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Keywords: X inactivation
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Journal Articles
Journal: Development
Development (2023) 150 (22): dev201742.
Published: 22 November 2023
... Summary: This Review discusses the chromatin modifications associated with the mammalian female inactive X chromosome and their relevance to gene silencing and potential for therapeutic modulation. X inactivation Epigenetics Female Gene silencing Stem cells National Health and Medical...
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175141.
Published: 11 June 2020
...Andreas Postlmayr; Charles Etienne Dumeau; Anton Wutz ABSTRACT We previously identified the cyclin dependent kinase Cdk8 as a putative silencing factor for Xist . To investigate its role in X inactivation, we engineered a Cdk8 mutation in mouse embryonic stem cells (ESCs) carrying an inducible...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2015) 142 (21): 3791–3800.
Published: 1 November 2015
... Spermatogenesis Epigenetic regulation X inactivation Male fertility Meiosis During spermatogenesis in a variety of Metazoan species, the sex chromosomes undergo a large-scale chromatin remodeling event unique to male germ cells, termed meiotic sex chromosome inactivation (MSCI) ( Lifschytz...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (7): 1423–1426.
Published: 1 April 2014
... in any medium provided that the original work is properly attributed. Haploid cells ES cells Genetic screening Transgenics Genomic imprinting X inactivation Diploidy (from the Greek word diplous, meaning ‘double’) is a term used to denote the existence of two sets...
Journal Articles
Journal: Development
Development (2011) 138 (23): 5057–5065.
Published: 1 December 2011
... gene silencing. I will discuss observations that challenge the following ideas: that cycles of X inactivation and X reactivation in preimplantation embryos are solely attributable to the modulation of Xist RNA expression; the prevailing view that Xist-mediated silencing is solely attributable...
Journal Articles
Journal Articles
Journal Articles
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Journal Articles
Journal: Development
Development (2009) 136 (4): 525–530.
Published: 15 February 2009
..., London WC2A 3PX, UK † Present address: The Royal Veterinary College, London NW1 0TU, UK 17 12 2008 © 2009. 2009 Long noncoding RNA Imprinting X inactivation Epigenetic gene silencing Kcnq1ot1 Noncoding RNAs (ncRNAs) have key roles in the regulation of complex...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 227–235.
Published: 15 January 2008
...Tatsuya Ohhata; Yuko Hoki; Hiroyuki Sasaki; Takashi Sado Expression of Xist , which triggers X inactivation, is negatively regulated in cis by an antisense gene, Tsix , transcribed along the entire Xist gene. We recently demonstrated that Tsix silences Xist through modification of the chromatin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1990) 108 (Supplement): 47–54.
Published: 1 April 1990
...) -either improper imprinting or improper erasure could lead to unusual patterns of inheritance (as in the fragile-X syndrome) or fitness effects skipping generations. Copyright © 1990 by Company of Biologists 1990 X inactivation mealybugs evolution of sex anisogamy By imprinting we...