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Keywords: Yorkie
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Journal Articles
Journal: Development
Development (2021) 148 (14): dev198705.
Published: 27 July 2021
... in humans, ensure robust morphogenesis by suppressing JNK-mediated apoptosis via Yorkie in Drosophila . Tissue growth Cell death Yorkie Ribosomal protein mutant Ministry of Education, Culture, Sports, Science and Technology http://dx.doi.org/10.13039/501100001700 19K22424 20H05945...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev190124.
Published: 17 November 2020
.... However, the molecular mechanisms of Drosophila epithelial cell extrusion are not fully understood. Here, we report that activation of the conserved Hippo (Hpo) signaling pathway induces both apical and basal cell extrusion in the Drosophila wing disc epithelia. We show that canonical Yorkie targets Diap1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev179069.
Published: 27 April 2020
... transcriptional co-activators Yorkie, YAP and TAZ is far more dynamic than previously appreciated, and YAP and TAZ are also regulated by liquid-liquid phase separation. Here, we review our current understanding of Yorkie, YAP and TAZ regulation, with a focus on recent microscopy-based studies...
Journal Articles
Journal: Development
Development (2019) 146 (15): dev173005.
Published: 2 August 2019
... Drosophila epithelium causes cells to enter the endocycle through the activation of Yorkie-dependent genes ( Myc and E2f1 ). Myc is even sufficient to induce the endocycle in the uninjured post-mitotic epithelium. As result, epithelial cells enter S phase but mitosis is blocked by inhibition of mitotic gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev165712.
Published: 17 October 2018
... of the Hippo signaling transcriptional activator Yorkie gradually decreases in the central region of the developing Drosophila wing disc. Spatial and temporal changes in Yorkie activity can be explained by changes in cytoskeletal tension and biomechanical regulators of Hippo signaling. These changes...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (5): dev159467.
Published: 8 March 2018
... of which is named Yorkie (Yki). In mammalian cells in culture, artificial mechanical forces induce nuclear translocation of YAP and TAZ. Here, we show that physiological mechanical strain can also drive nuclear localisation of Yki and activation of Yki target genes in the Drosophila follicular epithelium...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (14): 2584–2594.
Published: 15 July 2017
... integration involves escort cells (ECs), which promote differentiation of the GSC derivatives they envelop, provide niche signals for FSCs and derive directly from FSCs in adults. Hedgehog (Hh) signaling induces the Hippo pathway effector Yorkie (Yki) to promote proliferation and maintenance of FSCs, but Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (8): 1470–1479.
Published: 15 April 2015
...Catarina Brás-Pereira; Fernando Casares; Florence Janody The Drosophila transcriptional co-activator protein Yorkie and its vertebrate orthologs YAP and TAZ are potent oncogenes, whose activity is normally kept in check by the upstream Hippo kinase module. Upon its translocation into the nucleus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (6): 1197–1208.
Published: 15 March 2014
... modulated remains relatively unknown. Here we show that planarians use the downstream effector of the Hippo signaling cascade, yorkie ( yki ; YAP in vertebrates) to control a diverse set of pleiotropic processes in organ homeostasis, stem cell regulation, regeneration and axial patterning. We show that yki...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1498–1508.
Published: 15 April 2012
...Hitoshi Matakatsu; Seth S. Blair The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP). Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki). Much of Ft activity is likely to be mediated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (14): 2397–2408.
Published: 15 July 2010
... neuroepithelia. Mutation of tumor suppressor genes within the pathway, or expression of activated Yorkie, promotes overgrowth of neuroepithelial cells and delays or blocks their differentiation; mutation of yorkie inhibits growth and accelerates differentiation. Neuroblasts and other neural cells, by contrast...
Includes: Supplementary data