... in cardiomyocyte cell cycle arrest, we conditionally activated ROCK2 kinase domain (ROCK2:ER) in the murine postnatal heart. Here, we show that α5/β1 integrin and fibronectin matrix increase in response to actomyosin-mediated tension. Moreover, activation of ROCK2:ER promotes nuclear translocation of Yap...

... remain dependent on XAV939. Rather than inhibiting Wnt, we found that XAV939 prevents TE induction by reducing activation of YAP, a co-factor of TE-inducing TEAD transcription factors. Tankyrase inhibition stabilises angiomotin, which limits nuclear accumulation of YAP. Upon deletion of angiomotin-family...

... that VEGF-C signaling is necessary for valve morphogenesis. We have also discovered that the transcriptional co-activators YAP and TAZ are required to maintain PROX1 expression in LVs and LVVs in response to VEGF-C signaling. Deletion of Yap and Taz in the lymphatic vasculature of mouse embryos did...

...Hannah K. Vanyai; Fabrice Prin; Oriane Guillermin; Bishara Marzook; Stefan Boeing; Alexander Howson; Rebecca E. Saunders; Thomas Snoeks; Michael Howell; Timothy J. Mohun; Barry Thompson; Sally Dunwoodie; John Wallingford ABSTRACT The Hippo-YAP/TAZ pathway is an important regulator of tissue growth...

... stimulate RGC self-amplification through the positive post-transcriptional regulation of the Hippo signalling effector YAP. We anticipate this SMAD1/5-YAP signalling module to be fundamental in controlling growth and evolution of the amniote cerebral cortex. References Alarcón , C. , Zaromytidou...

... transcriptional co-activators Yorkie, YAP and TAZ is far more dynamic than previously appreciated, and YAP and TAZ are also regulated by liquid-liquid phase separation. Here, we review our current understanding of Yorkie, YAP and TAZ regulation, with a focus on recent microscopy-based studies. References...

... such as the esophagus. However, the molecular mechanisms regulating these progenitor activities in the esophagus remain to be elucidated. Here, we demonstrated that Yap is required for the proliferation of esophageal progenitor cells (EPCs) in the developing murine esophagus. We found that Yap deficiency reduces EPC...

...John Robert Davis; Nicolas Tapon ABSTRACT The Hippo signalling pathway and its transcriptional co-activator targets Yorkie/YAP/TAZ first came to attention because of their role in tissue growth control. Over the past 15 years, it has become clear that, like other developmental pathways (e.g...

...Benjamin J. van Soldt; Jun Qian; Jiao Li; Nan Tang; Jining Lu; Wellington V. Cardoso ABSTRACT Although the Hippo–yes-associated protein (Yap) pathway has been implicated in lung development, the specific roles for Yap and its nucleocytoplasmic shuttling in the developing airway and alveolar...

... pathway (nuclear Yap) or ablation of Yap result in increased β-catenin and Fgf10 signaling, suggesting a cytoplasmic role for Yap in epithelial lineage commitment. We further demonstrate redundant and non-redundant functions for the two nuclear effectors of the Hippo pathway, Yap and Taz, during lung...

... heart development reveals its role in compact wall maturation and trabeculation, as well as in modulation of the cardiomyocyte actomyosin network and cell-cell junctions. Heart development Hippo pathway Yap Taz Wwtr1 Trabeculation Cardiac trabeculation is an important step to cardiac...

...Zhihui Huang; Jinxia Hu; Jinxiu Pan; Ying Wang; Guoqing Hu; Jiliang Zhou; Lin Mei; Wen-Cheng Xiong ‪YAP (yes-associated protein), a key transcriptional co-factor that is negatively regulated by the Hippo pathway, is crucial for the development and size control of multiple organs, including...

... arteries and cranial vasculature during embryonic development. Neural crest-specific deletion of the Hippo effectors Yap and Taz produces neural crest precursors that migrate normally, but fail to produce vascular smooth muscle, and Notch target genes such as Jagged1 fail to activate normally. We show...

... use a conditional knockout approach to inactivate within the nephric duct (ND) lineage the two effectors of the Hippo pathway, Yap and Taz . Deletion of Yap leads to hydronephrotic kidneys with blind-ending megaureters at birth. In Yap mutants, the ND successfully migrates towards, and contacts...

... modulated remains relatively unknown. Here we show that planarians use the downstream effector of the Hippo signaling cascade, yorkie ( yki ; YAP in vertebrates) to control a diverse set of pleiotropic processes in organ homeostasis, stem cell regulation, regeneration and axial patterning. We show that yki...

.... , Kiyonari H. , Ota M. , Ralston A. , Yabuta N. , Hirahara S. , Stephenson R. O. , Ogonuki N. , et al . ( 2009 ). The hippo signaling pathway components lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass . Dev. Cell 16 , 398...

..., but does not arrest, neuroepithelial cell cycle induces premature neurogenesis . J. Cell Sci. 116 , 4947 - 4955 . Cao X. , Pfaff S. L. , Gage F. H. ( 2008 ). YAP regulates neural progenitor cell number via the TEA domain transcription factor . Genes Dev. 22 , 3320 - 3334...