... with their in vitro culture have resulted in an under-representation of female mESCs in the literature. Recent studies show that the second X chromosome in female, and more specifically the transcriptional activity from both of these chromosomes due to absent X chromosome inactivation, sets female and male mESCs...

....0408021101 Chaumeil , J. , Waters , P. D. , Koina , E. , Gilbert , C. , Robinson , T. J. and Graves , J. A. M. ( 2011 ). Evolution from XIST-independent to XIST-controlled X-chromosome inactivation: epigenetic modifications in distantly related mammals . PLoS ONE 6...

...Catherine Patrat; Jean-François Ouimette; Claire Rougeulle ABSTRACT X chromosome inactivation (XCI) is a key developmental process taking place in female mammals to compensate for the imbalance in the dosage of X-chromosomal genes between sexes. It is a formidable example of concerted gene...

... of Biologists Ltd 2017 http://www.biologists.com/user-licence-1-1/ Highlighted article: The genome-wide impact of Xist RNA lacking the A-repeat suggests a significant role for Xist in gene regulation beyond imprinted X inactivation. X chromosome inactivation Xist RNA Trophoblast...

.... References Augui , S. , Nora , E. P. and Heard , E. ( 2011 ). Regulation of X-chromosome inactivation by the X-inactivation centre . Nat. Rev. Genet.   12 , 429 - 442 . 10.1038/nrg2987 Celtikci , B. , Leclerc , D. , Lawrance , A. K. , Deng , L. , Friedman , H. C...

.... Depending on the developmental time window, imprinted or random X chromosome inactivation (XCI) is initiated, and both processes lead to an inactive X chromosome that is clonally inherited. Here, we review new insights into the life cycle of XCI and provide an overview of the mechanisms regulating X...

...Joshua W. Mugford; Della Yee; Terry Magnuson Proper regulation of X-linked gene expression, termed dosage compensation, is required for the normal development of mammalian embryos. Through the process of X chromosome inactivation (XCI), somatic cells of mammalian females inactivate one of their two...

... inactivation De novo DNA methyltransferases Xist It is well known that DNA methylation plays an important role(s) in the regulation of gene expression, maintenance of genomic integrity, parental imprinting and X chromosome inactivation (X-inactivation). It is thought that the methylation pattern...

...-mail: pehrson@vet.upenn.edu ) 10 05 2000 23 03 2000 © 2000 by Company of Biologists 2000 Preimplantation mouse embryo X chromosome inactivation Chromatin Histone X inactivation involves several changes in the structure or properties of the inactive X chromosome...

... trophectoderm derivatives (ectoplacental cone and extraembryonic ectoderm) are severely affected, but the primitive endoderm derivatives (visceral and parietal endoderm) are relatively unaffected. Successful rescue of DsX M embryos by aggregation with tetraploid embryos show that X chromosome inactivation...

... 12 1994 © 1995 by Company of Biologists 1995 cerebral cortex mouse clonal analysis genetic mosaics X chromosome inactivation During early development, neurons in the mammalian cerebral cortex are generated in a proliferative layer known as the ventricular zone ( Boulder...

... and differentiating (XX) ES cells are compatible only with models that do not require Xist RNA to cover the entire inactive X chromosome. 20 09 1994 © 1994 by Company of Biologists 1994 ES cells X chromosome inactivation imprinting allele-specific assays mouse RNA Xist X chromosome...

... of Molecular Biology, Austrian Academy of Sciences, A-5020 Salzburg, Billrothstrasse 11, Austria † Department of Physiology, Colorado State University, Fort Collins, CO 80523, USA 04 08 1992 © 1992 by Company of Biologists 1992 X chromosome inactivation transgenic mice type I...