension in early postnatal stages, which could...

..., stabilisation and maintenance of blood vessel connections remain poorly defined. Here, we identify blood flow and the large extracellular protein Svep1 as co-modulators of vessel anastomosis during developmental angiogenesis in zebrafish embryos. Both loss of Svep1 and blood flow reduction contribute...

...Arpan De; John E. Morales; Zhihua Chen; Sumod Sebastian; Joseph H. McCarty ABSTRACT In the developing mammalian brain, neuroepithelial cells interact with blood vessels to regulate angiogenesis, blood-brain barrier maturation and other key neurovascular functions. Genetic studies in mice have shown...

... or regional zebrafish brain vasculature, called zebrafish vasculature quantification or ZVQ. Angiogenesis LSFM Registration Quantification Vasculature University of Sheffield http://dx.doi.org/10.13039/501100000858 University of Sheffield http://dx.doi.org/10.13039...

...Françoise Helmbacher ABSTRACT Angiogenesis is a stepwise process leading to blood vessel formation. In the vertebrate retina, endothelial cells are guided by astrocytes migrating along the inner surface, and the two processes are coupled by a tightly regulated cross-talks between the two cell types...

... is important for activating genes during development and for histone H3 lysine 14 acetylation (H3K14ac). Loss of HBO1 and H3K14ac impaired developmental sprouting angiogenesis and reduced pathological EC overgrowth in the retinal endothelium. Single-cell RNA sequencing of retinal ECs revealed an increased...

... mutants in zebrafish embryos reveals distinct functions of Rasip1 during sprouting angiogenesis, anastomosis and lumen formation. During angiogenic sprouting, loss of Rasip1 causes cell pairing defects due to a destabilization of tricellular junctions, indicating that stable tricellular junctions...

... angiogenesis and neurovascular barrier maturation have been elucidated in recent years. Yet how neuronal activity influences these processes remains largely unexplored. Here, we discuss our current understanding of how neuronal and glial development affects CNS angiogenesis and barriergenesis, and outline...

...Lilian Schimmel; Daisuke Fukuhara; Mark Richards; Yi Jin; Patricia Essebier; Emmanuelle Frampton; Marie Hedlund; Elisabetta Dejana; Lena Claesson-Welsh; Emma Gordon ABSTRACT Endothelial cell adhesion is implicated in blood vessel sprout formation, yet how adhesion controls angiogenesis, and whether...

... that the original work is properly attributed. Highlighted Article: A stepwise dual mechanism involving Notch signalling and flow provides the adaptability required to establish a balanced network of arteries and veins in the zebrafish trunk. Notch Angiogenesis Artery Developmental patterning...

..., developmental vascular pruning may be viewed as a mutual feedback mechanism between the nascent microvascular plexus and the associated astrocytes. Rising oxygen levels accompanying retinal angiogenesis may limit the expansion of the astrocytic population by driving maturation differentiation, thus forcing...

... that Cdc42 controls EC axial polarity, at least in part, through localization of the Par complex. Sprout extension, shuffling of tip cells, branch anastomosis and regression collectively shape the growing vascular network during angiogenesis. These processes require cytoskeletal rearrangement and EC...

... disease. In development, the influence of neuroprogenitor cells on angiogenesis is poorly understood. Here, we show in mouse that these cells interact intimately with the growing retinal vascular network, and we identify a novel regulatory mechanism of vasculature development mediated by hypoxia-inducible...

.... Wilson; Joshua D. Wythe The transcriptional pathways activated downstream of vascular endothelial growth factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find...

... http://www.biologists.com/user-licence-1-1/ Highlighted article: Proper organization of the placental labyrinth in mice depends on coordinated inter-endothelial repulsion mediated by the binding of FLRT2 to the UNC5B receptor. Angiogenesis Placenta Neurovascular FLRT2 UNC5B...