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Keywords: Wnt signaling
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Journal Articles
Journal Articles
In collection:
Neural development
Journal: Development
Development (2023) 150 (19): dev201671.
Published: 9 October 2023
... ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Commissural axons leave the floor plate and turn rostral by a smooth transition from Robo to Wnt signaling. Cables1 links these pathways by transferring...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (18): dev201868.
Published: 28 September 2023
... canonical Wnt signaling intracellularly in larval wings, and that it activates canonical Wnt signaling as well as Fz/PCP at pupal stages ( Banerjee et al., 2023 ). Our data support the proposed Wnt antagonist role. However, we also found that Fz4 lost its KTxxxW domain in Diptera and Lepidoptera ( Fig. S1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (15): dev201483.
Published: 10 August 2023
.... , Diecke , S. , Huber , B. , Mordwinkin , N. M. et al. ( 2014 ). Chemically defined generation of human cardiomyocytes . Nat. Methods 11 , 855 - 860 . 10.1038/nmeth.2999 Cadigan , K. M. and Waterman , M. L. ( 2012 ). TCF/LEFs and Wnt signaling in the nucleus...
Journal Articles
Journal: Development
Development (2023) 150 (15): dev201734.
Published: 4 August 2023
... of canonical Wnt signaling, accumulated. We identified Wnt7b as a factor with increased expression in growth plate cartilage in Smad4 cKO mice. Wnt7b mRNA was expressed in differentiated chondrocytes and suppressed by BMP4 stimulation. Ablation of Wnt7b blunted the increase in bone in adult Smad4 cKO mice...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (10): dev201450.
Published: 22 May 2023
...Pavel Tsaytler; Jinhua Liu; Gaby Blaess; Dennis Schifferl; Jesse V. Veenvliet; Lars Wittler; Bernd Timmermann; Bernhard G. Herrmann; Frederic Koch ABSTRACT Cardiac lineage specification in the mouse is controlled by TGFβ and WNT signaling. From fly to fish, BMP has been identified...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (3): dev201038.
Published: 15 February 2023
... a highly penetrant cleft palate phenotype, shortened limbs compared with wild type and perinatal lethality. Fzd2 D4 craniofacial tissues indicated decreased canonical Wnt signaling. In utero treatment with IIIC3a (a DKK inhibitor) normalized the limb lengths in Fzd2 D4 homozygotes. The in vivo replication...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (23): dev201124.
Published: 30 November 2022
... (WREs), to activate target gene transcription. Discovering the binding profile of β-catenin is therefore required to unambiguously assign direct targets of WNT signaling. Cleavage under targets and release using nuclease (CUT&RUN) has emerged as prime technique for mapping the binding profile of DNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (14): dev200154.
Published: 14 July 2022
... deletion showed that melanocytes and immune cells dynamically follow epithelial scale:interscale patterns. Importantly, disrupting Wnt-Lef1 function in keratinocytes caused melanocyte mislocalization to interscale epidermis, implicating canonical Wnt signaling in organizing the pigmentation pattern...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (20): dev200335.
Published: 11 July 2022
... be addressed with in vitro models of human embryos that are derived from embryonic stem cells (hESCs). Our previous work demonstrated that during early stages of hESC differentiation, cells chronicle signaling hierarchy. Only cells that have been exposed (primed) by WNT signaling can respond to subsequent...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (9): dev200340.
Published: 12 May 2022
... and barrier development, also functions as an integral unit in limb development. Wnt signaling Blood-brain barrier Limb development Mouse Howard Hughes Medical Institute Johns Hopkins University The vertebrate limb has been one of the premier systems...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199408.
Published: 1 June 2021
... that have been conserved over hundreds of millions of years of evolution. These enhancer elements also each contain a conserved perfect consensus-binding site for Tcf7/Lef1, which are the Wnt-regulated transcription factors in cells, revealing how Hox factors and Wnt signaling could intersect to promote...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (9): dev198846.
Published: 29 April 2021
... for reproduction, but how this is achieved is unclear. Here, we show that canonical wingless-type MMTV integration site family (WNT) signaling is pivotal for pre-granulosa cell (pre-GC) activation during PFA. We identified several WNT ligands expressed in pre-GCs that act in an autocrine manner. Inhibition of WNT...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (7): dev191197.
Published: 31 March 2021
...-posterior axis patterning. Wnt signaling Axin Sea urchin Anterior-posterior axis Animal-vegetal axis Endomesoderm During embryonic development in most bilaterally symmetrical animals (Bilateria), the establishment of the anterior-posterior (AP) and dorsal-ventral (DV) axes are two early...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev184341.
Published: 19 January 2021
... by The Company of Biologists Ltd 2021 Summary: To model human birth defects caused by DDX3X mutations, we show that Xenopus DDX3 induces neural crest via the AKT-GSK3β axis, which promotes Wnt signaling and Snai1 stability. DDX3 Neural crest (NC) AKT GSK3β Wnt signaling Xenopus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (1): dev196048.
Published: 11 January 2021
... of mesenchymal androgen signaling as cellular niches controlling prostate early development. Androgen signaling Prostate development Wnt signaling Sonic hedgehog signaling Mouse models The prostate develops from the endodermal urogenital sinus (UGS) that is derived from the caudal terminus...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev185298.
Published: 27 November 2020
... sustaining the tailbud-derived bipotential neuromesodermal progenitors. Hox genes Brachyury Wnt signaling Neuromesodermal progenitors A hallmark of early embryonic vertebrate development is the progressive formation of the posterior embryonic body from anterior to posterior ( Kimelman...
Includes: Supplementary data