...Izumi Oda-Ishii; Deli Yu; Yutaka Satou ABSTRACT Zic-r.a, a maternal transcription factor, specifies posterior fate in ascidian embryos. However, its direct target, Tbx6-r.b , does not contain typical Zic-r.a-binding sites in its regulatory region. Using an in vitro selection assay, we found...

... regulatory factors, Zic-r.b, Tbx6-r.b and Mrf, and elucidate the mechanism by which these factors activate muscle structural genes. We reveal a cross-regulatory circuit among these regulatory factors, which maintains the expression of Tbx6-r.b and Mrf during gastrulation. Although these two factors...

... switch at the 32-cell stage. Namely, in marginal cells where nβ-catenin is absent, Gata.a directly activates its target, Zic-r.b ( ZicL ), to specify the marginal cell lineages. Thus, the antagonistic action between nβ-catenin and Gata.a is involved in two consecutive stages of germ layer segregation...

.... Published by The Company of Biologists Ltd 2013 Dorsoventral patterning Modularity Somite Zic Oryzias latipes Vertebrates display diverse morphology and coloration, especially on the dorsal side. For example, many of reptiles and fish have crests or fins on the midline...

... s-hc ) that specifically disrupts expression in the lateral peripodial epithelium of eye/antennal discs and is required for ventral head formation. Here we describe the recovery of mutations in odd-paired ( opa ), a zinc finger transcription factor related to the vertebrate Zic family, as dominant...

... Zic Wnt Proliferation Tectum Zebrafish In the developing embryo, cells acquire distinct positional identities, or pattern, while simultaneously undergoing rapid division. Precise coordination of pattern formation and proliferation is clearly essential for normal embryogenesis, yet...

... Runx Hox Zic Segmentation sloppy paired 1 engrailed wingless Drosophila Extensive genetic and molecular studies have elucidated the major principles of the pathway that generates the segmented body plan of the Drosophila embryo. Broad gradients of maternal information...

... regulation of neural differentiation in Hydra is largely unknown. Here, we report the identification of Hyzic , a homolog of the Zn-finger transcription factor gene zic/odd-paired , which acts as an early neural effector gene in vertebrates. We show, that Hyzic is expressed in the early nematocyte...

... aired -like) that resembles the Drosophila pair-rule gene odd-paired and encodes a zinc finger protein that is a member of the Zic gene family. At the onset of gastrulation, opl is expressed throughout the presumptive neural plate, indicating that neural determination has begun at this stage while...

...Kenji Mizuseki; Masashi Kishi; Masaru Matsui; Shigetada Nakanishi; Yoshiki Sasai ABSTRACT In a differential screen for downstream genes of the neural inducers, we identified two extremely early neural genes induced by Chordin and suppressed by BMP-4: Zic-related-1 (Zic-r1), a zinc finger factor...