...Momoko Deguchi; Taro Fukazawa; Takeo Kubo ABSTRACT Xenopus laevis tadpoles can regenerate whole tails after amputation. We have previously reported that interleukin 11 ( il11 ) is required for tail regeneration. In this study, we have screened for genes that support tail regeneration under Il11...

... as Zar1-like), have been described ( Sangiorgio et al., 2008 ; Wu et al., 2003 ; Yamamoto et al., 2013 ). Interestingly, a third, and so far functionally uncharacterized, member of the Zar protein family has been identified in Xenopus laevis. This protein, termed Zar1l (Zar1l.L/XP_018103300.1...

... as an important resource for model organisms, including the frog Xenopus laevis . Xenopus has long been used to study developmental and cell biology, and is an increasingly important model for human birth defects and disease, genomics, proteomics and toxicology. Scientists utilize Nieuwkoop and Faber's classic...

... development via recycling of the crucial cargo ephrinB1. Rab11fip5 EphrinB1 Rab11 Telencephalon Autism-spectrum disorder Xenopus laevis Eph/ephrin signaling regulates multiple biological processes during embryogenesis. Loss-of-function studies have demonstrated the involvement of Eph...

...-metamorphic Xenopus laevis tadpoles to self-correct malformed craniofacial tissues. We found that tadpoles can adaptively improve and normalize abnormal craniofacial morphology caused by numerous developmental perturbations. We then investigated the tissue-level and molecular mechanisms that mediate the self...

.../ Highlighted article: A non-classical function of acetylcholinesterase in the polarization, rearrangement and adhesion of endoderm cells during Xenopus gut morphogenesis is identified. Acetylcholinesterase Morphogenesis Gut Intestine Fibronectin Xenopus laevis Acetylcholinesterase...

... defects, as well as basic evolutionary and developmental biology. However, many studies are conducted on a range of embryonic stages that are not fully represented in the beloved Xenopus resource, Nieuwkoop and Faber's classic Normal Table of Xenopus laevis (Daudin) . The lack of standardized images...

... and bioelectric activities during tail regeneration in Xenopus laevis tadpoles. We show that inhibition of NADPH oxidase-mediated production of ROS, or scavenging or blocking their diffusion into cells, impairs regeneration and consistently regulates the dynamics of membrane potential, transepithelial potential...

... regulator of ciliogenesis. In multiciliated cells of the Xenopus epidermis, Foxn4 promotes high-level expression of Foxj1 targets for efficient generation of multiple cilia. Cilia Foxj1 Foxn4 Multiciliate cells Xenopus laevis The multiciliated cell (MCC) is a specialized epithelial...

... from pluripotent cells. The EFTF Tbx3 can regulate the expression of some EFTFs; however, its role in retina formation is unknown. Here, we show that Tbx3 represses bmp4 transcription and is required in the eye field for both neural induction and normal eye formation in Xenopus laevis . Although...

.... The function of Dg was examined in Xenopus laevis embryos by knockdown of Dg and overexpression and replacement of the endogenous Dg with a mutated form of the protein. This analysis revealed that Dg is required for correct laminin assembly, for cell polarization during mediolateral intercalation...

... through which non-canonical Wnt signaling contributes to tubular development. Using Xenopus laevis as a model system, we found that the cell-adhesion molecule Alcam is required for proper nephrogenesis and functions downstream of Fzd3 during embryonic kidney development. We found alcam expression...

... block in proliferation and differentiation specifically in progenitor but not stem cells, defining a nutrient-sensitive restriction point that operates in the differentiation programme of retinal stem and progenitor cells. We deprived Xenopus laevis larvae of their physiological internal...

... of a Klf4 homologue in Xenopus laevis during embryogenesis. Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation. Klf4 promotes endoderm differentiation in both Nodal/Activin-dependent and -independent manners. Moreover, Klf4 regulates...

... three cytoskeletal polymers to form the axon. Microtubule associated protein tau Actin-related protein 2 α-Internexin Xenopus laevis Control of expression of proteins associated with the cytoskeleton is crucial for meeting changing demands for structural materials as axonal growth shifts...

...), are essential for eukaryotic ribosome biogenesis. In this study, we demonstrate that PPan is expressed maternally as well as in the eye and cranial neural crest cells (NCCs) during early Xenopus laevis development. Depletion of PPan and interference with rRNA processing using antisense morpholino...

..., USA Competing interests statement 6 4 2010 © 2010. Tbx20 Cardiogenesis Cardiac Heart Xenopus laevis Xenopus tropicalis SMAD1 SMAD4 T-box BMP Zebrafish Transgenesis A series of clinical studies has provided direct evidence...

...’ is above the threshold (dashed black line), thereby expanding Wnt signalling by sFRP (yellow arrow, line 5). * Author for correspondence ( m_taira@biol.s.u-tokyo.ac.jp ) 30 9 2009 © 2009. 2009 Xenopus laevis Diffusion Morphogen sFRP Frzb sFRP3 Crescent Wnt8 Wnt11...

...Taro Fukazawa; Yuko Naora; Takekazu Kunieda; Takeo Kubo Regenerative ability varies depending on animal species and developmental stage, but the factors that determine this variability remain unclear. Although Xenopus laevis tadpole tails possess high regenerative ability, this is transiently lost...

... abnormalities associated with xKaiso-depleted Xenopus laevis embryos are independent of the putative CTGCNA-dependent DNA-binding function of xKaiso. Our analysis suggests that xKaiso does not play a role in the regulation of either xWnt11 or Siamois, key signalling molecules in the Wnt pathway during X. laevis...