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Keywords: Wntless
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Journal Articles
Journal: Development
Development (2022) 149 (1): dev199587.
Published: 12 January 2022
... that colonic recovery from colitis-like injury depends on multiple Wnt-producing sources. Wntless Wnt Tagln Acta2 Gpr177 Colitis Wound healing Intestinal stem cell National Institutes of Health R01DK102934 R01DE026936 R01DE015654 R01DK119198 R01AT010243 American Cancer...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (1): dev199505.
Published: 10 January 2022
... mechanisms underlying the epithelial-mesenchymal interaction during alveologenesis are poorly understood. Here, we report that Wnts produced by epithelial cells are crucial for neonatal alveologenesis. Deletion of the Wnt chaperone protein Wntless homolog (Wls) disrupts alveolar formation, resulting...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (22): dev192518.
Published: 19 November 2020
... closure WNT signaling Wntless Sorting nexin Retrograde transport SNX3 Neural tube (NT) closure is the process by which the embryonic precursor of the mammalian brain and spinal cord is formed. It is a highly dynamic morphogenetic process that starts with the specification of the neural...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171496.
Published: 11 February 2019
... during foregut development. Here, we found that ablation of the Wnt chaperone protein Gpr177 (also known as Wntless) in mouse tracheal epithelium causes a significant reduction in the number of basal progenitor cells accompanied by cartilage loss in Shh-Cre;Gpr177 loxp/loxp mutants. Consistent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2147–2162.
Published: 15 June 2015
... the homeostasis of adult tissues. Wnt signaling is a crucial regulator of the stem cell niche, but the mechanism that governs Wnt ligand delivery in this compartment has not been fully investigated. We identified that Wnt secretion is partly dependent on Rab8a-mediated anterograde transport of Gpr177 (wntless...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3589–3594.
Published: 1 September 2013
... Wnts to pulmonary vasculature development. This discrepancy is possibly due to the functional redundancy among different Wnts. Here, we use Shh-Cre to conditionally delete Gpr177 (the mouse ortholog of Drosophila Wntless, Wls), a chaperon protein important for the sorting and secretion of Wnt proteins...
Includes: Supplementary data