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1-20 of 114
Keywords: Wnt signaling
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Journal Articles
In collection:
Stem cells & regeneration
Journal:
Development
Development (2023) 150 (21): dev201890.
Published: 24 October 2023
... embryos. Mechanistically, Csde1 regulates HSPC generation through modulating Wnt/β-catenin signaling activity. We demonstrate that Csde1 binds to ctnnb1 mRNAs (encoding β-catenin, an effector of Wnt signaling) and regulates translation but not stability of ctnnb1 mRNA, which further enhances β-catenin...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal:
Development
Development (2023) 150 (19): dev201671.
Published: 9 October 2023
... ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Commissural axons leave the floor plate and turn rostral by a smooth transition from Robo to Wnt signaling. Cables1 links these pathways by transferring...
Includes: Supplementary data
Journal Articles
Joseph J. Hanly, Ling S. Loh, Anyi Mazo-Vargas, Teomie S. Rivera-Miranda, Luca Livraghi, Amruta Tendolkar, Christopher R. Day, Neringa Liutikaite, Emily A. Earls, Olaf B. W. H. Corning, Natalie D'Souza, José J. Hermina-Perez, Caroline Mehta, Julia A. Ainsworth, Matteo Rossi, Riccardo Papa, W. Owen McMillan, Michael W. Perry, Arnaud Martin
Journal:
Development
Development (2023) 150 (18): dev201868.
Published: 28 September 2023
... canonical Wnt signaling intracellularly in larval wings, and that it activates canonical Wnt signaling as well as Fz/PCP at pupal stages ( Banerjee et al., 2023 ). Our data support the proposed Wnt antagonist role. However, we also found that Fz4 lost its KTxxxW domain in Diptera and Lepidoptera ( Fig. S1...
Includes: Supplementary data
Journal Articles
Renee G. C. Maas, Floor W. van den Dolder, Qianliang Yuan, Jolanda van der Velden, Sean M. Wu, Joost P. G. Sluijter, Jan W. Buikema
Journal:
Development
Development (2023) 150 (15): dev201483.
Published: 10 August 2023
.... , Diecke , S. , Huber , B. , Mordwinkin , N. M. et al. ( 2014 ). Chemically defined generation of human cardiomyocytes . Nat. Methods 11 , 855 - 860 . 10.1038/nmeth.2999 Cadigan , K. M. and Waterman , M. L. ( 2012 ). TCF/LEFs and Wnt signaling in the nucleus...
Journal Articles
Journal:
Development
Development (2023) 150 (15): dev201734.
Published: 4 August 2023
... of canonical Wnt signaling, accumulated. We identified Wnt7b as a factor with increased expression in growth plate cartilage in Smad4 cKO mice. Wnt7b mRNA was expressed in differentiated chondrocytes and suppressed by BMP4 stimulation. Ablation of Wnt7b blunted the increase in bone in adult Smad4 cKO mice...
Includes: Supplementary data
Journal Articles
Nicole A. Repina, Hunter J. Johnson, Xiaoping Bao, Joshua A. Zimmermann, David A. Joy, Shirley Z. Bi, Ravi S. Kane, David V. Schaffer
Journal:
Development
Development (2023) 150 (14): dev201386.
Published: 26 July 2023
... control of cell subpopulations can be used to uncover signaling feedback mechanisms between neighboring cell types. These findings reveal that cell-to-cell variability in Wnt signaling is sufficient to generate tissue-scale patterning and establish a hESC model system for investigating feedback mechanisms...
Includes: Supplementary data
Journal Articles
Pavel Tsaytler, Jinhua Liu, Gaby Blaess, Dennis Schifferl, Jesse V. Veenvliet, Lars Wittler, Bernd Timmermann, Bernhard G. Herrmann, Frederic Koch
Journal:
Development
Development (2023) 150 (10): dev201450.
Published: 22 May 2023
...Pavel Tsaytler; Jinhua Liu; Gaby Blaess; Dennis Schifferl; Jesse V. Veenvliet; Lars Wittler; Bernd Timmermann; Bernhard G. Herrmann; Frederic Koch ABSTRACT Cardiac lineage specification in the mouse is controlled by TGFβ and WNT signaling. From fly to fish, BMP has been identified...
Includes: Supplementary data
Journal Articles
Eva Janečková, Jifan Feng, Tingwei Guo, Xia Han, Aileen Ghobadi, Angelita Araujo-Villalba, Md Shaifur Rahman, Heliya Ziaei, Thach-Vu Ho, Siddhika Pareek, Jasmine Alvarez, Yang Chai
Journal:
Development
Development (2023) 150 (5): dev201189.
Published: 9 March 2023
... canonical Wnt signaling as a key signaling pathway primarily active in cranial neural crest (CNC)-derived mesenchymal cells surrounding soft palatal myogenic cells. Using Osr2-Cre;β-catenin fl/fl mice, we show that Wnt signaling is indispensable for mesenchymal cell proliferation and subsequently...
Includes: Supplementary data
Journal Articles
In collection:
Musculoskeletal system
Ryan P. Liegel, Megan N. Michalski, Sanika Vaidya, Elizabeth Bittermann, Erin Finnerty, Chelsea A. Menke, Cassandra R. Diegel, Zhendong A. Zhong, Bart O. Williams, Rolf W. Stottmann
Journal:
Development
Development (2023) 150 (3): dev201038.
Published: 15 February 2023
... a highly penetrant cleft palate phenotype, shortened limbs compared with wild type and perinatal lethality. Fzd2 D4 craniofacial tissues indicated decreased canonical Wnt signaling. In utero treatment with IIIC3a (a DKK inhibitor) normalized the limb lengths in Fzd2 D4 homozygotes. The in vivo replication...
Includes: Supplementary data
Journal Articles
In collection:
Chromatin & epigenetics
Journal:
Development
Development (2022) 149 (23): dev201124.
Published: 30 November 2022
... (WREs), to activate target gene transcription. Discovering the binding profile of β-catenin is therefore required to unambiguously assign direct targets of WNT signaling. Cleavage under targets and release using nuclease (CUT&RUN) has emerged as prime technique for mapping the binding profile of DNA...
Includes: Supplementary data
Journal Articles
Susanne C. Baess, Ann-Kathrin Burkhart, Sabrina Cappello, Annika Graband, Kristin Seré, Martin Zenke, Catherin Niemann, Sandra Iden
Journal:
Development
Development (2022) 149 (14): dev200154.
Published: 14 July 2022
... deletion showed that melanocytes and immune cells dynamically follow epithelial scale:interscale patterns. Importantly, disrupting Wnt-Lef1 function in keratinocytes caused melanocyte mislocalization to interscale epidermis, implicating canonical Wnt signaling in organizing the pigmentation pattern...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2022) 149 (20): dev200335.
Published: 11 July 2022
... be addressed with in vitro models of human embryos that are derived from embryonic stem cells (hESCs). Our previous work demonstrated that during early stages of hESC differentiation, cells chronicle signaling hierarchy. Only cells that have been exposed (primed) by WNT signaling can respond to subsequent...
Includes: Supplementary data
Journal Articles
In collection:
Musculoskeletal system
Yanshu Wang, Arjun Venkatesh, Jiajia Xu, Mingxin Xu, John Williams, Philip M. Smallwood, Aaron James, Jeremy Nathans
Journal:
Development
Development (2022) 149 (9): dev200340.
Published: 12 May 2022
... and barrier development, also functions as an integral unit in limb development. Wnt signaling Blood-brain barrier Limb development Mouse Howard Hughes Medical Institute Johns Hopkins University The vertebrate limb has been one of the premier systems...
Includes: Supplementary data
Journal Articles
Rebecca Kim, Tingsheng Yu, Jingjing Li, Jan Prochazka, Amnon Sharir, Jeremy B. A. Green, Ophir D. Klein
Journal:
Development
Development (2021) 148 (14): dev199685.
Published: 22 July 2021
... pathway have shown that tooth formation is partly inhibited in loss-of-function mutants, and gain-of-function mutants have perturbed tooth morphology. However, the stage at which Wnt signaling is first important in tooth formation remains unclear. Here, using an Fgf8 -promoter-driven, and therefore early...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (11): dev199408.
Published: 1 June 2021
... that have been conserved over hundreds of millions of years of evolution. These enhancer elements also each contain a conserved perfect consensus-binding site for Tcf7/Lef1, which are the Wnt-regulated transcription factors in cells, revealing how Hox factors and Wnt signaling could intersect to promote...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal:
Development
Development (2021) 148 (9): dev198846.
Published: 29 April 2021
... for reproduction, but how this is achieved is unclear. Here, we show that canonical wingless-type MMTV integration site family (WNT) signaling is pivotal for pre-granulosa cell (pre-GC) activation during PFA. We identified several WNT ligands expressed in pre-GCs that act in an autocrine manner. Inhibition of WNT...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (7): dev191197.
Published: 31 March 2021
...-posterior axis patterning. Wnt signaling Axin Sea urchin Anterior-posterior axis Animal-vegetal axis Endomesoderm During embryonic development in most bilaterally symmetrical animals (Bilateria), the establishment of the anterior-posterior (AP) and dorsal-ventral (DV) axes are two early...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
... by The Company of Biologists Ltd 2021 Summary: To model human birth defects caused by DDX3X mutations, we show that Xenopus DDX3 induces neural crest via the AKT-GSK3β axis, which promotes Wnt signaling and Snai1 stability. DDX3 Neural crest (NC) AKT GSK3β Wnt signaling Xenopus...
Includes: Supplementary data
Journal Articles
Androgen action in cell fate and communication during prostate development at single-cell resolution
Dong-Hoon Lee, Adam W. Olson, Jinhui Wang, Won Kyung Kim, Jiaqi Mi, Hong Zeng, Vien Le, Joseph Aldahl, Alex Hiroto, Xiwei Wu, Zijie Sun
Journal:
Development
Development (2021) 148 (1): dev196048.
Published: 11 January 2021
... of mesenchymal androgen signaling as cellular niches controlling prostate early development. Androgen signaling Prostate development Wnt signaling Sonic hedgehog signaling Mouse models The prostate develops from the endodermal urogenital sinus (UGS) that is derived from the caudal terminus...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
... sustaining the tailbud-derived bipotential neuromesodermal progenitors. Hox genes Brachyury Wnt signaling Neuromesodermal progenitors A hallmark of early embryonic vertebrate development is the progressive formation of the posterior embryonic body from anterior to posterior ( Kimelman...
Includes: Supplementary data
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